Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
57 papers under Sunscreen
Exploring the photoprotective and antiaging potential of Padina pavonica loaded Hyatocosomes: In-vitro evaluation and biological studies.
Bioorganic chemistry · 2026
The increasing demand for effective natural ingredients has transformed the skincare market, driving interest in physiologically active compounds with proven biological effects. Padina pavonica (PA), a brown alga, is recognized for its antioxidant, anti-aging, and UV-protective properties. This study aimed to enhance the pharmacological benefits of PA via nanoencapsulation in hyatocosomes (HT), a… Read on PubMed →
Amentoflavone mitigates UVB-induced epidermal photoaging by antagonizing PAR2-driven PI3K/Akt/FoxO6 oxidative-stress signaling.
Free radical biology & medicine · 2026
Escalating surface ultraviolet-B (UVB) radiation accelerates skin photoaging and underscores the need for safe, plant-derived photoprotectants. Amentoflavone (AF), the principal biflavonoid of the resurrection plant Selaginella tamariscina, has recognized anti-photoaging activity, yet its epidermal mechanism remains undefined. This study utilized animal and cellular models to investigate the… Read on PubMed →
The Rise in Homemade Sunscreen Trends and Future Impacts on Skin Cancer Risk: Systematic Review.
JMIR dermatology · 2026
BACKGROUND: The trend of homemade sunscreen recipes has rapidly gained popularity over the last decade, being largely fueled by social media influencers, natural health blogs, and the growing mistrust of large health organizations like the US Food and Drug Administration (FDA). Consumers are increasingly drawn to products labeled "natural," "organic," "vegan," and "cruelty-free," often conflating… Read on PubMed →
Sakuranin attenuates UVB-induced skin damage by preserving mitochondria-ER coupling and restoring redox-organelle homeostasis.
International immunopharmacology · 2026
Ultraviolet B (UVB) irradiation elicits complex intracellular stress responses that drive keratinocyte injury and skin photoaging through coordinated disruption of redox homeostasis, mitochondrial dynamics, and endoplasmic reticulum (ER) stress signaling at mitochondria-ER contact sites. This study investigated whether sakuranin (SKR), a naturally occurring flavanone glycoside, exerts… Read on PubMed →
Ultraviolet arrows signal immediate, ever-present danger: development and evaluation of a skin cancer prevention campaign to improve young adults' sun protection in Australia.
Public health research & practice · 2026
OBJECTIVES AND IMPORTANCE OF STUDY: Melanoma of the skin is highly preventable, with >97% of cases in Australia/New Zealand caused by overexposure to ultraviolet radiation. Young adults aged 18-24 years are at greater risk of overexposure than older adults due to lower use of some forms of sun protection, spending more time in the sun, and being more likely to attempt tanning and experience… Read on PubMed →
Preclinical development of a 3D-printed hollow microneedle platform for intradermal delivery of antioxidant-loaded nanocarriers.
International journal of pharmaceutics · 2026
The poor penetration of topical antioxidants underscores the need for advanced intradermal delivery platforms that overcome stratum corneum limitations while protecting labile compounds. Despite their efficacy, in-clinic treatments (microneedling, laser, injections) require frequent administration and entail high costs. Hollow microneedles (HMNs) provide a minimally invasive, precise, and… Read on PubMed →
High-Level Secretory Expression of Recombinant Type XVII Human-like Collagen in Komagataella phaffii.
International journal of molecular sciences · 2026
Type XVII collagen (COL17) is crucial for skin integrity but difficult to produce. To achieve high-level secretory expression, a human COL17 segment was designed and cloned into the pPIC9K vector with six different α-mating factor signal peptides and integrated into Komagataella phaffii GS115. Fed-batch fermentation in a 5 L bioreactor yielded 4.7 g/L of recombinant COL17. Functional assays showed… Read on PubMed →
Usnic Acid and Its Topical Use-A Concise Review.
Molecules (Basel, Switzerland) · 2026
Usnic acid (UA), a prominent lichen secondary metabolite, exhibits a unique dual therapeutic profile in dermatology, though its clinical translation is limited by systemic hepatotoxicity and poor solubility. This review comprehensively evaluates the topical efficacy, molecular mechanisms, and advanced formulation strategies of UA enantiomers and UA-rich extracts. A literature search across PubMed… Read on PubMed →
Microscopic Fungi as Sources of Natural UV-Protective Compounds.
Current microbiology · 2026
The search for sustainable and biocompatible alternatives to synthetic sunscreens has intensified due to concerns about the safety and environmental persistence of conventional UV filters. Although algae and bacteria have been extensively explored as sources of photoprotective metabolites, microscopic fungi remain comparatively neglected despite remarkable metabolic diversity and ecological… Read on PubMed →
Lawsone modulates oxidative stress, apoptosis, and enhances growth factor expression in human dermal fibroblasts under hyperglycemic conditions.
Molecular biology reports · 2026
INTRODUCTION: Delayed wound healing is a serious issue in diabetes, which is driven by metabolic and non-metabolic factors. Dysfunction and decreased lifespan of fibroblast cells play a key role in this condition. Lawsone (2-hydroxy-1,4-naphthoquinone), the main active component of Lawsonia inermis, is well known for its anticancer and regenerative effects, although these effects vary depending on… Read on PubMed →
Metal-Polyphenol Network Confined Synthesis of Nanozymes with Programmable Oxygen Vacancies for UVB Photodamage Therapy.
Nano letters · 2026
Conventional sunscreens block ultraviolet B (UVB) but fail to scavenge accumulated reactive oxygen species (ROS), causing severe photodamage. Herein, we develop a room-temperature, aqueous coordination strategy that assembles metal-polyphenol networks (MPNs) to confine in situ nucleation and growth of metal oxide nanozymes. Utilizing tannic acid coordinated ceria (CeO2-TA) as a model system, we… Read on PubMed →
Development and characterization of dibenzalacetone-loaded oleogels as a potential photoprotective agents for sunscreen formulations.
Scientific reports · 2026
Prolonged exposure to ultraviolet radiation induces erythema, accelerates photoaging, and increases the risk of skin cancer. Sunscreens are the primary strategy for preventing UV-induced skin damage; however, the effective topical delivery of photoprotective agents is often limited by formulation challenges. Dibenzalacetone (DBA), a chalcone derivative with broad UVA and UVB absorption, exhibits… Read on PubMed →
Photoprotective Effects of Dendrobium officinale Protein Hydrolysate Fractions Against UVB-Induced Photoaging Associated with Modulation of MAPK/NF-κB and TGF-β/Smad Signaling.
Molecules (Basel, Switzerland) · 2026
Dendrobium officinale has attracted increasing attention as a functional food because of its diverse biological activities; however, the photoprotective potential of its protein-derived peptides remains poorly understood. In this study, D. officinale protein hydrolysates were fractionated by ultrafiltration according to molecular weight, and their protective effects against ultraviolet B… Read on PubMed →
Skin health in oncology: evidence-based skin care for cancer patients.
The oncologist · 2026
BACKGROUND: Cancer and its treatments frequently compromise skin integrity, leading to xerosis, pruritus, dermatitis, radiation-induced skin damage, and secondary infections. These cutaneous adverse events (cAEs) are not merely superficial; they profoundly impact patient quality of life (QoL), contributing to physical discomfort, psychosocial distress, and poorer treatment adherence. Even mild… Read on PubMed →
"Dual-Bottle, Dual-Mode" Intelligent Delivery System for Scenario-Specific Delivery of Astaxanthin and Skin Photoaging Protection.
ACS applied materials & interfaces · 2026
Astaxanthin (AX) faces several challenges in topical skin applications, including poor water solubility, low photostability, undesirable staining, and uncontrolled release. To address these, this study developed a "dual-bottle, dual-mode" intelligent delivery system. First, sulfobutylether-β-cyclodextrin (SBE-β-CD) inclusion technology was used to prepare an AX@SBE-β-CD inclusion complex, greatly… Read on PubMed →
A Randomized Controlled Trial Analyzing the Likeability, Usability, and In-Use Efficacy of Mineral Sunscreens Across Diverse Skin Tones.
Journal of drugs in dermatology : JDD · 2026
BACKGROUND: Mineral sunscreens are increasingly favorable among consumers. However, mineral sunscreens typically cause a white cast that can impact consumer selection and application. OBJECTIVE: This study measured the whitening effect of mineral sunscreens across diverse skin tones and evaluated its relationship with consumer perception, application behavior, and the product's efficacy in terms… Read on PubMed →
Prevalence and Context of Sunburn Among U.S. Adults - United States, 2024.
MMWR. Morbidity and mortality weekly report · 2026
Sunburn is an important risk factor for skin cancer. Understanding sunburn prevalence and the contexts in which sunburn commonly occurs might help guide the development and implementation of sun safety interventions. Data from the 2024 National Health Interview Survey sample adult questionnaire were analyzed to describe the prevalence of one or more and four or more sunburns among U.S. adults… Read on PubMed →
Protecting Skin from UV Exposure with Dietary Polyphenols: Comparison of Phenolic Metabolites in an Ex Vivo Skin Explant Model.
Journal of agricultural and food chemistry · 2026
Dietary berry consumption generates circulating gut-derived phenolic metabolites linked to systemic health benefits, yet their roles in enhancing skin resilience against environmental stressors are unclear. This study evaluated the protective effects of wild blueberry polyphenolic metabolites on ex vivo human skin biopsies exposed to ultraviolet irradiation. The metabolites were derived from… Read on PubMed →
Skin Staphylococcus species differentially modulate keratinocyte cytokine secretion in response to UVB.
Applied and environmental microbiology · 2026
Skin acts as the body's first line of defense against environmental insults including ultraviolet radiation (UVR) from sunlight and engages in a dynamic dialog with the resident skin microbiota, increasingly recognized for its role in shaping and educating the immune responses of the skin in both health and disease. However, how or indeed if the resident skin microbiota mediates inflammatory… Read on PubMed →
3D-Printed lesion-conformal light-guiding patches for precise and personalized psoriasis phototherapy.
Biomaterials science · 2026
Psoriasis is a chronic inflammatory skin disorder marked by epidermal hyperplasia and hyperkeratosis, with lesions presenting highly irregular geometric patterns and a discrete distribution. Traditional phototherapy, lacking spatial selectivity, often causes radiation damage to surrounding healthy tissue, thereby limiting treatment dosage and frequency. In this study, we developed… Read on PubMed →