Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
374 papers
Proteomic Analysis of the Metabolic Response of UVA-Exposed Melanocytes Following Co-Treatment with Cannabigerol and 3-O-Ethylascorbic Acid.
Cells · 2026
The aim of this study was to analyze the effect of concomitant use of cannabigerol (CBG) and 3-O-ethylascorbic acid (EAA) on changes in the proteome of UVA-irradiated skin melanocytes, with particular emphasis on adduct formation between lipid peroxidation products and metabolically important proteins. Proteomic analysis allowed the identification of 1248 proteins with statistically significantly… Read on PubMed →
Tryptophan Metabolism at the Crossroads of Immunity, Barrier Function, and the Microbiome in Atopic Dermatitis.
Clinical reviews in allergy & immunology · 2026
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by complex interplay among immune imbalance, impaired barrier function, and alterations in host‒microbiome interactions. Accumulating evidence indicates that tryptophan (TRP) metabolism is associated with these core pathological processes. This review summarizes the major TRP metabolic pathways, including the kynurenine… Read on PubMed →
Efficacy and safety of recombinant human epidermal growth factor combined with fractional carbon dioxide laser for facial atrophic acne scars: a systematic review and meta-analysis of randomized trials.
Lasers in medical science · 2026
BACKGROUND: The combination of recombinant human epidermal growth factor (rhEGF) and fractional carbon dioxide (CO2) laser therapy is increasingly used in the treatment of facial atrophic acne scars. OBJECTIVE: This study aimed to systematically assess the efficacy and safety of rhEGF combined with fractional CO2 laser therapy for managing facial atrophic acne scars. METHODS: PubMed, Embase, the… Read on PubMed →
Estimating Transepidermal Water Loss from Smartphone Facial Images Using Self-Supervised Features and a Mixture Density Network.
Studies in health technology and informatics · 2026
Skin conditions fluctuate daily, and the subtle changes are difficult to detect. Transepidermal water loss (TEWL), a key indicator of skin barrier function, is effective for monitoring these changes; however, its measurement requires specialized and costly equipment, making daily implementation impractical. This study aimed to develop and evaluate a machine-learning model for estimating TEWL from… Read on PubMed →
Konjac Ceramide Induces Semaphorin 3A Expression via the MAPK/AP-1 Signaling Axis and RORα in Normal Human Epidermal Keratinocytes.
Biomolecules · 2026
Epidermal hyperinnervation is a major cause of intractable itch in barrier dysfunction conditions such as atopic dermatitis. Keratinocyte-derived semaphorin 3A (Sema3A) suppresses epidermal hyperinnervation, but its expression is markedly reduced in barrier-disrupted skin. Although konjac ceramide (kCer) has been reported to act as a Sema3A-like ligand, the mechanisms by which it regulates Sema3A… Read on PubMed →
Combined conservative hemodynamic treatment for venous insufficiency strategy and negative-pressure wound therapy for the management of a refractory venous ulcer: a case report and review of the literature.
Journal of medical case reports · 2026
BACKGROUND: Chronic venous ulcers (CVUs), affecting 1-5% of adults, present significant management challenges due to delayed healing and high recurrence rates. Negative pressure wound therapy (NPWT) has emerged as a beneficial adjunct to compression therapy for refractory cases. CASE PRESENTATION: A 78-year-old Chinese female with a 30-year history of symptomatic bilateral varicose veins CEAP C6… Read on PubMed →
Prevalence and Context of Sunburn Among U.S. Adults - United States, 2024.
MMWR. Morbidity and mortality weekly report · 2026
Sunburn is an important risk factor for skin cancer. Understanding sunburn prevalence and the contexts in which sunburn commonly occurs might help guide the development and implementation of sun safety interventions. Data from the 2024 National Health Interview Survey sample adult questionnaire were analyzed to describe the prevalence of one or more and four or more sunburns among U.S. adults… Read on PubMed →
Understanding Infantile Atopic Dermatitis: A Review of Environmental, Familial, Genetic and Microbial Influences.
Current allergy and asthma reports · 2026
PURPOSE OF REVIEW: This review aims to clarify the early-life risk and protective factors associated with Infantile Atopic Dermatitis (IAD)-an inflammatory skin condition that typically develops between birth and two years of age. The goal was to examine recent findings on maternal, environmental, and microbial influences on IAD. RECENT FINDINGS: Prenatal and postpartum maternal probiotic use may… Read on PubMed →
A co-amorphous salt of ursodeoxycholic acid and matrine incorporated into dissolving microneedles for combined antibacterial and anti-inflammatory treatment of acne vulgaris.
International journal of pharmaceutics · 2026
Acne vulgaris is characterized by microbial dysbiosis and excessive inflammatory activation, whereas current topical therapies are often limited by poor skin penetration and increasing antibiotic resistance. Ursodeoxycholic acid (UDCA) has anti-inflammatory potential but suffers from low aqueous solubility and limited cutaneous permeability. In this study, a co-amorphous salt of UDCA and matrine… Read on PubMed →
Polysaccharide-Based Soluble Microneedle Transdermal Delivery of Curcumin Synergized with Photothermal Therapy for Acne Treatment.
ACS applied materials & interfaces · 2026
Acne is a chronic inflammatory skin disease driven primarily by Propionibacterium acnes (P. acnes) colonization in hair follicles, which can progress from mild to severe forms and result in permanent scarring if left untreated. To resolve this problem, this study developed a polysaccharide-based light-heat-mediated soluble microneedle system for the transdermal delivery of antiacne agents… Read on PubMed →
Protecting Skin from UV Exposure with Dietary Polyphenols: Comparison of Phenolic Metabolites in an Ex Vivo Skin Explant Model.
Journal of agricultural and food chemistry · 2026
Dietary berry consumption generates circulating gut-derived phenolic metabolites linked to systemic health benefits, yet their roles in enhancing skin resilience against environmental stressors are unclear. This study evaluated the protective effects of wild blueberry polyphenolic metabolites on ex vivo human skin biopsies exposed to ultraviolet irradiation. The metabolites were derived from… Read on PubMed →
Skin Staphylococcus species differentially modulate keratinocyte cytokine secretion in response to UVB.
Applied and environmental microbiology · 2026
Skin acts as the body's first line of defense against environmental insults including ultraviolet radiation (UVR) from sunlight and engages in a dynamic dialog with the resident skin microbiota, increasingly recognized for its role in shaping and educating the immune responses of the skin in both health and disease. However, how or indeed if the resident skin microbiota mediates inflammatory… Read on PubMed →
3D-Printed lesion-conformal light-guiding patches for precise and personalized psoriasis phototherapy.
Biomaterials science · 2026
Psoriasis is a chronic inflammatory skin disorder marked by epidermal hyperplasia and hyperkeratosis, with lesions presenting highly irregular geometric patterns and a discrete distribution. Traditional phototherapy, lacking spatial selectivity, often causes radiation damage to surrounding healthy tissue, thereby limiting treatment dosage and frequency. In this study, we developed… Read on PubMed →
Tear Trough Deformity: Update on Anatomy and Clinical Management.
Aesthetic surgery journal · 2026
Tear trough deformity represents a distinct and defining feature of lower eyelid aging and rejuvenation and is a frequent contributor to a fatigued or aged appearance. Management strategies vary widely, reflecting differences in patient anatomy, deformity severity, and surgical philosophy. This review updates contemporary anatomic concepts of the tear trough and integrates these findings with… Read on PubMed →
Efficacy of Japanese Maca Powder Against Aging Stress in Human Dermal Fibroblasts.
International journal of molecular sciences · 2026
The aim of this study was to identify and examine materials that have a long history of use in folk medicine and exhibit biological activity but have not been fully utilized. This study evaluated the reactivity of Japanese maca powder in cultured human dermal cells subjected to aging stress (UV irradiation, AGE treatment, or H2O2 treatment). The mRNA levels of three stress parameters (collagen… Read on PubMed →
Functional hyaluronic acid/gelatin hydrogel accelerates the closure and healing of diabetic wounds.
Carbohydrate polymers · 2026
The healing of extensive drug-resistant and skin area diabetic wounds poses significantly greater challenges compared to the recovery of typical wounds. Advanced approaches like tissue engineering and regenerative medicine hold promise, exemplified by hyaluronic acid/gelatin/poly(N-isopropyl acrylamide) (PNIPAm) hydrogel, a temperature-sensitive auto-shrinkage hydrogel with injectable biomimetic… Read on PubMed →
The Protective and Regenerative Potential of Lactoferrin in Hair and Skin Health.
International journal of molecular sciences · 2026
Lactoferrin is a naturally occurring bioactive glycoprotein that is part of the body's innate immune system and has essential roles in iron metabolism, microbial defense, inflammation regulation, and tissue repair. It supports the natural regulation of iron bioavailability in skin and hair follicles, helping to reduce excess free-iron-driven oxidative stress while preserving levels of necessary… Read on PubMed →
Salvage of preputial flap necrosis in penile glans melanosis using Integra dermal regeneration template and split-thickness skin graft: A case report.
Medicine · 2026
RATIONALE: Penile glans melanosis is a benign but psychologically distressing condition. While surgical excision with flap reconstruction is a standard treatment for extensive lesions, total flap necrosis presents a significant reconstructive challenge. This report describes a successful salvage strategy using a dermal regeneration template (Integra) and split-thickness skin grafting (STSG) after… Read on PubMed →
A flexible multichannel wearable sensor for real-time monitoring of exercise-induced sweat composition.
Talanta · 2026
To address low sensitivity, severe environmental interference, single-analyte detection, and traditional rigid substrates' inability to adapt to dynamic skin deformation in surface metabolite detection, polyethylene terephthalate (PET) was selected as the flexible substrate. A multi-channel flexible wearable biosensor with mechanical adaptability and multi-parameter detection capability was… Read on PubMed →
Bi-directional regulation between NAD/NAMPT and IFN-γ/PD-L1 axes via BRD4/IRF1 and mitochondrial respiration in metastatic cutaneous melanoma.
Journal of experimental & clinical cancer research : CR · 2026
BACKGROUND: Metastatic cutaneous melanoma (MCM) is primarily treated with BRAF/MEK inhibitors and immune checkpoint inhibitors (ICIs), but the long-term efficacy of these therapies is often limited by acquired resistance. Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in NAD biosynthesis, is frequently upregulated in MCM, supporting metabolic rewiring and targeted therapy… Read on PubMed →