Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
374 papers
A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women.
Nutrients · 2026
BACKGROUND: Centella asiatica has been widely recognized for its dermatological benefits; however, clinical evidence supporting the efficacy of oral supplementation for improving skin aging parameters remains limited. This randomized, double-blind, placebo-controlled study evaluated the effects of oral Centella asiatica extract on skin wrinkles and related skin parameters in middle-aged… Read on PubMed →
Living Probiotic Microneedles Coordinate Antiandrogen and Nitric Oxide Therapy for Androgenetic Alopecia.
ACS applied materials & interfaces · 2026
Androgenetic alopecia (AGA) is characterized by follicular miniaturization mediated by androgens along with chronic inflammatory and vascular disturbances. These alterations suggest broader dysregulation involving endocrine pathways, immune activity, and vascular function. Current therapies such as finasteride and minoxidil provide limited and often transient improvement because they target only… Read on PubMed →
Knufia epidermidis Infection: A Case Report and Literature Review.
The American journal of tropical medicine and hygiene · 2026
A 16-year-old male patient was admitted to the study hospital with a 6-month history of two itchy, round, xerotic lesions affecting the skin on his wrists. A definite diagnosis was not made in the local hospital, and antibiotics were administered without improvement. Using mycological culture and intergenic transcriptional space sequencing, the patient was diagnosed with a Knufia epidermidis (K… Read on PubMed →
Enhanced corneal retention of hyaluronic acid via a metabolic glycoengineering-based in vivo bioorthogonal reaction.
Biomaterials science · 2026
Topical hyaluronic acid (HA) formulations have been extensively employed for managing various ocular diseases, but their therapeutic efficacy is severely compromised by rapid precorneal clearance due to a dense, negatively charged sialic acid-rich glycocalyx. To address this, we report a corneal surface engineering strategy that involves the metabolic incorporation of bioorthogonal azide groups… Read on PubMed →
Sunscreen and UV filters: a comprehensive review of formulation, safety, and efficacy.
International journal of pharmaceutics · 2026
Photoprotection remains a critical global public health need, yet the current generation of sunscreens faces challenges related to toxicological safety, efficacy, and environmental impact. This review provides an analysis of the development of ultraviolet (UV) filters, integrating photochemistry, new formulation strategies, toxicological risks, and the regulatory landscape. The mechanisms of… Read on PubMed →
Silk Sericin Functionalized with Carboxy Drugs for Dermocosmetic Applications.
ACS applied bio materials · 2026
Silk sericin protein, a textile industry by-product showing no toxicity on oral/topical administration, has recently been exploited as a drug delivery system. The high serine content in sericin makes its functionalization through covalent ester-type bonds feasible; however, only in a few cases have covalent conjugates of sericin with the drug to be delivered been developed. In this paper, we… Read on PubMed →
Geographic and population disparities in cutaneous melanoma in the United States: state-level trends and national population-level analyses.
BMC public health · 2026
BACKGROUND: Over recent decades, cutaneous melanoma (CM) incidence in the United States (US) has increased but now appears to be plateauing, whereas mortality has declined. However, much less is known about how CM incidence and mortality vary between states, or about how differences between states in incidence relate to lifestyle factors, ambient UV exposure, and prevention or health care… Read on PubMed →
Comparative Efficacy of Topical Chitosan and Minoxidil in Hair Loss: A Controlled Study With Microneedling.
The Journal of craniofacial surgery · 2026
BACKGROUND: Chitosan, a natural polysaccharide with immunomodulatory and regenerative properties, has shown promise in enhancing tissue repair. While 5% minoxidil remains the standard treatment for androgenetic alopecia, interest in non-hormonal or adjunctive therapies such as chitosan is growing. OBJECTIVE: To evaluate the clinical efficacy and safety of topical 2% chitosan applied after… Read on PubMed →
Transient p53/p21 activation selectively protects healthy human hair follicles and their stem cells from chemotherapy.
The Journal of clinical investigation · 2026
Chemotherapy-induced alopecia (CIA) remains one of the most distressing adverse effects of cancer therapy. Yet, no therapy is available to selectively protect healthy hair follicles (HFs) and their epithelial stem cells (eHFSCs) from chemotherapy-induced damage without awarding potential survival benefits to cancer cells. Here, we report how human HFs can be protected against 2 lead CIA-inducing… Read on PubMed →
Mandelamide Isolated from Prunus persica Flowers Attenuates TNF-α-Driven Oxidative and Inflammatory Responses in Human Skin Cells.
Biomolecules · 2026
Skin aging is driven by both intrinsic and extrinsic factors, including ultraviolet (UV) radiation and environmental stressors. Tumor necrosis factor-alpha (TNF-α) is a key pro-aging cytokine that promotes reactive oxygen species (ROS) production, leading to collagen degradation and inflammatory responses in skin cells. In this study, we investigated the protective effects of Prunus persica flower… Read on PubMed →
Advances in Gentle Polymeric Cleansing Technologies.
Journal of drugs in dermatology : JDD · 2026
Modern skin cleansers have evolved from basic soaps to advanced cleansing formulations that also provide moisturization and skin barrier support. Surfactants work by emulsifying oils and reducing surface tension, but they may disrupt essential lipids in the skin, leading to barrier damage and sensitivity. Advances in surfactant technology have enabled the development of cleansers that combine… Read on PubMed →
Radiation-Induced Side Effects to the Skin Due to 177 Lu-PSMA Extravasation : A Case Report.
Clinical nuclear medicine · 2026
We report a case with clinical side effects related to extravasation of 177 Lu-PSMA (estimated activity of 2.25 GBq) after administration via the cubital vein. After initial cooling (±10 min), the patient was asked to elevate and mobilize the arm. Five weeks post-injection (p.i.), the patient reported localized pruritus. An erythematosqualous plaque with lichenification was observed. At 9 weeks… Read on PubMed →
Efficacy and Safety of Topical Metformin vs Kligman Formula in the Treatment of Melasma: A Split-Face Study.
Journal of drugs in dermatology : JDD · 2026
BACKGROUND: Melasma is an acquired pigmentary disorder characterized by symmetrical hyperpigmented macules and patches on sun-exposed areas, primarily the face. Kligman's formula, or "triple combination cream," is widely used but has potential side effects. Metformin, an oral anti-diabetic agent, possesses anti-inflammatory and anti-oxidative properties, suggesting its possible role in melasma… Read on PubMed →
Safety and Efficacy of Aminolevulinic Acid 20% Topical Solution Activated by Blue Light for Facial Cutaneous Squamous Cell Carcinoma in situ.
Journal of drugs in dermatology : JDD · 2026
BACKGROUND: Squamous cell carcinoma in situ (isSCC) is an early-stage cutaneous malignancy that requires effective treatment to prevent progression to invasive SCC. Aminolevulinic acid photodynamic therapy (ALA-PDT) is a noninvasive treatment that selectively targets neoplastic cells. This study evaluated the effectiveness, safety, and tolerability of ALA-PDT for the treatment of patients with… Read on PubMed →
Associations between Perceived Costs and Rewards of Sun Protection and Sun Safety Practices among Rural and Urban High School Students.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
BACKGROUND: Adolescents frequently engage in behaviors that increase ultraviolet radiation (UVR) exposure, elevating their lifetime risk for skin cancer. This study examined cross-sectional associations between high school students' perceptions of the costs of UVR protection, the rewards of tanning, and their engagement in UVR-protective behaviors to identify targets for intervention. METHODS… Read on PubMed →
Iron Oxides in Tinted Sunscreen for Hyperpigmentation: A Product Analysis and Literature Review.
Journal of drugs in dermatology : JDD · 2026
BACKGROUND: Hyperpigmentation disproportionately affects skin of color, often exacerbated by visible light (VL) exposure. Photoprotection in these populations remains underused due to the cosmetic incompatibility of sunscreens and the lack of targeted education. Iron oxides have emerged as essential VL blockers in tinted sunscreens for hyperpigmentation management. OBJECTIVES: To evaluate the… Read on PubMed →
Effectiveness of a Nurse-Led, WhatsApp-Based, Interactive Educational Intervention on Skin Cancer Knowledge and Sun Protection Behaviors: A Randomized, Controlled, Solomon Four-Group Study.
Asian Pacific journal of cancer prevention : APJCP · 2026
OBJECTIVE: This study aimed to examine the effectiveness of an interactive educational intervention delivered via WhatsApp on improving community-dwelling women 's knowledge of skin cancer and sun protection behaviors. The study was conducted using a randomized, controlled experimental design based on the Solomon four-group model. METHODS: A randomized, controlled trial was conducted with 152… Read on PubMed →
Topical Vitamin C in the Prevention and Treatment of Actinic Keratoses and Nonmelanoma Skin Cancers: A Systematic Scoping Review.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2026
BACKGROUND: Vitamin C is an antioxidant that is involved in collagen synthesis, maintenance of the skin barrier, and neutralization of free oxygen radicals in the skin. The potential for use of topical vitamin C as a therapeutic and protective agent against actinic keratoses (AKs) and skin cancers has not been fully delineated. OBJECTIVE: To review the current evidence on topical vitamin C in the… Read on PubMed →
Vitamin A: Biological Functions and Implications for Muscle Health.
Nutrition reviews · 2026
Skeletal muscle diseases represent a diverse group of conditions, often characterized by muscle weakness, atrophy, and functional impairment. These disorders continue to impose a significant burden on global health, affecting millions of individuals worldwide. As the prevalence of muscle-related diseases rises, it becomes increasingly important to understand the complex biological mechanisms that… Read on PubMed →
Treatment of Confluent and Reticulated Papillomatosis Using Fixed-Dose Clindamycin phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel.
Journal of drugs in dermatology : JDD · 2026
INTRODUCTION: Confluent and reticulated papillomatosis (CARP) is a rare, non-systemic disease usually treated using oral antibiotics. CASE PRESENTATION: We present a 15-year-old male with CARP for whom initial treatment with doxycycline, ketoconazole shampoo, and topical minocycline was ineffective. He was subsequently treated with a combination of fixed-dose triple-combination clindamycin… Read on PubMed →