Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
374 papers
Multi-metric health risk assessment of heavy metal contamination in cosmetics: A comparative analysis of makeup, henna and skin creams.
Regulatory toxicology and pharmacology : RTP · 2026
This study quantified thirteen metal impurities in 113 cosmetic products using validated ICP-MS. Widespread contamination was observed, with 50.4% of samples exceeding international limits. The highest concentrations occurred in pigment-rich products: cadmium reached 3052 mg/kg in blusher, lead 131 mg/kg in face powder, and chromium 11145 mg/kg in black henna. Risk assessment indicated safety… Read on PubMed →
The Role of AhR in Skin Photobiology: Yin-Yang Effects.
Experimental dermatology · 2026
Ultraviolet radiation (UVR) elicits complex, context‑dependent responses in the skin that reflect the balance between environmental stress and adaptive homeostatic mechanisms. The aryl hydrocarbon receptor (AhR) occupies a central position in this interface, acting as a tunable environmental sensor that can mediate both photodamage and photoprotection depending on ligand type, timing and cellular… Read on PubMed →
Unlocking the skin protection potential of discarded Dictyophora rubrovalvata volva: Structural, rheology and anti-photoaging insights into its unique polysaccharides.
International journal of biological macromolecules · 2026
Dictyophora rubrovalvata is a valuable edible fungus, while research on its bioactive components has primarily focused on the fruiting body, other parts, notably the discarded volva colloid, remain underexplored. In order to explore the skin protection of polysaccharides from volva colloid, herein, polysaccharides from the fruiting body (IP), pileus (FP), and volva colloid (VP) were extracted… Read on PubMed →
A Randomized, Double-Blinded Pilot Study Comparing Synthetic Versus Human-Derived Topical Epidermal Growth Factor for Facial Rejuvenation and Psychosocial Perception.
Journal of cosmetic dermatology · 2026
BACKGROUND: Topical growth factor-containing cosmeceuticals are widely used to improve visible signs of facial photoaging. Interest has increased in peptide-based alternatives that aim to support similar regenerative pathways without relying on human-derived biologics. AIM: To compare the clinical efficacy, tolerability, and exploratory psychosocial perception outcomes of a topical recombinant… Read on PubMed →
Integrated photoprotection and senescence modulation: A topical formulation counteracts cellular aging in human skin cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026
BACKGROUND: Skin aging is driven by the accumulation of senescent cells that release a pro-inflammatory mediators, which collectively disrupt tissue homeostasis. Beside ultraviolet A (UVA) and ultraviolet B (UVB) radiation, high-energy visible blue-violet (HEV) light contributes to oxidative stress, mitochondrial dysfunction and premature keratinocyte senescence. A novel photoprotective topical… Read on PubMed →
From Ultraviolet to Visible Light: Emerging Concepts in Comprehensive Photoprotection.
Photodermatology, photoimmunology & photomedicine · 2026
BACKGROUND: Photoprotection has traditionally focused on ultraviolet (UV) radiation, particularly UVB and UVA. Recent evidence highlights the significant role of long-wavelength UVA1 (LW-UVA1, 370-400 nm) and visible light (VL; 400-700 nm) in inducing pigmentation, erythema, and photoaging. This review study summarizes recent advances in LW-UVA1 and VL photoprotection and discusses emerging… Read on PubMed →
Sauchinone attenuates UVB-induced photoaging by suppressing oxidative stress and ferroptosis through activation of the Keap1-Nrf2 pathway in dermal fibroblasts.
Pharmaceutical biology · 2026
CONTEXT: Skin photoaging induced by chronic ultraviolet B (UVB) exposure is primarily driven by oxidative stress. Emerging evidence suggests that ferroptosis contributes to UVB-induced skin damage. Sauchinone, a phenolic lignan derived from Saururus chinensis, possesses potent antioxidant and anti-inflammatory properties; however, its protective effects and underlying mechanisms against… Read on PubMed →
Biomimetic asymmetric Bletilla striata polysaccharide hydrogel with wet adhesion and antibacterial activity for active-passive treatment of infected wound.
International journal of biological macromolecules · 2026
Developing biomimetic asymmetric wound dressings that mimic the structure and multifunctionality of natural skin remains challenging. Here, we report a natural polysaccharide-based asymmetric hydrogel (MP/AMBGZ) derived from Bletilla striata polysaccharide (BSP) via a facile one-pot, two-step strategy. Methacrylated BSP forms a biocompatible network, while gallic acid provides wet adhesion and… Read on PubMed →
Skin-cancer screening preferences and trust in clinicians among outdoor enthusiasts: preference for specialist-led checks.
PeerJ · 2026
INTRODUCTION: Australian outdoor enthusiasts are at heightened risk of skin cancer due to high levels of ultraviolet (UV) exposure. Regular screening is essential for early detection; little is known about how trust in clinician expertise and screening frequency shape behaviors in this cohort . METHODS: A cross-sectional survey of 1,403 adult outdoor enthusiasts attending a skin cancer clinic… Read on PubMed →
Enhancing Photoprotection: Assessing Visible Light Photoprotection in Tinted Inorganic Sunscreens.
Photodermatology, photoimmunology & photomedicine · 2026
BACKGROUND: Visible light (VL, 400-700 nm) and long wavelength UVA1 (VL + UVA1, 370-700 nm) have been reported to cause erythema in light skin phototypes, Fitzpatrick skin types I-III (FST I-III), and to exacerbate pigmentary dermatologic conditions (e.g., melasma, hyperpigmentation, post-inflammatory hyperpigmentation) in individuals with dark skin phototypes (FST IV-VI). Until recently, limited… Read on PubMed →
Development and validation of a skin health knowledge, attitudes, and behaviors questionnaire for the general population: a cross-sectional study.
Frontiers in public health · 2026
BACKGROUND: Existing skin health assessments predominantly focus on single topics or diseases, making it difficult to cover the complete "Knowledge-Self-efficacy-Attitudes-Behaviors (KSAB)" continuum. OBJECTIVE: To develop and validate a skin health knowledge, attitudes, and behaviors questionnaire for the general population. METHODS: A cross-sectional online survey was conducted among the… Read on PubMed →
A curriculum-integrated sun safety intervention to improve adolescent skin health knowledge in an independent girls' secondary school.
PloS one · 2026
Australia has one of the world's highest melanoma incidences among youth. Adolescents often under-prioritise sun protection due to sociocultural factors, for example, the perceived attractiveness of tanned skin and a sense of invulnerability. This study reports on a curriculum-integrated sun safety intervention implemented in a single independent girls' secondary school, a context that provides… Read on PubMed →
The heterogeneity of dermal mesenchymal cells reproduced in skin equivalents regulates barrier function and elasticity.
EMBO reports · 2026
The heterogeneity of dermal mesenchymal cells, including perivascular mesenchymal cells and papillary and reticular fibroblasts, plays critical roles in skin homeostasis. Herein, we present human skin equivalents (HSEs), in which pericytes, papillary fibroblasts, and reticular fibroblasts are spatially organized through autonomous three-cell interactions among epidermal keratinocytes, dermal… Read on PubMed →
Skin cancer and vitamins: In theory and practice.
Clinics in dermatology · 2026
Skin cancers are common malignant tumors with an increasing incidence worldwide. The major types are cutaneous malignant melanoma and keratinocytic tumors, such as basal cell carcinoma and cutaneous squamous cell carcinoma. The first treatment of choice is complete surgical removal, but nonsurgical treatment options and primary prevention may be requested. Vitamins may play a role in skin cancer… Read on PubMed →
Study on the Multiple Efficacies of Vitamin C Serum in Anti-Glycation, Anti-Carbonylation, Antioxidation, and Anti-Inflammation of Human Skin Based on In Vivo Tests.
Journal of cosmetic dermatology · 2026
BACKGROUND: Skin glycation, oxidation, carbonylation, and excessive inflammation are well-recognized factors contributing to skin aging and pigmentation. Previous in vitro studies have confirmed vitamin C's antioxidant, anti-glycation, and anti-inflammatory properties, but its in vivo effects remain to be further verified. AIMS: To investigate the in vivo effects of topical vitamin C serum on… Read on PubMed →
A Narrative Review of Candidate Biomarkers of Total Fruit and Vegetable Intake.
Nutrition bulletin · 2026
While an abundance of cohort studies has suggested that greater consumption of fruits and vegetables (FVs) is associated with reduced risk of chronic diseases, current self-report based dietary assessment tools are susceptible to biases that can reduce their accuracy in estimating dietary intakes, and consequently, the risk estimates obtained from this research. As a result, considerable attention… Read on PubMed →
Establishing synergistic role of acacia honey and vitamin C: A promising strategy for faster wound tissue regeneration.
Injury · 2026
Being established as an important natural component for wound healing, acacia honey (AH) in combination with ascorbic acid (AA) was evaluated for its tissue regenerative properties to establish a synergistic effect. A thermosensitive hydrogel formulation was developed and characterized for viscosity, mucoadhesion, moisture retention, pH, and morphology, where the parameters were found to be… Read on PubMed →
The study of transdermal delivery mechanism of liposomes using stratum corneum lipid membrane model.
Colloids and surfaces. B, Biointerfaces · 2026
A reliable assessment of skin permeation is essential for the rational design of transdermal formulations which effectively deliver active ingredients. In particular, a skin screening platform capable of evaluating skin permeability and elucidating the penetration mechanisms of skin penetration enhancers (SPEs), such as liposomes, is critical for advancing transdermal delivery systems. Here, we… Read on PubMed →
Changes in ultraviolet a radiation-induced thymidine dimers and erythema after oral nicotinamide or polypodium leucotomos extract in healthy volunteers: a randomized intraindividual trial.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
BACKGROUND: Nicotinamide (NAM) and Polypodium leucotomos extract (PL) have demonstrated photoprotective effects, but their role in preventing UVA-induced DNA damage in humans remains unclear. OBJECTIVE: To evaluate the effects of oral NAM and PL on UVA-induced erythema and thymidine dimer (TT-dimer) formation. METHODS: In this intraindividual trial, 50 healthy volunteers (phototypes I-III) were… Read on PubMed →
Efficacy and Safety of a Topical Nicotinamide Adenine Dinucleotide Skinbooster for the Treatment of Melasma.
Aesthetic plastic surgery · 2026
BACKGROUND: Melasma remains a therapeutically challenging hyperpigmentation disorder due to its high recurrence rate and the limitations of existing topical therapies. Nicotinamide adenine dinucleotide (NAD+) is a fundamental coenzyme critical for mitochondrial bioenergetics, DNA repair, and NAD+-dependent sirtuin-mediated gene regulation. Its systemic decline is implicated in cellular ageing and… Read on PubMed →