Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
130 papers under Contact allergy
Mapping of Former Strategies and Future Needs for Regulatory Prevention of Skin Sensitization: Cosmetic Products.
Contact dermatitis · 2026
Contact allergy related to use of cosmetic products remains a considerable problem in the European Union population. The objectives of this study were to identify pitfalls in EU risk assessment methodologies and regulation(s) for cosmetic products and identify areas of potential improvements in future regulatory strategies. Two significant contact allergens, methylisothiazolinone and… Read on PubMed →
An Unexpected Culprit: Allergic Contact Dermatitis Caused by Benzyl Alcohol in Moist Toilet Paper.
Contact dermatitis · 2026
Fragrance and Preservative Contact Allergens in Cosmetic and Household Cleaning Products in Turkey: Variation by Target Population, Product Type and Manufacturing Origin.
Contact dermatitis · 2026
<h4>Background</h4>Fragrance and preservative chemicals in cosmetic and household cleaning products are recognised causes of allergic contact dermatitis.<h4>Objectives</h4>To identify fragrance and preservative ingredients with potential contact allergenicity in Turkish market products.<h4>Methods</h4>Labels of 245 products, including predominantly rinse-off cosmetic products and household… Read on PubMed →
Determination of Rosin Oxidation Products in Pigments and Inks as a Potential Source of Tattoo Allergenicity.
Contact dermatitis · 2026
BACKGROUND: The vast majority of allergic tattoo reactions involve red-shaded tattoos without a causal explanation. OBJECTIVE: To determine rosin oxidation products (ROPs) in pigments and tattoo inks as a hypothesised source of tattoo allergenicity. MATERIALS AND METHODS: Content of pigment samples (n = 112) and tattoo inks (n = 119) was analysed using newly developed UHPLC/PDA/MS methods, XRD… Read on PubMed →
Contact Allergy to Ingredients of Hair Cosmetics Associated with Occupational and Non-Occupational Exposure-Trends from 1995 to 2020 in Central Europe, with or without Regulation.
Contact dermatitis · 2026
BACKGROUND: Hair cosmetic products contain various chemicals which are partly potent contact sensitizers. These may cause occupational hand eczema in hairdressers, but also scalp and face dermatitis in consumers. OBJECTIVE: To (i) highlight differences between the spectrum of occupational and non-occupational exposure reflected in sensitization, and (ii) correlate trends in the last decades with… Read on PubMed →
Advances in the application of computational toxicology in cosmetic safety assessment.
Archives of toxicology · 2026
With the global ban on animal testing for cosmetics, computational toxicology has emerged as a pivotal alternative for safety assessment. This review systematically analyzes technical frameworks, literature trends, multi-endpoint applications, and global regulatory developments. The study integrates core in silico methods, including quantitative structure–activity relationship (QSAR) models… Read on PubMed →
Update to RIFM fragrance ingredient safety assessment, 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized, CAS Registry Number 73018-51-6.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2026
1,6-Octadien-3-ol, 3,7-dimethyl-, acid-isomerized was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data show that 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized is not genotoxic. Data on 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized provide a calculated… Read on PubMed →
Isothiazolinones in Disposable Rubber Gloves-Results of Chemical Analysis.
Contact dermatitis · 2026
BACKGROUND: Contact allergy to benzisothiazolinone (BIT) has increased in recent years, but exposure to it is not always found. It's important to know whether the gloves might be an isothiazolinone source especially in patients with symptoms from gloves and isothiazolinone contact allergy with or without allergy to rubber chemicals. OBJECTIVES: To present results of chemical analysis of… Read on PubMed →
Solid Shampoo Is Mostly Not Preserved, in Contrast to Liquid Shampoos Used in Hairdressing-A Market Survey in Four European Countries.
Contact dermatitis · 2026
BACKGROUND: Hairdressers are frequently exposed to shampoos, both from neat liquid products and dilutions, often with unprotected hands. Shampoos usually contain preservatives. While the level of preservation is guided by risk assessment based on typical consumer exposure, this will underestimate sensitization risk in hairdressers. Lower exposure or avoidance of preservative-containing hair… Read on PubMed →
Update to RIFM fragrance ingredient safety assessment, isopropylphenylbutanal, CAS Registry Number 125109-85-5.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2026
The existing information supports the use of this material as described in this safety assessment. Isopropylphenylbutanal was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Target data show that isopropylphenylbutanal is not genotoxic and provide a calculated… Read on PubMed →
Allergic Contact Dermatitis of the Hands: A Retrospective Cohort Study From Turkey Between 1996 and 2021.
Contact dermatitis · 2026
BACKGROUND: Allergic contact dermatitis (ACD) is a rare but significant cause of hand eczema (HE). OBJECTIVES: To evaluate positive patch test reactions in HE patients, focusing on frequency, clinical/occupational relevance and sources of exposure at a tertiary referral centre in Turkey. METHODS: Retrospective analysis of 1499 HE patients from 2533 consecutively patch-tested individuals… Read on PubMed →
Update to RIFM fragrance ingredient safety assessment, (Z)-2-penten-1-ol, CAS Registry Number 1576-95-0.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2026
(Z)-2-Penten-1-ol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analogs 2,6-nonadien-1-ol (CAS # 7786-44-9) and trans-2-hexenol (CAS # 928-95-0) show that (Z)-2-penten-1-ol is not expected to be genotoxic. Data on read-across analog… Read on PubMed →
Homemade toothpastes: what recipes for what effects?
British dental journal · 2026
Introduction Nowadays, mistrust of industrial products has led to the growing popularity for homemade (or do-it-yourself [DIY]) products, specifically in the field of cosmetics and hygiene products such as toothpastes.Aims The aim of the present work was to complete the data collection by systematically reviewing DIY toothpaste (DIYT) recipes found online and gather information on composition… Read on PubMed →
Update to RIFM fragrance ingredient safety assessment, naphtho[2,1-b]furan, dodecahydro-3a,6,6,9a-tetramethyl-, (3aR,5aS,9aS,9bR)-, CAS Registry Number 6790-58-5.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2026
Naphtho[2,1-b]furan, dodecahydro-3a,6,6,9a-tetramethyl-, (3aR,5aS,9aS,9bR)- was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data show that naphtho[2,1-b]furan, dodecahydro-3a,6,6,9a-tetramethyl-, (3aR,5aS,9aS,9bR)- is not genotoxic, provide a calculated… Read on PubMed →
Contact Sensitization in Adults With Atopic Dermatitis: A 21-Year Single-Center Tertiary Experience.
Contact dermatitis · 2026
BACKGROUND: Atopic dermatitis is a common chronic inflammatory skin condition. Data on contact sensitization in adults with atopic dermatitis remain limited. OBJECTIVES: To investigate the prevalence of contact sensitization in adults with and without AD: PATIENTS/METHODS: A monocentric, retrospective study analysed 8967 adults (≥ 16 years) patch-tested at the University of Padua (1997-2018)… Read on PubMed →
Kitasamycin overcomes ferroptosis and immunotherapy resistance by targeting the HUWE1-NCOA4-FTH1 axis.
Autophagy · 2026
Clinicians typically avoid antibiotics use during immunotherapy due to concerns about reduced efficacy. However, cancer patients requiring antibiotics postoperatively or for infections urgently need options that provide antimicrobial coverage while potentially enhancing, rather than impairing, immunotherapy. Restoring ferroptosis susceptibility represents a promising strategy to overcome… Read on PubMed →
Acrylate Allergic Contact Dermatitis Among Manicure Consumers and Professionals.
Nursing for women's health · 2026
Acrylate allergic contact dermatitis is a growing concern, particularly among women exposed to nail cosmetics as consumers or professionals. Not all nail products carry equal risk. Repeated exposure to acrylates or improper curing can lead to symptoms resembling other forms of allergic contact dermatitis. Onycholysis is one common symptom that can be painful and slow to heal. Treatment of acrylate… Read on PubMed →
Co-Reactivity of Fragrances and Fragrance-Markers in Patients With Positive Patch Tests to Chinese and Brazilian Propolis.
Contact dermatitis · 2026
BACKGROUND: In patients with contact allergy to Chinese propolis, co-reactivity to the four fragrance markers present in the European baseline series ( Myroxylon pereirae resin [balsam of Peru], colophonium, fragrance mixes 1 and 2) has been well documented. The co-reactivity pattern of Brazilian propolis has not yet been sufficiently analysed. OBJECTIVES: To investigate co-reactivity patterns to… Read on PubMed →
HER2-dependent paraptosis and ferroptosis induction by cannabidiol in breast cancer cells.
Biochimica et biophysica acta. Molecular basis of disease · 2026
HER2 (human epidermal growth factor receptor 2) is a well-established oncogenic driver and therapeutic target in breast cancer. Cannabidiol (CBD), a non-psychoactive phytocannabinoid, has demonstrated anticancer potential, yet its mechanisms of action in HER2-positive breast cancer remain insufficiently characterized. In this study, we examined the effects of CBD on HER2-positive (SK-BR-3, BT-474)… Read on PubMed →
Assessing the skin sensitization potential of fragrance ingredients in consumer products using the peroxidase peptide reactivity assay (PPRA) as an additional weight of evidence.
Toxicology in vitro : an international journal published in association with BIBRA · 2026
A fragrance ingredient's potential to induce skin sensitization is an important factor in risk assessment. The key events in the skin sensitization adverse outcome pathway (AOP) can be evaluated with new approach methodologies (NAMs) for hazard identification, potency, and point of departure (PoD) derivation, distinguishing between sensitizers and non-sensitizers. The first key event is the… Read on PubMed →