Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
374 papers
Dual-mechanism vitamin C delivery by polyethylene glycol-23 glyceryl distearate-based niosomes via SVCT2 induction and enhanced transdermal penetration.
Drug delivery · 2026
Polyethylene glycol-23 glyceryl distearate (GDS-23)-a noisome-forming diacylglycerol-polyethylene glycol-based nonionic surfactant-functions as a nanocarrier for drug delivery systems (DDS) and an enhancer of endogenous antioxidant capacity through nuclear factor erythroid 2-related factor 2 (Nrf2) activation. Here, we evaluated the potential of GDS-23 as a multifunctional DDS carrier by… Read on PubMed →
Targeted discovery of anti-skin aging peptides from Camelus bactrianus placenta: Multi-activity screening, network pharmacology, and in vitro validation focusing on MMP-1 inhibition.
Journal of ethnopharmacology · 2026
ETHNOPHARMACOLOGICAL RELEVANCE: Placenta has historically been utilized as a therapeutic agent in traditional medicine, notably as "Ziheche" in traditional Chinese medicine. Similarly, Camelus bactrianus placenta (CBP), known as "Haliyasu" in Mongolian medicine, has been traditionally used to promote health, reduce wrinkles, and alleviate signs of aging. However, its anti-skin aging efficacy and… Read on PubMed →
Ethnopharmacological investigation of Elaeocarpus sylvestris leaf extract in mitigating atopic dermatitis-like lesions via inflammatory signaling modulation.
Journal of ethnopharmacology · 2026
ETHNOPHARMACOLOGICAL RELEVANCE: Historically, Elaeocarpus sylvestris has served as a traditional medicinal agent for inflammatory disorders across East Asia. Recent studies have reported its antioxidant and anti-inflammatory activities, supporting its potential as a natural therapeutic resource for inflammatory skin diseases such as atopic dermatitis (AD). However, its pharmacological relevance to… Read on PubMed →
Kirenol, a diterpene active component from Siegesbeckia orientalis, alleviates atopic dermatitis by suppressing TYK2.
International immunopharmacology · 2026
BACKGROUND: Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease characterized by severe pruritus, skin barrier dysfunction, and underlying immune dysregulation. Kirenol, a major active ingredient and quality control marker from Siegesbeckia orientalis L., has been shown to possess broad pharmacological properties, ranging from anti-arthritic and anti-tumor activities to… Read on PubMed →
Food-derived components as natural skin-whitening strategies: Classification, mechanisms, application forms and prospects.
Food research international (Ottawa, Ont.) · 2026
BACKGROUND: Skin hyperpigmentation has attracted widespread attention. Traditional chemical skin-whitening components pose potential risks, whereas food-derived skin-whitening components are gaining increasing attention owing to their natural food sources and high biocompatibility. SCOPE AND METHODS: This review was conducted by comprehensively searching Google Scholar, Wiley, and Taylor &… Read on PubMed →
Lacticaseibacillus parahuelsenbergensis THGS-36 alleviates acne-like inflammation and lipogenesis in sebocytes via CREB signaling.
Life sciences · 2026
Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit and is associated with Cutibacterium acnes overgrowth, excessive sebum production, and persistent inflammatory responses. This study evaluated the anti-acne potential of the cell-free supernatant (CFS) from Lacticaseibacillus parahuelsenbergensis THGS-36 and investigated its host-modulatory effects in sebocytes with a focus… Read on PubMed →
Mechanistic insights into triclocarban-induced skin barrier disruption via integrating imaging localization, multi-omics, and network toxicology.
Environmental pollution (Barking, Essex : 1987) · 2026
Humans are constantly exposed to the antimicrobial agent triclocarban (TCC) through dermal exposure to a range of household-cleaning and personal-hygiene products, but its potential effects on skin tissue still remain elusive. Here, we employed an integrated multi-omics and network toxicology strategy to explore the cutaneous toxicity of TCC and its underlying mechanisms. Atmospheric pressure… Read on PubMed →
Nonapeptide AOP-P1 ameliorates UVB-induced hyperpigmentation by suppressing melanogenesis via targeting natriuretic peptide receptor 2.
Bioorganic chemistry · 2026
Hyperpigmentation disorders remain challenging to treat because most available agents mainly act on downstream melanogenic enzymes rather than upstream regulatory mechanisms. In this study, we identified AOP-P1, an amphibian skin-derived nonapeptide, as a potent anti-melanogenic peptide with nanomolar activity and no detectable cytotoxicity. By integrating in vitro and in vivo functional assays… Read on PubMed →
Exploring the photoprotective and antiaging potential of Padina pavonica loaded Hyatocosomes: In-vitro evaluation and biological studies.
Bioorganic chemistry · 2026
The increasing demand for effective natural ingredients has transformed the skincare market, driving interest in physiologically active compounds with proven biological effects. Padina pavonica (PA), a brown alga, is recognized for its antioxidant, anti-aging, and UV-protective properties. This study aimed to enhance the pharmacological benefits of PA via nanoencapsulation in hyatocosomes (HT), a… Read on PubMed →
Compound Platycladus orientalis tincture promotes hair regrowth and is associated with hair-cycle progression and Wnt/β-catenin-related signaling.
Journal of ethnopharmacology · 2026
ETHNOPHARMACOLOGICAL RELEVANCE: Alopecia is traditionally managed in Chinese medicine using topical botanical preparations aimed at restoring hair-cycle dynamics and improving the follicular microenvironment. Compound Platycladus orientalis tincture (CPT), an ethanol-based polyherbal formulation consisting of Platycladi Cacumen, Szechwan Chinaberry Fruit, and Herba Speranskiae Tuberculatae, has… Read on PubMed →
Traditional Chinese medicine in acne treatment: From classical formulas to bioactive phytoconstituents and mechanisms.
Journal of ethnopharmacology · 2026
ETHNOPHARMACOLOGICAL RELEVANCE: Acne vulgaris is a multifactorial inflammatory skin condition that affects over 80% of adolescents worldwide. Conventional monotherapy often fails to address sebaceous hyperplasia, Cutibacterium acnes dysbiosis and epidermal barrier dysfunction concurrently. Traditional Chinese herbal medicine (CHM) has long been used to treat acne patterns such as 'damp-heat' or… Read on PubMed →
Assessment and treatment of adolescent hair loss.
Current opinion in pediatrics · 2026
PURPOSE OF REVIEW: Hair loss in adolescents carries significant psychosocial impact, and it is often underrecognized and managed without adolescent-specific approaches. This review describes recent advances in diagnostics, pathophysiology, and therapies to improve diagnosis and management of adolescent alopecia. RECENT FINDINGS: Trichoscopy and ultraviolet-enhanced follicular dermoscopy improve… Read on PubMed →
Emerging topical nonsteroidal therapies in pediatric dermatology: atopic dermatitis, psoriasis, alopecia areata, vitiligo, and seborrheic dermatitis.
Current opinion in pediatrics · 2026
PURPOSE OF REVIEW: To review the current literature for updates on pediatric nonsteroidal topical therapies (NSTT) for the treatment of atopic dermatitis (AD), psoriasis, alopecia areata (AA), vitiligo, and seborrheic dermatitis (SD). RECENT FINDINGS: The FDA approved difamilast and expanded the approved age ranges for roflumilast, tapinarof, and ruxolitinib to treat AD. Recent studies also show… Read on PubMed →
Synergistic effects of glucocorticoid and N2-gas cold atmospheric plasma in a mouse model of atopic dermatitis.
International immunopharmacology · 2026
Atopic dermatitis (AD) is characterized by impaired skin barrier function, chronic inflammation, and increased susceptibility to infection. Although topical glucocorticoids are effective, long-term use is limited by adverse effects, highlighting the need for steroid-sparing strategies. This study investigated the immunomodulatory and therapeutic effects of nitrogen-based cold atmospheric plasma… Read on PubMed →
Hormonal acne therapies in pediatrics.
Current opinion in pediatrics · 2026
BACKGROUND: Acne vulgaris is one of the most common inflammatory skin conditions in adolescents, affecting up to 85% of individuals aged 12-24 years. Beyond its physical manifestations, acne can significantly impact self-esteem, quality of life, and psychological well-being. DISCUSSION: Acne has a multifactorial pathogenesis involving follicular hyperkeratinization, increased sebum production… Read on PubMed →
Amentoflavone mitigates UVB-induced epidermal photoaging by antagonizing PAR2-driven PI3K/Akt/FoxO6 oxidative-stress signaling.
Free radical biology & medicine · 2026
Escalating surface ultraviolet-B (UVB) radiation accelerates skin photoaging and underscores the need for safe, plant-derived photoprotectants. Amentoflavone (AF), the principal biflavonoid of the resurrection plant Selaginella tamariscina, has recognized anti-photoaging activity, yet its epidermal mechanism remains undefined. This study utilized animal and cellular models to investigate the… Read on PubMed →
Protective effect of (-)-Loliode isolated from Sargassum horneri against particulate matter-induced skin damage via inhibiting pro-inflammatory cytokines and matrix metalloproteinases expression.
Chemico-biological interactions · 2026
Particulate matter (PM) is a pervasive carcinogen that can exacerbates skin inflammation, oxidative damage with extracellular matrix (ECM) degradation, thereby compromising skin barrier integrity and promoting premature aging. In this study, the protective potential and mechanistic basis of (-)-Loliode separated from Sargassum horneri, used for PM-induced skin injury is investigated. In vitro… Read on PubMed →
Epalrestat repurposing for psoriasis: Targeting AKR1B10 to modulate the metabolic-immune axis via restoring retinol metabolism and suppressing IL-17 signaling.
International immunopharmacology · 2026
BACKGROUND: Psoriasis is a chronic inflammatory disease often accompanied by metabolic syndrome. The function of AKR1B10 in the "metabolism-immune" interplay remains unclear. This study aimed to identify the role of AKR1B10 in pathogenesis and evaluate its inhibitor, Epalrestat, for psoriasis treatment via drug repurposing. METHODS: Integrating GEO transcriptomic data, we screened for key… Read on PubMed →
Hyaluronic acid-based microneedles: materials design, fabrication strategies, challenges, and solutions for biomedical applications.
International journal of pharmaceutics · 2026
Hyaluronic acid (HA)-based microneedles have emerged as highly promising minimally invasive platforms for transdermal and transmucosal drug delivery, overcoming the limitations of conventional oral, topical, and injectable therapies. Owing to its excellent biocompatibility, biodegradability, hydrophilicity, non-immunogenicity, and intrinsic bioactivity, HA functions not only as a structural… Read on PubMed →
Microneedle array platforms for drug delivery and biomarker sensing: From skin mechanics guided design to scalable manufacture for clinical utility.
Journal of controlled release : official journal of the Controlled Release Society · 2026
Microneedle (MN) devices provide a platform for development of products that can facilitate intra-and trans-dermal delivery and sampling of active pharmaceutical ingredient (APIs) and biomarkers that would otherwise be restricted by the skin barrier. Despite significant progress in the development of laboratory-based prototypes, no Microneedle Array Patch (MAP) drug delivery products have been… Read on PubMed →