Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
49 papers under Retinoids
Epalrestat repurposing for psoriasis: Targeting AKR1B10 to modulate the metabolic-immune axis via restoring retinol metabolism and suppressing IL-17 signaling.
International immunopharmacology · 2026
BACKGROUND: Psoriasis is a chronic inflammatory disease often accompanied by metabolic syndrome. The function of AKR1B10 in the "metabolism-immune" interplay remains unclear. This study aimed to identify the role of AKR1B10 in pathogenesis and evaluate its inhibitor, Epalrestat, for psoriasis treatment via drug repurposing. METHODS: Integrating GEO transcriptomic data, we screened for key… Read on PubMed →
Pediatric Genital Endemic Kaposi Sarcoma with Partial Response to Adapalene.
The American journal of tropical medicine and hygiene · 2026
Kaposi sarcoma (KS) is a human herpesvirus 8 (HHV-8)-associated vascular neoplasm that most commonly affects immunocompromised individuals. Endemic KS occurs in sub-Saharan Africa but rarely involves the anogenital region in pediatric patients. We report a case of a 12-year-old immunocompetent Ghanaian girl presenting with rapidly progressive nodular and fungating masses involving the trunk and… Read on PubMed →
Chemoprevention of keratinocyte carcinomas and actinic keratoses in adults who were immunocompetent: a systematic review.
Clinical and experimental dermatology · 2026
BACKGROUND: Keratinocyte carcinomas (KCs), comprising basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are the most common skin cancers worldwide. Actinic keratoses (AKs) are precursors to SCCs and markers of cumulative ultraviolet damage. Chemoprevention has been explored in cohorts who are high risk or immunosuppressed, however, their value in adults who are immunocompetent remains… Read on PubMed →
Pachydermoperiostosis (Touraine-Solente-Gole syndrome): A case report and literature review.
Medicine · 2026
RATIONALE: Pachydermoperiostosis (PDP) is a rare genetic disorder characterized by the triad of pachyderma, digital clubbing, and periostosis. We report the case of a 17-year-old male who presented with classic clinical features over 3 years, including progressive skin thickening on the forehead, joint pain and swelling, hyperhidrosis, and facial oiliness, leading to a clinical and radiological… Read on PubMed →
A skin-hypothalamus axis couples heat stress and metabolic dysfunction.
Cell · 2026
With the ongoing rise in global temperatures, the prevalence of heat-stress-related chronic health disorders has increased. However, whether heat stress has an enduring impact on metabolic health remains unclear. Here, we report that mice exposed to heat stress were more susceptible to metabolic dysfunction upon subsequent exposure to an obesogenic diet. Upon heat stress, we found that elevated… Read on PubMed →
DGAT1 regulates keratinocyte proliferation through the modulation of retinoid homeostasis.
Journal of physiology and biochemistry · 2026
Multiple mechanisms contribute to skin barrier integrity, and emerging evidence suggests that acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) plays a key role in its regulation through both lipid and retinoid metabolism. Although DGAT1 deficiency leads to cutaneous abnormalities, the direct role of DGAT1 in keratinocyte biology remains unclear. Here, we show that DGAT1 deficiency drives… Read on PubMed →
Efficacy and Safety of Clascoterone Cream 1% and Adapalene Gel 0.3% in Patients With Acne.
Journal of drugs in dermatology : JDD · 2026
BACKGROUND: Clascoterone cream 1% is a topical androgen receptor inhibitor approved for the treatment of acne vulgaris in patients ≥12 years of age. The American Academy of Dermatology recommends topical combination therapy using medications that target different mechanisms of acne pathogenesis. This 20-week, open-label, pilot study (NCT06336603) evaluated the efficacy and safety of… Read on PubMed →
A Novel Retinoid and Salicylic Acid Topical Treatment for Moderate-Severe Acne.
Journal of drugs in dermatology : JDD · 2026
BACKGROUND: Advances in biotechnology have enabled highly effective, site-specific topical therapies for skin disease. Particle-based delivery systems can be engineered with tailored physicochemical properties and surface modifications to optimize controlled drug release and skin targeting, potentially improving acne treatment outcomes. OBJECTIVE: To evaluate the effectiveness and tolerability of… Read on PubMed →
The history, development and current status of isotretinoin: a review article.
Clinical and experimental dermatology · 2026
Isotretinoin, a potent retinoid, is highly effective in the treatment of severe acne vulgaris. Its nearly 60-year history began with the Swiss pharmaceutical company La Roche in the 1960s, where it was initially studied for potential benefits in cancer treatment. This article delineates the historical trajectory of isotretinoin from early clinical trials in the 1970s and 1980s, highlighting its… Read on PubMed →
Knufia epidermidis Infection: A Case Report and Literature Review.
The American journal of tropical medicine and hygiene · 2026
A 16-year-old male patient was admitted to the study hospital with a 6-month history of two itchy, round, xerotic lesions affecting the skin on his wrists. A definite diagnosis was not made in the local hospital, and antibiotics were administered without improvement. Using mycological culture and intergenic transcriptional space sequencing, the patient was diagnosed with a Knufia epidermidis (K… Read on PubMed →
Silk Sericin Functionalized with Carboxy Drugs for Dermocosmetic Applications.
ACS applied bio materials · 2026
Silk sericin protein, a textile industry by-product showing no toxicity on oral/topical administration, has recently been exploited as a drug delivery system. The high serine content in sericin makes its functionalization through covalent ester-type bonds feasible; however, only in a few cases have covalent conjugates of sericin with the drug to be delivered been developed. In this paper, we… Read on PubMed →
Vitamin A: Biological Functions and Implications for Muscle Health.
Nutrition reviews · 2026
Skeletal muscle diseases represent a diverse group of conditions, often characterized by muscle weakness, atrophy, and functional impairment. These disorders continue to impose a significant burden on global health, affecting millions of individuals worldwide. As the prevalence of muscle-related diseases rises, it becomes increasingly important to understand the complex biological mechanisms that… Read on PubMed →
Treatment of Confluent and Reticulated Papillomatosis Using Fixed-Dose Clindamycin phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel.
Journal of drugs in dermatology : JDD · 2026
INTRODUCTION: Confluent and reticulated papillomatosis (CARP) is a rare, non-systemic disease usually treated using oral antibiotics. CASE PRESENTATION: We present a 15-year-old male with CARP for whom initial treatment with doxycycline, ketoconazole shampoo, and topical minocycline was ineffective. He was subsequently treated with a combination of fixed-dose triple-combination clindamycin… Read on PubMed →
Malassezia Folliculitis Presentation, Diagnosis, and Treatment: A Review of "Fungal Acne".
Journal of drugs in dermatology : JDD · 2026
BACKGROUND: Malassezia folliculitis (MF), commonly referred to as "fungal acne" is a dermatological condition caused by colonization of the commensal fungus Malassezia, which turns pathogenic under certain conditions. MF presents as pruritic, erythematous papules and pustules and is often mistaken for other dermatological conditions, including acne vulgaris (AV). Interest in MF has intensified in… Read on PubMed →
Routine blood monitoring in acne vulgaris patients on isotretinoin: Is reassessment warranted? A retrospective cohort study from Tygerberg Hospital.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde · 2026
BACKGROUND: Oral isotretinoin is an indispensable treatment for patients with resistant and severe acne vulgaris, both in South Africa (SA) and globally. While routine laboratory monitoring is often deemed unnecessary for young, healthy patients, it remains unclear whether this applies in the SA context. OBJECTIVES: To assess the need for routine blood monitoring for acne vulgaris patients on… Read on PubMed →
Mechanistic Insights Into the Photosensitizing Properties of the Topical Retinoid Tazarotene.
ChemMedChem · 2026
Since the FDA approval of tretinoin in 1971, retinoids have been key in treating acne and different skin pathologies. Tazarotene (TZE), a third-generation retinoid and prodrug, is converted in the skin to its active form, tazarotenic acid (TZA). Its structure allows absorption of UVA/UVB light, prompting concerns about potential phototoxicity, but data on the excited state properties of TZE and… Read on PubMed →
Tower-shaped super-adhesive microneedles loaded with vitamin A-containing Bletilla striata vesicles: temporally regulated Inflammation resolution and ECM remodeling for scarless wound healing.
Journal of nanobiotechnology · 2026
Pathological scars, resulting from abnormal collagen metabolism during wound healing, pose clinical challenges due to the high recurrence rates of conventional treatments. Therefore, early-stage modulation of the wound healing process is emerging as a pivotal strategy for preventing and treating pathological scars, necessitating precise coordination of vascular regeneration, inflammation… Read on PubMed →
Inhibiting LSD1 unlocks retinoid AP-1 programming to activate epithelial immunity and skin tumor suppression.
The Journal of clinical investigation · 2026
Lysine-specific demethylase 1 (LSD1; KDM1A) orchestrates context-dependent chromatin programs, yet its role in epithelial immunity remains largely unknown. Here, we identify LSD1 as a central brake on retinoid-driven and activator protein-1-driven (AP-1-driven) enhancer activation in epidermis and demonstrate that its inhibition induces antitumor immunity. Whereas epidermal LSD1 is required during… Read on PubMed →
Metabolic adaptation drives self-organization during skin organoid morphogenesis.
Nature communications · 2026
Self-organization in organoid morphogenesis involves the coordinated arrangement of interacting cells into higher-order structures, yet the underlying principles remain elusive. Here, we investigate how epidermal and dermal cells respond distinctively to elevated levels of hypoxia during skin organoid morphogenesis that largely resembles the skin development during embryogenesis. We unveil that… Read on PubMed →
Retinoic acid at the crossroads of reproduction and sleep: an underexplored link with clinical implications.
Reproduction (Cambridge, England) · 2026
Retinoic acid, a vitamin A derivative widely used in dermatology, plays essential roles in female and male reproductive physiology and in the regulation of circadian rhythms. Emerging evidence suggests that chronic exposure to systemic retinoids, such as isotretinoin, may influence fertility parameters and sleep-reproductive interactions, highlighting the need for greater clinical awareness and… Read on PubMed →