Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
374 papers
Evaluation of antioxidant-enriched cream formulations and their clinical effects in mild to moderate atopic dermatitis.
International journal of pharmaceutics · 2026
Topical antioxidant-containing creams have been investigated as adjunctive treatments for atopic dermatitis, but clinical efficacy remains inconsistent. In this study, a plant extract mixture containing epigallocatechin gallate, kaempferol, quercetin, and phlorizin was incorporated into two different base formulations and compared with their respective vehicles using ex vivo, in vitro and in vivo… Read on PubMed →
The Rise in Homemade Sunscreen Trends and Future Impacts on Skin Cancer Risk: Systematic Review.
JMIR dermatology · 2026
BACKGROUND: The trend of homemade sunscreen recipes has rapidly gained popularity over the last decade, being largely fueled by social media influencers, natural health blogs, and the growing mistrust of large health organizations like the US Food and Drug Administration (FDA). Consumers are increasingly drawn to products labeled "natural," "organic," "vegan," and "cruelty-free," often conflating… Read on PubMed →
Composition and structure of stratum corneum intercellular lipids in patients with osimertinib-induced hand-foot syndrome.
Cancer chemotherapy and pharmacology · 2026
PURPOSE: Osimertinib (OSM), a third-generation epidermal growth factor receptor tyrosine kinase inhibitor, causes skin disorders, such as hand-foot syndrome (HFS), which impairs skin barrier function. Stratum corneum (SC) lipids play an important role in skin barrier function. This study aimed to compare the SC lipid composition and structure of healthy participants with those of patients with… Read on PubMed →
Injectable Therapy for Androgenetic Alopecia: A Systematic Review.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2026
BACKGROUND: Androgenetic alopecia (AGA) is the leading cause of patterned hair loss. Current therapies are limited, and injectable therapy has emerged for intradermal delivery of bioactive agents. Despite increasing use, protocols and outcomes remain heterogeneous. OBJECTIVE: To systematically evaluate the agents, techniques, efficacy, and adverse effects of injectable therapy for AGA. MATERIALS… Read on PubMed →
Matrix-tuned hyaluronic nanofibrils promoting regenerative ocular surfacing with minimal scarring.
Biofabrication · 2026
Corneal epithelial damage remains a considerable clinical challenge, often leading to delayed wound healing and impaired vision. Hyaluronic acid (HA)-based nanofibers face fabrication and stability challenges, reducing their translational potential for corneal regeneration. The fabrication and characterization of aminolyzed polycaprolactone (PCL) nanofibrils (aNFs) with manipulated HA conjugation… Read on PubMed →
Wearable near-infrared LED photothermal microneedle patch reduces periorbital wrinkles in a randomized pilot clinical trial.
Journal of materials chemistry. B · 2026
Microneedle patches are typically passive, limiting control over dissolution kinetics and transdermal transport. Here we introduce a wearable, actively actuated microneedle system in which dissolving hyaluronic-acid tips penetrate the stratum corneum while a hydrocolloid backing embedded with hyaluronic-acid-gold-nanorod (HA-GNR) nanocomposites provides near-infrared (NIR, ≈780 nm) photothermal… Read on PubMed →
Comparing a Red and Blue Light-Emitting Diode Light Device With an Existing Blue Light Device for At-Home Treatment of Inflammatory Acne: An Open-Label Randomized-Controlled Trial.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2026
BACKGROUND: Red and blue light have beneficial, complementary effects on acne. OBJECTIVE: To evaluate the efficacy and safety of at-home treatment of mild-to-moderate inflammatory acne with an investigational combination 660-nm red/415-nm blue light-emitting diode device (RBL) compared with a commercially available 415-nm blue light-emitting diode device (BL). MATERIALS AND METHODS: This was an… Read on PubMed →
Sakuranin attenuates UVB-induced skin damage by preserving mitochondria-ER coupling and restoring redox-organelle homeostasis.
International immunopharmacology · 2026
Ultraviolet B (UVB) irradiation elicits complex intracellular stress responses that drive keratinocyte injury and skin photoaging through coordinated disruption of redox homeostasis, mitochondrial dynamics, and endoplasmic reticulum (ER) stress signaling at mitochondria-ER contact sites. This study investigated whether sakuranin (SKR), a naturally occurring flavanone glycoside, exerts… Read on PubMed →
Enhanced biodistribution and efficacy of nicomenthyl encapsulated in emulsions stabilized by methacrylated hyaluronic acid for the prevention and treatment of skin photoaging.
Carbohydrate polymers · 2026
Nicomenthyl (NM), prodrug of niacinamide (vitamin B3), is widely used in skin applications for their biological benefits, but remain mainly in the stratum corneum (SC). Bioactive methacrylate-functionalized hyaluronic acid (HA-MA) (44.5 KDa; degree of substitution: 80-100%), used to stabilize Oil-in-Water emulsions (EM) as new application for polysaccharide, represent an effective strategy to… Read on PubMed →
Pediatric Genital Endemic Kaposi Sarcoma with Partial Response to Adapalene.
The American journal of tropical medicine and hygiene · 2026
Kaposi sarcoma (KS) is a human herpesvirus 8 (HHV-8)-associated vascular neoplasm that most commonly affects immunocompromised individuals. Endemic KS occurs in sub-Saharan Africa but rarely involves the anogenital region in pediatric patients. We report a case of a 12-year-old immunocompetent Ghanaian girl presenting with rapidly progressive nodular and fungating masses involving the trunk and… Read on PubMed →
Exosome-driven treatments for hair regrowth in androgenetic alopecia: a systematic review of preclinical studies, clinical experiments, safety, and future prospects.
Molecular biology reports · 2026
BACKGROUND: Androgenetic alopecia (AGA) imposes a significant psychosocial burden, yet current treatments such as minoxidil and finasteride often yield suboptimal responses or adverse effects. Exosomes, nanoscale extracellular vesicles derived from mesenchymal stem cells and dermal papilla cells (DPCs), offer a promising regenerative alternative by modulating key hair-growth pathways. This… Read on PubMed →
Topical Recombinant Collagen Following Fractional Radio Frequency Microneedling for Nonsurgical Facelift: Case Report.
JMIR dermatology · 2026
BACKGROUND: Fractional radio frequency microneedling (FRM) is an effective nonsurgical facelift modality supported by growing clinical evidence. While generally well tolerated, postprocedural erythema, pain, swelling, and bruising typically last up to 7 days. Other serious complications include prolonged swelling, infection, persistent grid mark, burns, and hypo- or hyperpigmentation. Recombinant… Read on PubMed →
Acquired dermal macular hyperpigmentation: a unified spectrum of dermal pigmentary dermatoses.
Clinical and experimental dermatology · 2026
Acquired dermal macular hyperpigmentation (ADMH) encompasses a group of dermal pigmentary disorders (lichen planus pigmentosus, erythema dyschromicum perstans and Riehl melanosis/pigmented cosmetic dermatitis) that present with insidious-onset grey-to-brown macules and patches due to dermal melanin deposition. Traditionally regarded as distinct entities, these disorders share overlapping clinical… Read on PubMed →
The efficacy of tranexamic acid in prevention and treatment of post-inflammatory hyperpigmentation: a pilot study.
Clinical and experimental dermatology · 2026
Post-inflammatory hyperpigmentation (PIH) is a common complication following trauma or cutaneous inflammation, particularly affecting individuals with skin of colour. Tranexamic acid (TXA) is a lysine analogue with antifibrinolytic properties and has been used as an off-label agent for melasma and procedural PIH. This pilot study evaluated the efficacy of oral TXA in the prevention and treatment… Read on PubMed →
Ultraviolet arrows signal immediate, ever-present danger: development and evaluation of a skin cancer prevention campaign to improve young adults' sun protection in Australia.
Public health research & practice · 2026
OBJECTIVES AND IMPORTANCE OF STUDY: Melanoma of the skin is highly preventable, with >97% of cases in Australia/New Zealand caused by overexposure to ultraviolet radiation. Young adults aged 18-24 years are at greater risk of overexposure than older adults due to lower use of some forms of sun protection, spending more time in the sun, and being more likely to attempt tanning and experience… Read on PubMed →
Preclinical development of a 3D-printed hollow microneedle platform for intradermal delivery of antioxidant-loaded nanocarriers.
International journal of pharmaceutics · 2026
The poor penetration of topical antioxidants underscores the need for advanced intradermal delivery platforms that overcome stratum corneum limitations while protecting labile compounds. Despite their efficacy, in-clinic treatments (microneedling, laser, injections) require frequent administration and entail high costs. Hollow microneedles (HMNs) provide a minimally invasive, precise, and… Read on PubMed →
Chemoprevention of keratinocyte carcinomas and actinic keratoses in adults who were immunocompetent: a systematic review.
Clinical and experimental dermatology · 2026
BACKGROUND: Keratinocyte carcinomas (KCs), comprising basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are the most common skin cancers worldwide. Actinic keratoses (AKs) are precursors to SCCs and markers of cumulative ultraviolet damage. Chemoprevention has been explored in cohorts who are high risk or immunosuppressed, however, their value in adults who are immunocompetent remains… Read on PubMed →
Antibiotic-induced Malassezia expansion in the infant gut promotes early-life immune dysregulation and airway inflammation in mice.
Nature communications · 2026
Antibiotics have deleterious consequences for the gut microbiome and can increase the risk of childhood asthma. While the effects of antibiotics on the bacterial microbiome and asthma risk are well characterized, their impact on the fungal microbiome (mycobiome) remains vastly unexplored. We investigated the effect of antibiotic use on the gut mycobiome in an observational, prospective clinical… Read on PubMed →
Mechanistic study on hyaluronic acid polysiloxane gel promoting wound repair guided by wet healing theory.
Biomedical materials (Bristol, England) · 2026
As a vital barrier organ of the human body, skin wound repair faces clinical challenges such as slow healing, scar hyperplasia, and infection. Although the wet healing theory has confirmed that a moist environment can enhance epidermal cell migration and reduce infection rates, the action mechanism of composite functional dressings still lacks systematic analysis. This study focuses on hyaluronic… Read on PubMed →
Comparing fractional CO₂ laser and needling-based modalities in facial acne scar treatment: a comprehensive systematic review and meta-analysis.
Lasers in medical science · 2026
Facial acne scarring is a widely prevalent dermatological disease manifested as a permanent aftereffect of acne vulgaris. While fractional CO₂ laser and needling procedures are essential to treating atrophic acne scars, comparative and safety data remains limited. This systematic review and meta-analysis directly compares their efficacy and safety. According to PRISMA guidelines, PubMed, Cochrane… Read on PubMed →