Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
130 papers under Contact allergy
Regulatory frameworks for fragrance safety in cosmetics: a global overview.
Toxicological research · 2025
Fragrances play a crucial role in cosmetic products, influencing consumer preferences and enriching sensory experiences. However, making sure these products are safe, especially concerning natural and synthetic fragrances, requires robust regulatory frameworks. This review offers a global perspective on the regulatory systems governing the safety of fragrances. It begins by examining the… Read on PubMed →
Extended fragrance ingredients surveillance study (EFISS)-protocol for a clinical surveillance study on contact allergy to 7 fragrance materials in widespread use but hitherto not systematically patch tested.
Archives of dermatological research · 2025
Contact allergy (CA) is not uncommon in the population, including to various fragrance allergens. If not diagnosed correctly, allergic contact dermatitis (ACD) may ensue, because targeted allergen avoidance is not possible. The primary objective of the study is to estimate the prevalence of CA to seven fragrance materials in patients with suspected ACD across Europe. Based on the outcome, a… Read on PubMed →
Trends in Contact Allergy to Preservatives From 2014 to 2023: Benzisothiazolinone on the Rise.
Contact dermatitis · 2025
<h4>Background</h4>Skin sensitising preservatives are commonly used in consumer and industrial products. The widespread use of preservatives has led to recurrent epidemics of contact allergy.<h4>Objectives</h4>To investigate temporal trends of contact allergy to preservatives from 2014 to 2023.<h4>Materials and methods</h4>Patients consecutively patch tested with preservatives from the European… Read on PubMed →
Para-Phenylenediamine Sensitization and Polysensitization: TNF-α, CXCL11, and Immune-Regulatory Gene Polymorphisms.
Annals of dermatology · 2025
<h4>Background</h4>Para-phenylenediamine (PPD) is a major hair dye allergen and often heralds broader contact allergy risk, yet the links among PPD sensitization, polysensitization (PS) and host genetics remain understudied.<h4>Objective</h4>To quantify the association between PPD sensitization and PS in Korean patch test patients and to explore whether single nucleotide polymorphisms (SNPs) in… Read on PubMed →
What is New in Contact Allergy To Cosmetics for Physicians, Cosmetologists, and Cosmetic Users?
Current allergy and asthma reports · 2025
<h4>Purpose of review</h4>This paper aims to evaluate the burden of contact allergy caused by cosmetic products, identifying the key allergens involved and examining recent regulatory and diagnostic developments. The review addresses which substances commonly induce allergic contact dermatitis and how current trends and emerging allergens impact clinical practice.<h4>Recent findings</h4>Fragrances… Read on PubMed →
Toluene-2,5-Diamine Sulfate: The 2025 American Contact Dermatitis Society Allergen of the Year.
Cutis · 2025
The American Contact Dermatitis Society named toluene-2,5-diamine sulfate (PTDS) the 2025 Allergen of the Year. Toluene-2,5-diamine sulfate is widely used as an alternative to para-phenylenediamine (PPD) in hair dyes but is itself a potent and likely underreported contact allergen. Cross-reactivity with PPD is common. Allergic contact dermatitis to PTDS manifests similarly to PPD reactions and… Read on PubMed →
Clinical Evaluation, Patch Testing, and Quality of Life Assessment in Patients With Cosmetic Dermatitis.
Cureus · 2024
Background Cosmetics have become an integral part of the contemporary lifestyle. Contact dermatitis (CD) is an inflammatory skin disease resulting from exposure to an external chemical present in cosmetics. A patch test is considered the criterion standard method for detecting CD. CD has been demonstrated to be detrimental to the quality of life (QoL). Objective The present study aims to… Read on PubMed →
Contact sensitization to fragrance mix I and fragrance mix II among European dermatitis patients: A systematic review.
Contact dermatitis · 2024
<h4>Background</h4>Fragrance substances are a frequent cause of contact allergy worldwide. Fragrance exposure varies by sex, age and possibly country, influenced by cosmetic availability, environmental conditions and cultural practices.<h4>Objectives</h4>To systematically review and gather prevalence of sensitization to fragrance mix I (FM I) and fragrance mix II (FM II) in consecutively patch… Read on PubMed →
Fragrance Contact Allergy - A Review Focusing on Patch Testing.
Acta dermato-venereologica · 2024
Fragrance materials are widely used in various types of products in daily life and many of them can be contact sensitizers. Contact allergy to fragrances has been reported to be common worldwide. Unlike other groups of contact allergens such as metals and preservatives, fragrance materials in consumer products can be present as single fragrance chemicals or in the form of mixtures known as natural… Read on PubMed →