Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
374 papers
Emerging Patterns in Dietary Supplement Use Among US Adults, 1999-2023.
JAMA network open · 2026
IMPORTANCE: Dietary supplement use is widespread among US adults, but long-term national data, particularly on emerging products and COVID-19-related changes, are limited. Understanding population-level changes is essential to inform research and public health priorities. OBJECTIVE: To evaluate 25-year trends in dietary supplement use among US adults. DESIGN, SETTING, AND PARTICIPANTS: This… Read on PubMed →
Transdermal drug delivery systems in cancer therapy: advances, challenges, and future perspectives.
European journal of clinical pharmacology · 2026
Conventional cancer therapies, particularly oral and intravenous chemotherapy, are frequently associated with systemic toxicity, non-specific drug distribution, fluctuating plasma concentrations, and limited patient compliance. These drawbacks have led to the development of alternative drug delivery strategies which aimed at improving therapeutic potency with minimized adverse effects. Transdermal… Read on PubMed →
Reversal of rare paraneoplastic syndromes in melanoma: fever and cutaneous melanosis.
Melanoma research · 2026
Paraneoplastic syndromes (PNS), manifestations of systemic effects of a tumor, are rare in patients with melanoma. We describe two cases of patients who presented with rare PNS, fever, and cutaneous melanosis, that resolved after treatment of melanoma. The first patient, a 64-year-old woman, presented with high fever. After diagnostic evaluation, infectious causes were excluded and the patient was… Read on PubMed →
Anti-Photoaging and Anti-Melanogenic Effects of a Novel Lactiplantibacillus plantarum RKBP Isolated from Giant Centella asiatica.
Journal of microbiology and biotechnology · 2026
Ultraviolet B (UVB) irradiation is a major contributor to photoaging and hyperpigmentation, leading to collagen damage and excessive melanin accumulation. This study investigated the anti-photoaging and anti-melanogenic effects of heat-killed L. plantarum RKBP isolated from Giant Centella asiatica. L. plantarum RKBP was prepared by thermal inactivation and evaluated for anti-photoaging effects… Read on PubMed →
Treating Acne Vulgaris and Scarring With Botulinum Toxin: A Systematic Review.
Journal of drugs in dermatology : JDD · 2026
BACKGROUND: Many treatments have been proposed for the treatment of acne vulgaris and acne scarring; however, few data exist regarding the efficacy of botulinum toxin A as a treatment option. OBJECTIVE: To compile all available data on the efficacy and safety of botulinum toxin A as a treatment for acne vulgaris and acne scarring. METHODS: A systematic review of PubMed/MEDLINE, Excerpta Medica… Read on PubMed →
Efficacy and Safety of Clascoterone Cream 1% and Clindamycin 1.2%/Benzoyl Peroxide 5% Gel Treatment in Patients With Acne.
Journal of drugs in dermatology : JDD · 2026
BACKGROUND: Clascoterone cream 1% is a topical androgen receptor inhibitor approved to treat acne vulgaris in patients ≥12 years of age. The American Academy of Dermatology recommends combining topical therapies that target different mechanisms of acne pathogenesis as first-line treatment for acne. This 16-week, open-label pilot study evaluated the efficacy and safety of clascoterone cream 1%… Read on PubMed →
Randomized Controlled Study of Bacteriophages in Acne Reveals Efficacy and Novel Mechanism for Promoting Long-Term Skin Health.
Journal of drugs in dermatology : JDD · 2026
BACKGROUND: Acne is the most prevalent skin disease globally, with a significant burden and limited therapeutic innovation. Although it has a multifactorial etiology, Cutibacterium acnes (C acnes) overgrowth is a key factor in driving inflammation in acne. Bacteriophages are a novel mechanism that can specifically target C acnes and are found in greater abundance on healthy skin compared to… Read on PubMed →
Understanding Patient Perspectives on Rosacea: A Cross-Sectional Analysis of the r/Rosacea Forum on Reddit.
Journal of drugs in dermatology : JDD · 2026
BACKGROUND: As the largest online rosacea forum, r/Rosacea, a subreddit hosted on Reddit, provides a unique opportunity to better understand the concerns of rosacea patients. METHODS: Using Python software and artificial intelligence models, a total of 1,000 posts from the r/Rosacea subreddit were analyzed for emotional tone, post category, and mentions of signs and symptoms, as well as… Read on PubMed →
A Randomized Controlled Trial Analyzing the Likeability, Usability, and In-Use Efficacy of Mineral Sunscreens Across Diverse Skin Tones.
Journal of drugs in dermatology : JDD · 2026
BACKGROUND: Mineral sunscreens are increasingly favorable among consumers. However, mineral sunscreens typically cause a white cast that can impact consumer selection and application. OBJECTIVE: This study measured the whitening effect of mineral sunscreens across diverse skin tones and evaluated its relationship with consumer perception, application behavior, and the product's efficacy in terms… Read on PubMed →
Topical Ascorbic Acid for Corneal Endothelial Cell Density Enhancement, Protection, and Recovery in Fuchs Dystrophy After Complicated Cataract Surgery.
Eye & contact lens · 2026
We report a case highlighting the potential of topical ascorbic acid (AA) as an adjunctive strategy for supporting corneal endothelial stability in Fuchs endothelial corneal dystrophy (FECD) after complicated cataract surgery. A 74-year-old man with bilateral FECD presented with progressive vision loss. Baseline endothelial cell density (ECD) was 1,996 cells/mm2 in the right eye and 1,988… Read on PubMed →
Efficacy and Safety of Clascoterone Cream 1% and Adapalene Gel 0.3% in Patients With Acne.
Journal of drugs in dermatology : JDD · 2026
BACKGROUND: Clascoterone cream 1% is a topical androgen receptor inhibitor approved for the treatment of acne vulgaris in patients ≥12 years of age. The American Academy of Dermatology recommends topical combination therapy using medications that target different mechanisms of acne pathogenesis. This 20-week, open-label, pilot study (NCT06336603) evaluated the efficacy and safety of… Read on PubMed →
A Novel Retinoid and Salicylic Acid Topical Treatment for Moderate-Severe Acne.
Journal of drugs in dermatology : JDD · 2026
BACKGROUND: Advances in biotechnology have enabled highly effective, site-specific topical therapies for skin disease. Particle-based delivery systems can be engineered with tailored physicochemical properties and surface modifications to optimize controlled drug release and skin targeting, potentially improving acne treatment outcomes. OBJECTIVE: To evaluate the effectiveness and tolerability of… Read on PubMed →
High-level secretory production of a highly hydrophilic human-like type III collagen in Komagataella phaffii by a multicopy genomic integration strategy.
Biotechnology letters · 2026
Collagen, a key extracellular matrix protein, regulates cell adhesion, proliferation, and tissue integrity for skin health. In this study, a novel human-like type III collagen was engineered by substituting hydrophobic GXY triplets in the core fragment (Gly201-Asn498) of the human α1(III)type chain with hydrophilic motifs (GSP, GQP, GEP, and GSQ) and incorporating integrin-binding sequences (GER… Read on PubMed →
Development of IgE autoantibodies in newborns with atopic dermatitis (DIANA): protocol of a prospective, non-interventional, observational birth cohort.
BMJ open · 2026
INTRODUCTION: Atopic dermatitis (AD) is a chronic, pruritic inflammatory skin disorder that typically begins in early childhood and affects up to 20% of children. Infants with a family history of allergic diseases or with elevated total IgE levels are at increased risk of developing AD. Emerging evidence shows that a subgroup of AD patients produce IgE autoantibodies against skin self-peptides… Read on PubMed →
Skin Cancer Prevention and Antiaging: Role of Nicotinamide.
International journal of molecular sciences · 2026
Nicotinamide (NAM), the amide form of vitamin B3, has gained increasing attention in dermatology due to its potential role in both skin aging and non-melanoma skin cancer (NMSC) prevention. This review summarizes the biological rationale and current clinical evidence supporting the use of NAM and other NAD+ precursors in photoaging and cutaneous carcinogenesis. Chronic ultraviolet exposure induces… Read on PubMed →
An Aqueous Extract of Beta vulgaris subsp. Vulgaris Beetroot Group Reduces Lipid Accumulation in Human Keratinocyte Cells.
International journal of molecular sciences · 2026
Epidermal lipid homeostasis is crucial for skin barrier integrity. This study investigated the effects of an aqueous extract from Beta vulgaris subsp. vulgaris Beetroot Group (BvE) on stress responses and lipid metabolism in HaCaT keratinocytes. BvE, obtained from leaves grown in SETIS® bioreactors as a standardized biomass source, was chemically characterized by 1H NMR and 13C NMR. HaCaT cells… Read on PubMed →
Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence.
International journal of molecular sciences · 2026
Skin aging stems from intrinsic decline and external stressors that induce oxidative stress and mitochondrial damage, ultimately lowering cellular energy production and slowing epidermal turnover to cause wrinkles, dryness, and pigment imbalances. While disodium adenosine monophosphate (AMP2Na) is hypothesized to enhance cellular adenosine triphosphate production and restore epidermal metabolism… Read on PubMed →
In Vitro Assessment of Stimulation of Collagen Biosynthesis via Collagenprash and Collagen Builder.
Journal of agricultural and food chemistry · 2026
The skin serves as the primary physical barrier and plays a critical role in the aesthetic appearance, particularly through its pigmentation and texture. Collagenprash and Collagen builder are developed to support skin integrity by promoting collagen-associated protein expression. This study systematically evaluated these claims through a variety of biochemical and cellular assays. The… Read on PubMed →
The history, development and current status of isotretinoin: a review article.
Clinical and experimental dermatology · 2026
Isotretinoin, a potent retinoid, is highly effective in the treatment of severe acne vulgaris. Its nearly 60-year history began with the Swiss pharmaceutical company La Roche in the 1960s, where it was initially studied for potential benefits in cancer treatment. This article delineates the historical trajectory of isotretinoin from early clinical trials in the 1970s and 1980s, highlighting its… Read on PubMed →
Climate, Humidity, and Population-Level Interest in Dry Skin: Infodemiology Analysis Using Google Trends Across the United States.
JMIR dermatology · 2026
BACKGROUND: Climate and weather factors of temperature and humidity are widely reported to be associated with xerosis (dry skin), a common inflammatory skin condition and frequent driver of pruritus (itchy skin) and reduced quality of life. Growing evidence supports links between environmental conditions and skin barrier function, with extreme climates associated with increased atopic… Read on PubMed →