Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
374 papers
Multifunctional Hyaluronic Acid Releasing Hydrogel Film With Nano/Micro Wrinkles: Thin Acne Patch for Localized Therapeutics.
Macromolecular bioscience · 2026
Hyaluronic acid (HA) is effective in reducing skin inflammation and sebum production in acne vulgaris. Localized treatment with HA involves rapid dissolving microneedle-based formulations to penetrate and release active ingredients. These causes discomfort and secondary wounds, which eventually aggravate inflammatory responses, thereby increasing the risk of scaring and pathogenesis. This study… Read on PubMed →
Acne Laser Devices in Dermatology.
Dermatologic clinics · 2026
Laser and energy-based devices play an expanding role in acne management by targeting sebaceous hyperactivity, vascular inflammation, and microbial colonization. While light-based systems provide modest benefit in mild disease, thermal near-infrared lasers offer indirect sebaceous suppression. Lipid-selective 1726 nm technology represents a biologically aligned advancement with promising clinical… Read on PubMed →
Comparative efficacy, recovery, and pigmentary safety of radiofrequency microneedling and fractional carbon dioxide laser for facial atrophic acne scars: a prospective randomized split-face trial.
The Journal of dermatological treatment · 2026
OBJECTIVE: To compare efficacy, recovery, pigmentary safety, and patient-reported outcomes of radiofrequency microneedling (RFMN) and fractional carbon dioxide laser (FCO2) for facial atrophic acne scars. METHODS: In this prospective, randomized, split-face, evaluator-blinded exploratory trial, 33 patients were enrolled, and 30 completed the study. Each facial side was assigned to RFMN or FCO2… Read on PubMed →
Icariin Regulates Acne Pathophysiology and Extracellular Matrix Protein Synthesis: Implications for Acne Vulgaris and Atrophic Acne Scar Management.
Experimental dermatology · 2026
Icariin, the principal active compound of Epimedium species used in traditional East Asian medicine, exhibits anti-inflammatory and lipid-regulating effects. However, its effects on human sebocytes and dermal fibroblasts, which could be implicated in the management of acne and atrophic scarring, remain unexplored. This study aimed to evaluate the effects of icariin on human sebocytes… Read on PubMed →
Severe cutaneous adverse reactions associated with systemic antibiotics in acne vulgaris: a systematic review.
The Journal of dermatological treatment · 2026
BACKGROUND: Acne vulgaris (AV) is an inflammatory disorder of the pilosebaceous unit commonly managed with systemic antibiotics. Since antibiotics are known triggers of severe cutaneous adverse drug reaction (SCARs), patients with AV receiving prolonged antibiotics are at potential risk. This study aims to describe reported cases of SCARs occurring among AV patients treated with systemic… Read on PubMed →
Development and Validation of a Novel Plasma Metabolomic Signature for the Detection of Renal Cell Carcinoma.
European urology · 2026
BACKGROUND AND OBJECTIVE: Early diagnosis is critical for improving survival in renal cell carcinoma (RCC); yet, effective laboratory tests remain lacking. We aimed to characterise metabolic reprogramming in RCC and develop an artificial intelligence (AI)-enabled plasma metabolic model for RCC detection. METHODS: In this multicentre diagnostic model development and validation study, plasma… Read on PubMed →
Topical PEGylated azelaic acid nanohybrids: A lipid-polymer hydrogel system for sustained dermal delivery in rosacea management.
Colloids and surfaces. B, Biointerfaces · 2026
Rosacea is a chronic inflammatory disorder of the central face characterized by persistent erythema, flushing, and inflammatory papules. Azelaic acid (Az) is a first-line topical therapy for papulopustular rosacea; however, its clinical efficacy is limited by poor aqueous solubility and restricted penetration across the stratum corneum. To overcome these limitations, PEGylated lipid-polymer hybrid… Read on PubMed →
Closing the Gap in Photoprotection: Implications for Skin of Colour in Australia.
The Australasian journal of dermatology · 2026
Long wave UVA1 is a critical driver of hyperpigmentation and skin aging in skin of colour. In combination with visible light, it shares a synergistic relationship in amplifying oxidative damage and hyperpigmentation in skin of colour. Disorders of hyperpigmentation affect a large proportion of Australians and have significant psychosocial burden. Photoprotection remains the mainstay of treatment… Read on PubMed →
The cutaneous microbiome as a dynamic photoprotective interface against solar radiation.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
This review reframes cutaneous photoprotection as a host–microbe system and synthesizes evidence, largely from experimental model systems and human observational studies, that resident skin microbes sense, transform, and defend against solar ultraviolet stress. We introduce the “host-protective UV-resistome” defined as the subset of microbial genes and pathways that confer photoprotection to the… Read on PubMed →
Skin Cancer Prevention in Agricultural Workers: A Review of Sun Safety Practices and Intervention Strategies (2013-2024).
Journal of agromedicine · 2026
OBJECTIVE: Agricultural workers face significantly higher ultraviolet radiation (UVR) exposure than indoor workers, increasing their skin cancer risk. This systematic review evaluates peer-reviewed literature from 2013 to 2024 on sun safety behaviors and interventions among agricultural workers. METHODS: Following PRISMA guidelines, a search was conducted across PubMed, SCOPUS, Cochrane Library… Read on PubMed →
Prevalence and correlates of clinical skin checks for skin cancer among Australians.
Cancer epidemiology · 2026
BACKGROUND: In Australia, early detection of melanoma relies on opportunistic skin checks, yet information on skin check behaviours in the general population is limited. We aimed to examine the prevalence and correlates of clinical skin checks in a large Australian cohort. METHODS: The 45 and Up Study recruited 267,357 New South Wales residents between 2005 and 2009. We assessed self-reported… Read on PubMed →
Subcellular photoprotection through precision nutraceuticals: Divergent actions of rutin and punicalagin on redox and mitochondrial homeostasis in human dermal fibroblasts.
Journal of photochemistry and photobiology. B, Biology · 2026
Excessive ultraviolet A (UVA) exposure is a major environmental factor contributing to skin photoaging and oxidative damage. Identifying natural compounds that can counteract these effects is increasingly relevant for preventive and personalized healthcare. Precision nutrition uses diet-derived bioactives to modulate molecular pathways in defined cellular contexts. Polyphenols are promising for… Read on PubMed →
Sunscreen and vitamin D: Part I.
Clinics in dermatology · 2026
It is so ubiquitous in our medicine drawers, as a supplement and as a therapy, that we hardly give a thought to the process of its discovery. It feels as if we have always had vitamin D. Our early ancestors were thought to have had darkly pigmented skin and to have migrated out of Africa some 70,000 to 60,000 years ago. With their migration, they evolved to have lighter skin, thereby losing some… Read on PubMed →
Sunscreen and Vitamin D. Part II: Sunscreen, SPF and Impact on Vitamin D.
Clinics in dermatology · 2026
Sunscreens were available in ancient societies, such as Egypt, Greece, Arabia, and Japan, often to help keep the skin lighter and more fashionable. With the promotion of a tan as a sign of a leisurely, privileged lifestyle came the discovery of the harmful effects of sunlight on the skin. These include skin cancer, discovered by Unna and experimentally confirmed by Findlay, which paved the way for… Read on PubMed →
TiO2 nanoparticle-embedded starch-tannin biocomposites with efficient UV-shielding and ROS elimination as Pickering emulsifier for bio-safe sunscreen.
International journal of biological macromolecules · 2026
Inorganic nanoparticles with excellent anti-ultraviolet ability such as titanium dioxide (TiO2) are extensively utilized in sunscreens to protect against UV-induced skin photodamage and carcinogenesis. However, conventional TiO2 nanoparticles exhibit inherent photocatalytic activity that generates harmful reactive oxygen species (ROS), which limits their applications as sunscreen. In this work, we… Read on PubMed →
In Vivo Measurement of UVA Protection Factor (ISO 24442:2011) Across 38 Different SPF 50 and SPF 50+ Sunscreens Reveals High Heterogeneity and Limitations in the Level of Protection.
Photodermatology, photoimmunology & photomedicine · 2026
BACKGROUND/PURPOSE: The UVB and UVA components of terrestrial solar ultraviolet radiation (UVR) cause acute and chronic damage to skin. These adverse effects can be reduced by sunscreen application. The sun protection factor (SPF) is primarily a measure of UVB protection against erythema and does not quantify protection from UVA, which is the major component of solar UVR. The study aim was to… Read on PubMed →
Broad-spectrum abnormal localized photosensitivity syndrome: a case report and literature review.
Photodiagnosis and photodynamic therapy · 2026
Broad-spectrum abnormal localized photosensitivity syndrome (BALPS) is a rare photodermatosis characterized by recurrent cutaneous eruptions occurring at fixed body sites following ultraviolet (UV) radiation exposure. This report presents a case of skin phototype III in a 30-year-old woman who presented with a 7-year history of recurrent erythematous to violaceous, edematous plaques occurring… Read on PubMed →
Sunscreen Efficacy Against UVA1- And Visible Light-Induced Skin Pigmentation Is Influenced by Ancestry.
Photodermatology, photoimmunology & photomedicine · 2026
BACKGROUND: There is growing evidence that individuals with different skin phototypes require tailored approaches to achieve optimal photoprotection. Individuals with darker skin phototypes are more prone to UVA1- and visible light-induced pigmentation, whereas lighter phototypes are more susceptible to shorter wavelengths such as UVB and UVA2. Thus, skin phototype is an important determinant of… Read on PubMed →
Histopathological evaluation of facial melasma treated with oral tranexamic acid alone and in combination with ketotifen.
Anais brasileiros de dermatologia · 2026
BACKGROUND: Tranexamic Acid (TA) has demonstrated effectiveness on melasma treatment, and Ketotifen (KET) may inhibit mast cell-mediated melanogenesis. The histologic basis of their depigmenting effects remains unclear. OBJECTIVES: To evaluate histopathological changes from TA with KET over a 3-month treatment. METHODS: In this randomized, double-blind trial, 50 women with facial melasma were… Read on PubMed →
Game theory and environmental health behavior: a population model of sunscreen use, social norms, and melanoma incidence.
Frontiers in public health · 2026
INTRODUCTION: Melanoma is a largely preventable yet economically significant cancer, particularly in high-UV regions. Despite strong evidence that sunscreen reduces melanoma risk, its use remains suboptimal due to misaligned private and social incentives. METHODS: We develop an evolutionary game-theoretic model in which individuals choose between sunscreen use and non-use. Payoffs incorporate… Read on PubMed →