Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
47 papers under Acne
Lacticaseibacillus parahuelsenbergensis THGS-36 alleviates acne-like inflammation and lipogenesis in sebocytes via CREB signaling.
Life sciences · 2026
Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit and is associated with Cutibacterium acnes overgrowth, excessive sebum production, and persistent inflammatory responses. This study evaluated the anti-acne potential of the cell-free supernatant (CFS) from Lacticaseibacillus parahuelsenbergensis THGS-36 and investigated its host-modulatory effects in sebocytes with a focus… Read on PubMed →
Traditional Chinese medicine in acne treatment: From classical formulas to bioactive phytoconstituents and mechanisms.
Journal of ethnopharmacology · 2026
ETHNOPHARMACOLOGICAL RELEVANCE: Acne vulgaris is a multifactorial inflammatory skin condition that affects over 80% of adolescents worldwide. Conventional monotherapy often fails to address sebaceous hyperplasia, Cutibacterium acnes dysbiosis and epidermal barrier dysfunction concurrently. Traditional Chinese herbal medicine (CHM) has long been used to treat acne patterns such as 'damp-heat' or… Read on PubMed →
Hormonal acne therapies in pediatrics.
Current opinion in pediatrics · 2026
BACKGROUND: Acne vulgaris is one of the most common inflammatory skin conditions in adolescents, affecting up to 85% of individuals aged 12-24 years. Beyond its physical manifestations, acne can significantly impact self-esteem, quality of life, and psychological well-being. DISCUSSION: Acne has a multifactorial pathogenesis involving follicular hyperkeratinization, increased sebum production… Read on PubMed →
Comparing a Red and Blue Light-Emitting Diode Light Device With an Existing Blue Light Device for At-Home Treatment of Inflammatory Acne: An Open-Label Randomized-Controlled Trial.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2026
BACKGROUND: Red and blue light have beneficial, complementary effects on acne. OBJECTIVE: To evaluate the efficacy and safety of at-home treatment of mild-to-moderate inflammatory acne with an investigational combination 660-nm red/415-nm blue light-emitting diode device (RBL) compared with a commercially available 415-nm blue light-emitting diode device (BL). MATERIALS AND METHODS: This was an… Read on PubMed →
Comparing fractional CO₂ laser and needling-based modalities in facial acne scar treatment: a comprehensive systematic review and meta-analysis.
Lasers in medical science · 2026
Facial acne scarring is a widely prevalent dermatological disease manifested as a permanent aftereffect of acne vulgaris. While fractional CO₂ laser and needling procedures are essential to treating atrophic acne scars, comparative and safety data remains limited. This systematic review and meta-analysis directly compares their efficacy and safety. According to PRISMA guidelines, PubMed, Cochrane… Read on PubMed →
Exploring the Lived Experience of Acne in the United States and the United Kingdom: Social Media Analysis.
JMIR dermatology · 2026
BACKGROUND: Acne is a chronic skin condition that primarily affects adolescents and young adults but can persist into adulthood. It can have repercussions on physical and mental health, self-esteem, and body image. The increasing use of social media for health information and peer support offers an opportunity to explore real-life experiences with acne. OBJECTIVE: This study aims to analyze… Read on PubMed →
CBD-Containing Hemp Extracts and Isolated CBD for Acne: A Systematic Review of Anti-Inflammatory Mechanisms, Clinical Signals and Sustainability.
Molecules (Basel, Switzerland) · 2026
Industrial hemp (Cannabis sativa L.) has emerged as a sustainable source of bioactive compounds, with increasing interest in cosmeceutical applications for acne management. This systematic review synthesises evidence on cannabinoid-containing hemp extracts, particularly cannabidiol (CBD), with emphasis on anti-inflammatory and sebostatic mechanisms, alongside formulation considerations and… Read on PubMed →
Oral probiotics and topical secretome to enhance clinical outcomes and microbiome restoration in acne vulgaris: a double-blind, randomised controlled trial protocol.
BMJ open · 2026
BACKGROUND: Acne vulgaris is a chronic inflammatory condition primarily caused by Cutibacterium acnes, which disrupts skin homeostasis, thereby triggering immune responses and sebum metabolism. Dysbiosis is an imbalance in the skin and gut microbiota identified as a significant factor contributing to acne progression. Standard therapy often relies on antibiotics, but the long-term use has… Read on PubMed →
Treating Acne Vulgaris and Scarring With Botulinum Toxin: A Systematic Review.
Journal of drugs in dermatology : JDD · 2026
BACKGROUND: Many treatments have been proposed for the treatment of acne vulgaris and acne scarring; however, few data exist regarding the efficacy of botulinum toxin A as a treatment option. OBJECTIVE: To compile all available data on the efficacy and safety of botulinum toxin A as a treatment for acne vulgaris and acne scarring. METHODS: A systematic review of PubMed/MEDLINE, Excerpta Medica… Read on PubMed →
Efficacy and Safety of Clascoterone Cream 1% and Clindamycin 1.2%/Benzoyl Peroxide 5% Gel Treatment in Patients With Acne.
Journal of drugs in dermatology : JDD · 2026
BACKGROUND: Clascoterone cream 1% is a topical androgen receptor inhibitor approved to treat acne vulgaris in patients ≥12 years of age. The American Academy of Dermatology recommends combining topical therapies that target different mechanisms of acne pathogenesis as first-line treatment for acne. This 16-week, open-label pilot study evaluated the efficacy and safety of clascoterone cream 1%… Read on PubMed →
Randomized Controlled Study of Bacteriophages in Acne Reveals Efficacy and Novel Mechanism for Promoting Long-Term Skin Health.
Journal of drugs in dermatology : JDD · 2026
BACKGROUND: Acne is the most prevalent skin disease globally, with a significant burden and limited therapeutic innovation. Although it has a multifactorial etiology, Cutibacterium acnes (C acnes) overgrowth is a key factor in driving inflammation in acne. Bacteriophages are a novel mechanism that can specifically target C acnes and are found in greater abundance on healthy skin compared to… Read on PubMed →
Efficacy and safety of recombinant human epidermal growth factor combined with fractional carbon dioxide laser for facial atrophic acne scars: a systematic review and meta-analysis of randomized trials.
Lasers in medical science · 2026
BACKGROUND: The combination of recombinant human epidermal growth factor (rhEGF) and fractional carbon dioxide (CO2) laser therapy is increasingly used in the treatment of facial atrophic acne scars. OBJECTIVE: This study aimed to systematically assess the efficacy and safety of rhEGF combined with fractional CO2 laser therapy for managing facial atrophic acne scars. METHODS: PubMed, Embase, the… Read on PubMed →
A co-amorphous salt of ursodeoxycholic acid and matrine incorporated into dissolving microneedles for combined antibacterial and anti-inflammatory treatment of acne vulgaris.
International journal of pharmaceutics · 2026
Acne vulgaris is characterized by microbial dysbiosis and excessive inflammatory activation, whereas current topical therapies are often limited by poor skin penetration and increasing antibiotic resistance. Ursodeoxycholic acid (UDCA) has anti-inflammatory potential but suffers from low aqueous solubility and limited cutaneous permeability. In this study, a co-amorphous salt of UDCA and matrine… Read on PubMed →
Polysaccharide-Based Soluble Microneedle Transdermal Delivery of Curcumin Synergized with Photothermal Therapy for Acne Treatment.
ACS applied materials & interfaces · 2026
Acne is a chronic inflammatory skin disease driven primarily by Propionibacterium acnes (P. acnes) colonization in hair follicles, which can progress from mild to severe forms and result in permanent scarring if left untreated. To resolve this problem, this study developed a polysaccharide-based light-heat-mediated soluble microneedle system for the transdermal delivery of antiacne agents… Read on PubMed →
Comparison of the Burden of Acne Vulgaris in China vs Globally: Insights from the Global Burden of Disease Study (2021) and Projections to 2050.
Acta dermato-venereologica · 2026
Acne vulgaris (AV) poses a significant health challenge in China, adversely affecting patients' quality of life and mental health. Updated evidence on acne burden in China integrating temporal trends, China-global comparisons, change-point patterns, and future projections remains limited. This study aimed to provide an updated assessment of AVacne vulgaris burden in China, including temporal… Read on PubMed →
Oral myo-inositol plus D-chiro-inositol (3.6:1) reduces insulin resistance pathway biomarkers in acne-involved skin among subjects with metabolic comorbidities: A gene expression study.
Neuro endocrinology letters · 2026
BACKGROUND: Hyperinsulinemia and insulin resistance promote acne pathogenesis through reduced Forkhead box protein O1 (FOXO1) signaling and increased mechanistic target of rapamycin (MTOR) and insulin-like growth factor-1 (IGF1) activity. While oral myo-inositol (MI) and D-chiro-inositol (DCI) supplementation may improve insulin sensitivity, evidence regarding direct pathway modulation in… Read on PubMed →
Efficacy of oral azithromycin versus oral doxycycline in treating moderate acne vulgaris and their effects on patients' quality of life.
Scientific reports · 2026
This study aimed to compare the efficacy of oral azithromycin with oral doxycycline in moderate acne vulgaris and to assess the corresponding changes in patient-reported quality-of-life. In this open label, randomised controlled trial conducted at a university student clinic, Muscat, Oman, 163 patients with moderate and severe acne vulgaris were assigned equally to receive either oral azithromycin… Read on PubMed →
Psychosocial impact of acne among medical, Speech and Hearing Sciences, and Occupational Therapy undergraduates at a Sri Lankan University.
BMC psychology · 2026
BACKGROUND: Acne vulgaris is associated with substantial psychosocial effects, including impaired socioemotional well-being among young adults. This study aimed to determine the prevalence of acne and to examine the relationships and predictive effects of acne-related quality of life on psychological distress and self-esteem, in addition to exploring gender differences among medical and allied… Read on PubMed →
Fact-Checking Large Language Model Responses to a Health Care Prompt: Comparative Study.
JMIR formative research · 2026
BACKGROUND: Large language models use machine learning to produce natural language. These models have a range of potential applications in health care, such as patient education and diagnosis. However, evaluations of large language models in health care are still scarce. OBJECTIVE: This study aimed to (1) evaluate the accuracy and efficiency of automated fact-checking by 2 large language models… Read on PubMed →
Chemical Characteristics and Antimicrobial Activity of Arctostaphylos uva-ursi (L.) Spreng. Extracts Against Skin-Associated Bacteria.
Molecules (Basel, Switzerland) · 2026
The interest in the use of phytochemicals and herbal medicines for the treatment of acne vulgaris has grown steadily over recent decades. The research on the secondary metabolites and biological properties of bearberry (Arctostaphylos uva-ursi (L.) Spreng.) has been intensified in recent years, but the range of bacterial strains tested, many of which are highly relevant to human health, remains… Read on PubMed →