Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
49 papers under Skin barrier
Ethnopharmacological investigation of Elaeocarpus sylvestris leaf extract in mitigating atopic dermatitis-like lesions via inflammatory signaling modulation.
Journal of ethnopharmacology · 2026
ETHNOPHARMACOLOGICAL RELEVANCE: Historically, Elaeocarpus sylvestris has served as a traditional medicinal agent for inflammatory disorders across East Asia. Recent studies have reported its antioxidant and anti-inflammatory activities, supporting its potential as a natural therapeutic resource for inflammatory skin diseases such as atopic dermatitis (AD). However, its pharmacological relevance to… Read on PubMed →
Kirenol, a diterpene active component from Siegesbeckia orientalis, alleviates atopic dermatitis by suppressing TYK2.
International immunopharmacology · 2026
BACKGROUND: Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease characterized by severe pruritus, skin barrier dysfunction, and underlying immune dysregulation. Kirenol, a major active ingredient and quality control marker from Siegesbeckia orientalis L., has been shown to possess broad pharmacological properties, ranging from anti-arthritic and anti-tumor activities to… Read on PubMed →
Mechanistic insights into triclocarban-induced skin barrier disruption via integrating imaging localization, multi-omics, and network toxicology.
Environmental pollution (Barking, Essex : 1987) · 2026
Humans are constantly exposed to the antimicrobial agent triclocarban (TCC) through dermal exposure to a range of household-cleaning and personal-hygiene products, but its potential effects on skin tissue still remain elusive. Here, we employed an integrated multi-omics and network toxicology strategy to explore the cutaneous toxicity of TCC and its underlying mechanisms. Atmospheric pressure… Read on PubMed →
Synergistic effects of glucocorticoid and N2-gas cold atmospheric plasma in a mouse model of atopic dermatitis.
International immunopharmacology · 2026
Atopic dermatitis (AD) is characterized by impaired skin barrier function, chronic inflammation, and increased susceptibility to infection. Although topical glucocorticoids are effective, long-term use is limited by adverse effects, highlighting the need for steroid-sparing strategies. This study investigated the immunomodulatory and therapeutic effects of nitrogen-based cold atmospheric plasma… Read on PubMed →
Protective effect of (-)-Loliode isolated from Sargassum horneri against particulate matter-induced skin damage via inhibiting pro-inflammatory cytokines and matrix metalloproteinases expression.
Chemico-biological interactions · 2026
Particulate matter (PM) is a pervasive carcinogen that can exacerbates skin inflammation, oxidative damage with extracellular matrix (ECM) degradation, thereby compromising skin barrier integrity and promoting premature aging. In this study, the protective potential and mechanistic basis of (-)-Loliode separated from Sargassum horneri, used for PM-induced skin injury is investigated. In vitro… Read on PubMed →
Microneedle array platforms for drug delivery and biomarker sensing: From skin mechanics guided design to scalable manufacture for clinical utility.
Journal of controlled release : official journal of the Controlled Release Society · 2026
Microneedle (MN) devices provide a platform for development of products that can facilitate intra-and trans-dermal delivery and sampling of active pharmaceutical ingredient (APIs) and biomarkers that would otherwise be restricted by the skin barrier. Despite significant progress in the development of laboratory-based prototypes, no Microneedle Array Patch (MAP) drug delivery products have been… Read on PubMed →
Evaluation of antioxidant-enriched cream formulations and their clinical effects in mild to moderate atopic dermatitis.
International journal of pharmaceutics · 2026
Topical antioxidant-containing creams have been investigated as adjunctive treatments for atopic dermatitis, but clinical efficacy remains inconsistent. In this study, a plant extract mixture containing epigallocatechin gallate, kaempferol, quercetin, and phlorizin was incorporated into two different base formulations and compared with their respective vehicles using ex vivo, in vitro and in vivo… Read on PubMed →
Composition and structure of stratum corneum intercellular lipids in patients with osimertinib-induced hand-foot syndrome.
Cancer chemotherapy and pharmacology · 2026
PURPOSE: Osimertinib (OSM), a third-generation epidermal growth factor receptor tyrosine kinase inhibitor, causes skin disorders, such as hand-foot syndrome (HFS), which impairs skin barrier function. Stratum corneum (SC) lipids play an important role in skin barrier function. This study aimed to compare the SC lipid composition and structure of healthy participants with those of patients with… Read on PubMed →
IL-4/IL-13-Driven Dysregulation of Epidermal Lipid Metabolism in Atopic Dermatitis: An Immunometabolic Link Between Type 2 Inflammation and Barrier Dysfunction.
Cells · 2026
Atopic dermatitis (AD) is a chronic immune-mediated inflammatory skin disease characterized by a complex and dynamic interplay between immune dysregulation and epidermal barrier dysfunction. Emerging evidence supports an integrated pathogenic model in which immune activation and barrier impairment form a bidirectional and self-reinforcing axis rather than representing separate processes. This… Read on PubMed →
Bloodstream Infection in an Immunocompromised Host After Unusual Presentation of Photo Recall Dermatitis.
The American journal of case reports · 2026
BACKGROUND Photo recall dermatitis (PRD) is a phototoxic eruption that occurs in areas of previous ultraviolet-damaged skin following systemic administration of a drug, most commonly chemotherapeutic medications. Although generally considered a self-limited dermatologic phenomenon, its implications in immunocompromised patients have not been well characterized. Secondary infection complicating PRD… Read on PubMed →
Development of AI-assisted 3D-printed degradable hydrogel microneedles for transdermal delivery of progesterone-loaded solid lipid nanoparticles: a novel approach to slowing Alzheimer's disease progression.
International journal of pharmaceutics · 2026
Progesterone (PG) is used to slow the progression of neurodegenerative diseases, particularly Alzheimer's disease (AD) in postmenopausal women. However, PG exhibits high lipophilicity, resulting in strong binding to skin tissues and plasma proteins, which may limit its systemic transport via transdermal routes. Solid lipid nanoparticles (SLNs) have been highlighted for their potential to enhance… Read on PubMed →
Neoagarotetraose from Marine Red Algae Ameliorates UVB-Induced Skin Barrier Damage in Mice and HaCaT Keratinocytes.
Marine biotechnology (New York, N.Y.) · 2026
Ultraviolet B (UVB) radiation is a major environmental threat that disrupts skin integrity and drives inflammatory skin disorders. Neoagarotetraose (NA4), a low-molecular-weight oligosaccharide derived from marine red algae, is characterized by high bioavailability and well-documented anti-inflammatory properties, yet its role in UVB-induced skin damage remains unexplored. In this study, we… Read on PubMed →
Atopic dermatitis.
Nature reviews. Disease primers · 2026
Atopic dermatitis (AD) is the most common inflammatory skin disease and carries the highest disability-adjusted life-years burden, ranking 15th among all non-fatal diseases globally. It is characterized by intensely itchy skin and is associated with multiple comorbidities, such as food allergy, asthma, allergic rhinitis and eosinophilic oesophagitis, which are mainly driven by type 2 immune… Read on PubMed →
Decoding Cyclodextrins in Skin Applications: Structure, Mechanisms, and Safety in Cosmetic and Dermatologic Formulations (Part I).
International journal of molecular sciences · 2026
Cyclodextrins (CDs) have emerged as important encapsulation platforms in dermatologic and cosmetic sciences, addressing critical challenges related to the solubility and stability of bioactive compounds. This review (Part I) systematically explores the relationship between the molecular architecture of CDs and their functional performance at the skin interface. A comprehensive analysis of the… Read on PubMed →
Transdermal drug delivery systems in cancer therapy: advances, challenges, and future perspectives.
European journal of clinical pharmacology · 2026
Conventional cancer therapies, particularly oral and intravenous chemotherapy, are frequently associated with systemic toxicity, non-specific drug distribution, fluctuating plasma concentrations, and limited patient compliance. These drawbacks have led to the development of alternative drug delivery strategies which aimed at improving therapeutic potency with minimized adverse effects. Transdermal… Read on PubMed →
High-level secretory production of a highly hydrophilic human-like type III collagen in Komagataella phaffii by a multicopy genomic integration strategy.
Biotechnology letters · 2026
Collagen, a key extracellular matrix protein, regulates cell adhesion, proliferation, and tissue integrity for skin health. In this study, a novel human-like type III collagen was engineered by substituting hydrophobic GXY triplets in the core fragment (Gly201-Asn498) of the human α1(III)type chain with hydrophilic motifs (GSP, GQP, GEP, and GSQ) and incorporating integrin-binding sequences (GER… Read on PubMed →
Development of IgE autoantibodies in newborns with atopic dermatitis (DIANA): protocol of a prospective, non-interventional, observational birth cohort.
BMJ open · 2026
INTRODUCTION: Atopic dermatitis (AD) is a chronic, pruritic inflammatory skin disorder that typically begins in early childhood and affects up to 20% of children. Infants with a family history of allergic diseases or with elevated total IgE levels are at increased risk of developing AD. Emerging evidence shows that a subgroup of AD patients produce IgE autoantibodies against skin self-peptides… Read on PubMed →
An Aqueous Extract of Beta vulgaris subsp. Vulgaris Beetroot Group Reduces Lipid Accumulation in Human Keratinocyte Cells.
International journal of molecular sciences · 2026
Epidermal lipid homeostasis is crucial for skin barrier integrity. This study investigated the effects of an aqueous extract from Beta vulgaris subsp. vulgaris Beetroot Group (BvE) on stress responses and lipid metabolism in HaCaT keratinocytes. BvE, obtained from leaves grown in SETIS® bioreactors as a standardized biomass source, was chemically characterized by 1H NMR and 13C NMR. HaCaT cells… Read on PubMed →
Climate, Humidity, and Population-Level Interest in Dry Skin: Infodemiology Analysis Using Google Trends Across the United States.
JMIR dermatology · 2026
BACKGROUND: Climate and weather factors of temperature and humidity are widely reported to be associated with xerosis (dry skin), a common inflammatory skin condition and frequent driver of pruritus (itchy skin) and reduced quality of life. Growing evidence supports links between environmental conditions and skin barrier function, with extreme climates associated with increased atopic… Read on PubMed →
Tryptophan Metabolism at the Crossroads of Immunity, Barrier Function, and the Microbiome in Atopic Dermatitis.
Clinical reviews in allergy & immunology · 2026
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by complex interplay among immune imbalance, impaired barrier function, and alterations in host‒microbiome interactions. Accumulating evidence indicates that tryptophan (TRP) metabolism is associated with these core pathological processes. This review summarizes the major TRP metabolic pathways, including the kynurenine… Read on PubMed →