Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
12 papers under Niacinamide
Enhanced biodistribution and efficacy of nicomenthyl encapsulated in emulsions stabilized by methacrylated hyaluronic acid for the prevention and treatment of skin photoaging.
Carbohydrate polymers · 2026
Nicomenthyl (NM), prodrug of niacinamide (vitamin B3), is widely used in skin applications for their biological benefits, but remain mainly in the stratum corneum (SC). Bioactive methacrylate-functionalized hyaluronic acid (HA-MA) (44.5 KDa; degree of substitution: 80-100%), used to stabilize Oil-in-Water emulsions (EM) as new application for polysaccharide, represent an effective strategy to… Read on PubMed →
Efficacy of hydrocolloid dressing for hand-foot skin reaction: J-SUPPORT 1701 APRON trial.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
PURPOSE: Since hand-foot skin reaction (HFSR) is a dose-limiting toxicity associated with certain multikinase inhibitors, prophylactic measures to manage this adverse effect require improvement. This study aimed to evaluate the efficacy of depressurization using hydrocolloid dressing by comparing the effects of adding hydrocolloid dressing to standard prophylactic moisturizing versus moisturizing… Read on PubMed →
Skin Cancer Prevention and Antiaging: Role of Nicotinamide.
International journal of molecular sciences · 2026
Nicotinamide (NAM), the amide form of vitamin B3, has gained increasing attention in dermatology due to its potential role in both skin aging and non-melanoma skin cancer (NMSC) prevention. This review summarizes the biological rationale and current clinical evidence supporting the use of NAM and other NAD+ precursors in photoaging and cutaneous carcinogenesis. Chronic ultraviolet exposure induces… Read on PubMed →
Bi-directional regulation between NAD/NAMPT and IFN-γ/PD-L1 axes via BRD4/IRF1 and mitochondrial respiration in metastatic cutaneous melanoma.
Journal of experimental & clinical cancer research : CR · 2026
BACKGROUND: Metastatic cutaneous melanoma (MCM) is primarily treated with BRAF/MEK inhibitors and immune checkpoint inhibitors (ICIs), but the long-term efficacy of these therapies is often limited by acquired resistance. Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in NAD biosynthesis, is frequently upregulated in MCM, supporting metabolic rewiring and targeted therapy… Read on PubMed →
The study of transdermal delivery mechanism of liposomes using stratum corneum lipid membrane model.
Colloids and surfaces. B, Biointerfaces · 2026
A reliable assessment of skin permeation is essential for the rational design of transdermal formulations which effectively deliver active ingredients. In particular, a skin screening platform capable of evaluating skin permeability and elucidating the penetration mechanisms of skin penetration enhancers (SPEs), such as liposomes, is critical for advancing transdermal delivery systems. Here, we… Read on PubMed →
Changes in ultraviolet a radiation-induced thymidine dimers and erythema after oral nicotinamide or polypodium leucotomos extract in healthy volunteers: a randomized intraindividual trial.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
BACKGROUND: Nicotinamide (NAM) and Polypodium leucotomos extract (PL) have demonstrated photoprotective effects, but their role in preventing UVA-induced DNA damage in humans remains unclear. OBJECTIVE: To evaluate the effects of oral NAM and PL on UVA-induced erythema and thymidine dimer (TT-dimer) formation. METHODS: In this intraindividual trial, 50 healthy volunteers (phototypes I-III) were… Read on PubMed →
Efficacy and Safety of a Topical Nicotinamide Adenine Dinucleotide Skinbooster for the Treatment of Melasma.
Aesthetic plastic surgery · 2026
BACKGROUND: Melasma remains a therapeutically challenging hyperpigmentation disorder due to its high recurrence rate and the limitations of existing topical therapies. Nicotinamide adenine dinucleotide (NAD+) is a fundamental coenzyme critical for mitochondrial bioenergetics, DNA repair, and NAD+-dependent sirtuin-mediated gene regulation. Its systemic decline is implicated in cellular ageing and… Read on PubMed →
An alginate-based 3D cell culture model as a useful tool for melanoma drug testing.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026
Melanoma, the most lethal form of skin cancer, presents significant treatment challenges because of its early metastasis and dormancy. Despite substantial advancements in melanoma research, particularly in understanding molecular alterations during early tumor development and melanoma progression, a comprehensive understanding remains elusive. In tumor therapy, novel therapeutic modalities, such… Read on PubMed →
Safety and efficacy of individualised exercise and NAD+ precursor supplementation in patients with Friedreich's ataxia in the USA: a single-centre, 2 × 2 factorial, randomised controlled trial.
The Lancet. Neurology · 2026
BACKGROUND: Friedreich's ataxia is a rare, chronic, progressive, neurodegenerative condition affecting multiple organ systems, including neurological, musculoskeletal, cardiac, and endocrine systems, and is marked by low cardiopulmonary fitness. We tested the effect of exercise and NAD+ precursor supplementation with nicotinamide riboside, which have each shown benefits in animal and early… Read on PubMed →
Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial.
Journal of cosmetic dermatology · 2026
BACKGROUND: Xerosis cutis is characterized by impaired epidermal barrier function, increased transepidermal water loss (TEWL), reduced hydration, and symptoms such as pruritus. AIMS: To evaluate the efficacy, tolerability, and subjective perception of a topical formulation containing panthenol, niacinamide, and dipotassium glycyrrhizate in improving skin hydration and barrier function in subjects… Read on PubMed →
Multitargeted Modulation of Skin Dullness by HNHT Formulation: Synergistic Inhibition of Melanogenesis, Glycation, and Lipofuscin Deposition.
Journal of cosmetic dermatology · 2026
BACKGROUND: Skin dullness, characterized by pigmentation disorders and yellowing, is a major cosmetic concern in Asian populations. Lipofuscin exhibits ultraviolet (UV)/visible light spectral absorption, reduces skin reflectance, and contributes to dullness, whereas existing therapies targeting melanogenesis and glycation lack comprehensive efficacy. This study aimed to evaluate the multimodal… Read on PubMed →
Stability and dermal safety of Ti3C2Tx MXenes for potential skin-interfaced biosensor applications.
Environment international · 2026
Ti3C2Tx MXene is a two-dimensional material with exceptional electrical conductivity, rendering them promising candidates as ink for printable skin biosensors. However, their susceptibility to oxidation under biologically relevant conditions and the consequences of oxidation on material properties remain unclear, posing challenges for practical applications. The skin is the barrier to the external… Read on PubMed →