Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
374 papers
The Effect of Myrtacine and Celastrol-Enriched Extract on Cutibacterium acnes Extracellular Vesicles.
International journal of dermatology · 2026
BACKGROUND: Commensal bacteria interact with each other and their environment, secreting anti-microbial peptides, bacteriocins, and extracellular vesicles (EVs). Cutibacterium acnes (C. acnes), a commensal bacterium that plays a major role in acne, is classified into different phylotypes (IA1, IA2, IB, IC, II, and III), where overabundance of phylotype IA1 relative to other phylotypes is found in… Read on PubMed →
Revolutionizing Acne Scar Treatment in Indian Skin with Fractional Picosecond Laser.
Photobiomodulation, photomedicine, and laser surgery · 2026
BACKGROUND: Patients of Asian descent with Fitzpatrick skin types III-V who experience facial acne scars are a relatively under-researched demographic in medical literature, with limited studies specifically addressing their unique skin characteristics and treatment responses. Traditional treatments have variable efficacy and risk of complications. A novel technique that has shown potential in… Read on PubMed →
Diosmetin, an active ingredient of Schizonepeta tenuifolia, alleviates acne by regulating inflammation and oxidative stress.
Naunyn-Schmiedeberg's archives of pharmacology · 2026
To elucidate the mechanism of Schizonepeta tenuifolia-Diosmetin in acne treatment using an integrated approach combining network pharmacology, molecular dynamics simulation, and experimental validation. Acne-related expression datasets were acquired from GEO, with differentially expressed genes (DEGs) identified using R. Regulatory patterns were visualized via volcano plots and heatmaps… Read on PubMed →
Placebo response and its influencing factors in acne vulgaris: A model-based meta-analysis.
British journal of clinical pharmacology · 2026
AIMS: The high placebo response in acne clinical trials has slowed down the progress of new drug development. Therefore, this study used a model-based meta-analysis method to quantitatively analyse the placebo response and explore its influencing factors. METHODS: This study included 21 627 subjects from acne-related randomized double-blind placebo-controlled trials. Pharmacodynamic models were… Read on PubMed →
Response to the Commentary on "Efficacy and Safety of Er:Glass versus CO2 Lasers in the Treatment of Atrophic Acne Scars: A Systematic Review and Meta-analysis".
Aesthetic plastic surgery · 2026
This response addresses the commentary by Dr. Moghadam regarding our systematic review and meta-analysis comparing Er:Glass and CO2 lasers for atrophic acne scars. We clarify several methodological considerations to reinforce the validity of our findings. First, while laser parameters across included studies were not identical, they represent standard clinical ranges and were restricted to… Read on PubMed →
Proteoglycan Mimetics-Based Antimicrobial and Anti-Inflammatory Microneedles Restoring Dysregulated Lipid Metabolism and Suppressing Skin Atrophy for Acne Treatment.
Small (Weinheim an der Bergstrasse, Germany) · 2026
Over 15% of acne patients manifest moderate to severe clinical presentations, accompanied with bacterial infection, long-term inflammatory responses, dysregulated lipid metabolism, and post-acne skin atrophy. Although microneedles (MNs) represent an effective transdermal drug delivery system for acne treatment, the therapeutic effects on the restoration of dysregulated lipid metabolism and the… Read on PubMed →
Unlocking the antibacterial potential of Zanthoxylum armatum fruit: A bioactive approach to treat acne vulgaris.
Microbial pathogenesis · 2026
Dermatology has a huge challenge when treating skin infections caused by germs such Cutibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis. Natural bioactive substances originating from plant sources may be employed as therapeutic agents to treat certain disorders is gaining popularity. In this study, we evaluated the potential of bioactive chemicals of Zanthoxylum armatum… Read on PubMed →
What Are the Histological Changes Corresponding to Clinical Effacement of Atrophic Acne Scars After Fractional Carbon Dioxide Laser Intervention-A Prospective Interventional Study in Skin of Color.
Photodermatology, photoimmunology & photomedicine · 2026
BACKGROUND: Pre-defined dose parameters of fractional carbon dioxide (Fr:CO2) laser used for acne scars are not aligned with the histological depth achieved by the laser, which predicts scar improvement. OBJECTIVES: To evaluate the baseline histological depth and architecture of different acne scars and compare the histological changes and clinical improvement after Fr:CO2 laser. METHODS: We… Read on PubMed →
Antimicrobial resistance in commensal skin bacteria among individuals without prior exposure to acne therapy.
Journal of global antimicrobial resistance · 2026
OBJECTIVE: Antimicrobial resistance (AMR) in skin bacteria is a salient issue in patients with acne vulgaris. This study aimed to investigate the AMR status of skin bacteria isolated from university student volunteers with no history of treating acne. METHODS: We evaluated the antimicrobial susceptibility of Staphylococcus epidermidis and Cutibacterium acnes, isolated in 2014 and 2019 from… Read on PubMed →
Chemical identification of the Viola phillipina extracts and their anti-acne activity: A comparison with isotretinoin and salicylic acid.
Fitoterapia · 2026
Since acne is a multifactorial condition, its treatment remains challenging. The multi-target efficacy of plant extracts may be a better way to treat it. In this paper, the components of Viola philippica extracts with different polarity were analyzed by HPLC, and the anti-acne activities were studied from sebum inhibition, anti-inflammatory and bacteriostasis. Results revealed that… Read on PubMed →
An Open Pilot Study of Dual Wave Radiofrequency Microneedling for Acne Scarring in Patients With Skin of Color.
Lasers in surgery and medicine · 2026
OBJECTIVE: This study aimed to evaluate the safety and efficacy of a novel dual-wave radiofrequency microneedling (RFMN) device in treating acne scars and postinflammatory hyperpigmentation (PIH) in patients with Fitzpatrick skin types IV-VI. METHODS: In this unblinded, single-group, prospective pilot study, seven participants over the age of 18 (4 females and 3 males) with mild to severe acne… Read on PubMed →
Effect of α-terpinolene on Propionibacterium acnes-induced hyperkeratosis and inflammation in vitro and in vivo.
Microbial pathogenesis · 2026
Acne can impair patients' appearance and even cause psychological disorders such as anxiety and depression. Given the lipase inhibitory activity of the Pinus massoniana L. needles (PMLN) volatile oil, the present study explores the anti-P. acnes efficacy of the PMLN volatile essential oils and the related molecular mechanisms. Common ingredients in the PMLN volatile oil were screened and their… Read on PubMed →
Multidisciplinary Approach to Complex Lower Extremity Limb Salvage in Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome: A Case Report.
Microsurgery · 2026
Limb salvage using free tissue transfer in patients with rare autoinflammatory syndromes is poorly described, and the safety of microvascular reconstruction in this population remains uncertain. Hereditary pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome is characterized by dysregulated inflammation, pathergy, and impaired wound healing, raising concern for flap compromise and… Read on PubMed →
Phototherapy for Acne Vulgaris: Strategies and Clinical Applications in Sebum Modulation, Inflammation Control, and Scar Management.
Photobiomodulation, photomedicine, and laser surgery · 2026
Background: Acne vulgaris is a chronic inflammatory skin disease, and photo-based therapies have been adopted as noninvasive alternatives to pharmacological treatment.Objective: To systematically evaluate the therapeutic strategies and biological mechanisms of photo-based therapies in the management of acne vulgaris, focusing on sebum modulation, inflammation control, and the treatment of acne… Read on PubMed →
Development and evaluation of a multifunctional natural composite microemulsion for anti-acne therapy: synergistic anti-inflammatory and antibacterial effects.
Drug development and industrial pharmacy · 2026
INTRODUCTION: Acne is a common inflammatory disease of the hair follicles and sebaceous glands, but most of the current treatments have side effects or drug resistance problems. This study developed a stable, self-emulsifying composite Microemulsion (PHS-ME) co-loaded with paeonol, honokiol and Salix alba (white willow) bark extract. METHODS: The formulation was optimized using Box-Behnken… Read on PubMed →
Exploring the Associations Between Mediterranean Diet Adherence and Autoinflammation-Associated Skin Diseases.
Experimental dermatology · 2026
Autoinflammatory diseases (AIDs) are characterized by abnormal responses of the innate immune system, accompanied by elevations in inflammatory biomarkers, in the absence of a physiologic crisis or infection. Certain monogenic AIDs may present with acneiform or hidradenitis suppurativa-like cutaneous manifestations. In contrast, acne vulgaris, plaque psoriasis and hidradenitis suppurativa are… Read on PubMed →
Comparative efficacy and safety of oral azithromycin versus doxycycline in moderate-to-severe Acne vulgaris: a systematic review and meta-analysis.
The Journal of dermatological treatment · 2026
BACKGROUND: Acne vulgaris is a chronic inflammatory disease and is one of the leading causes of dermatological morbidities among young adults. Doxycycline is widely recommended as first-line therapy for moderate to severe acne; however, its use is limited. OBJECTIVE: To systematically compare the efficacy and safety of oral azithromycin pulse therapy versus doxycycline in patients with moderate… Read on PubMed →
Efficacy and Safety of Non-Cross-Linked Hyaluronic Acid Mesotherapy for Post-Acne Erythema: A Split-Face, Prospective, Randomized, Single-Center Trial.
Journal of cosmetic dermatology · 2026
BACKGROUND: Post-acne erythema (PAE) is one of the most common inflammatory sequelae of acne. Although various therapeutic approaches are currently available, many are limited by suboptimal efficacy, poor tolerability, or high costs. This trial aims to evaluate the clinical efficacy and safety of non-cross-linked hyaluronic acid (HA) mesotherapy for the treatment of PAE. METHODS: A total of 25… Read on PubMed →
Efficacy and Safety of a Dual-Wavelength 589/1319 nm Laser for the Treatment of Acne Erythema: A Split-Face Randomized Controlled Trial.
Journal of cosmetic dermatology · 2026
BACKGROUND: The 589/1319 nm solid-state dual-wavelength (SSDW) laser, which targets cutaneous vasculature, may be an effective treatment for acne erythema (AE). OBJECTIVES: To compare the efficacy and safety of the 589/1319 nm SSDW laser with topical soothing Aloe vera (AV) gel for the treatment of AE. PATIENTS AND METHODS: Thirty patients with bilateral AE were enrolled. One facial side… Read on PubMed →
Anti-quorum-sensing activity of Plectranthus aliciae in multispecies Cutibacterium acnes-Staphylococcus epidermidis systems.
Phytomedicine : international journal of phytotherapy and phytopharmacology · 2026
BACKGROUND: Quorum sensing (QS) is a bacterial communication process mediated by the production, release, and detection of autoinducers, regulating gene expression linked to virulence and biofilm formation. Cutibacterium acnes and Staphylococcus epidermidis exhibit opportunistic pathogenic behavior on the skin, complicating treatment strategies for inflammatory skin conditions such as acne… Read on PubMed →