Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
374 papers
Photoprotective Effects of Dendrobium officinale Protein Hydrolysate Fractions Against UVB-Induced Photoaging Associated with Modulation of MAPK/NF-κB and TGF-β/Smad Signaling.
Molecules (Basel, Switzerland) · 2026
Dendrobium officinale has attracted increasing attention as a functional food because of its diverse biological activities; however, the photoprotective potential of its protein-derived peptides remains poorly understood. In this study, D. officinale protein hydrolysates were fractionated by ultrafiltration according to molecular weight, and their protective effects against ultraviolet B… Read on PubMed →
Innovative Facial Contouring Using a Monopolar Radiofrequency Device with Continuous Water Cooling: An Integrated Clinical and Preclinical Study.
International journal of molecular sciences · 2026
Monopolar radiofrequency (MRF) is a well-established modality for non-invasive facial rejuvenation; however, its clinical utility is frequently constrained by patient discomfort and inconsistent thermal delivery. This study evaluated the efficacy, safety, and mechanistic profile of a novel MRF system incorporating continuous water cooling (RF-CWC) designed to optimize thermal distribution and… Read on PubMed →
Skin health in oncology: evidence-based skin care for cancer patients.
The oncologist · 2026
BACKGROUND: Cancer and its treatments frequently compromise skin integrity, leading to xerosis, pruritus, dermatitis, radiation-induced skin damage, and secondary infections. These cutaneous adverse events (cAEs) are not merely superficial; they profoundly impact patient quality of life (QoL), contributing to physical discomfort, psychosocial distress, and poorer treatment adherence. Even mild… Read on PubMed →
Oleoyl-hyaluronate nanoparticles for enhanced stability and bioactivity of encapsulated coenzyme Q10.
International journal of pharmaceutics · 2026
This study presents the successful encapsulation of coenzyme Q10 (CoQ10) within sodium oleoyl hyaluronate (O-HA; Mw ∼12,000 Da) nanoparticles, creating a concentrated, liquid colloidal dispersion. The nanoprecipitation process achieved high encapsulation efficiency (up to 96%) and a loading capacity of 2.4-3.0 mg·mL-1. The physicochemical properties of these solid polymeric nanoparticles… Read on PubMed →
Development of AI-assisted 3D-printed degradable hydrogel microneedles for transdermal delivery of progesterone-loaded solid lipid nanoparticles: a novel approach to slowing Alzheimer's disease progression.
International journal of pharmaceutics · 2026
Progesterone (PG) is used to slow the progression of neurodegenerative diseases, particularly Alzheimer's disease (AD) in postmenopausal women. However, PG exhibits high lipophilicity, resulting in strong binding to skin tissues and plasma proteins, which may limit its systemic transport via transdermal routes. Solid lipid nanoparticles (SLNs) have been highlighted for their potential to enhance… Read on PubMed →
Neoagarotetraose from Marine Red Algae Ameliorates UVB-Induced Skin Barrier Damage in Mice and HaCaT Keratinocytes.
Marine biotechnology (New York, N.Y.) · 2026
Ultraviolet B (UVB) radiation is a major environmental threat that disrupts skin integrity and drives inflammatory skin disorders. Neoagarotetraose (NA4), a low-molecular-weight oligosaccharide derived from marine red algae, is characterized by high bioavailability and well-documented anti-inflammatory properties, yet its role in UVB-induced skin damage remains unexplored. In this study, we… Read on PubMed →
Atopic dermatitis.
Nature reviews. Disease primers · 2026
Atopic dermatitis (AD) is the most common inflammatory skin disease and carries the highest disability-adjusted life-years burden, ranking 15th among all non-fatal diseases globally. It is characterized by intensely itchy skin and is associated with multiple comorbidities, such as food allergy, asthma, allergic rhinitis and eosinophilic oesophagitis, which are mainly driven by type 2 immune… Read on PubMed →
Oral probiotics and topical secretome to enhance clinical outcomes and microbiome restoration in acne vulgaris: a double-blind, randomised controlled trial protocol.
BMJ open · 2026
BACKGROUND: Acne vulgaris is a chronic inflammatory condition primarily caused by Cutibacterium acnes, which disrupts skin homeostasis, thereby triggering immune responses and sebum metabolism. Dysbiosis is an imbalance in the skin and gut microbiota identified as a significant factor contributing to acne progression. Standard therapy often relies on antibiotics, but the long-term use has… Read on PubMed →
Molecular networking-based GC/MS profiling of Citrus japonica Thunb. peel and pulp lipophilic fractions and their antimicrobial potential against diabetic foot ulcer pathogens.
Scientific reports · 2026
Diabetic ulcers are a serious complication of diabetes, often exacerbated by microbial infections that hinder wound healing. This study investigates the antimicrobial potential of non-polar constituents derived from the peel and pulp of Citrus japonica (kumquat) as natural antimicrobial agents for managing microbial infections associated with diabetic ulcers. Gas Chromatography-Mass Spectrometry… Read on PubMed →
Development and validation of a comprehensive in vitro organ model for androgenetic alopecia.
BMC biotechnology · 2026
BACKGROUND: Male androgenetic alopecia (AGA) is the most common hair loss disorder. However, research on AGA remains limited, primarily due to the lack of clinical samples and imperfect AGA models incapable of replicating the androgen sensitivity of AGA. METHODS: An AGA organ model was established by optimizing the concentration of dihydrotestosterone (DHT) and simulating AGA pathology through… Read on PubMed →
pH-responsive smart hydrogel dressing for controlled antimicrobial therapy and accelerated wound healing.
Journal of materials chemistry. B · 2026
Bacterial wound infections pose a major clinical challenge, often causing delayed healing, recurrent infections, and increased antibiotic resistance. Conventional antibiotics are largely ineffective against biofilm-associated bacteria, underscoring the need for advanced antimicrobial approaches. Silver nanoparticles (AgNPs) exhibit potent, broad-spectrum antibacterial activity, but their clinical… Read on PubMed →
The efficacy and safety of a 577 nm diode laser in the treatment of cutaneous warts: A prospective single-arm study.
Lasers in medical science · 2026
Warts are a common skin disease caused by the human papillomavirus. While many treatments exist, none are entirely effective. Our objective is to study the efficacy and safety of a 577 nm diode laser in the treatment of cutaneous warts due to its strong oxyhemoglobin absorption for targeting wart vasculature. Patients with common warts (n = 31) were enrolled in this prospective study. Patients… Read on PubMed →
"Dual-Bottle, Dual-Mode" Intelligent Delivery System for Scenario-Specific Delivery of Astaxanthin and Skin Photoaging Protection.
ACS applied materials & interfaces · 2026
Astaxanthin (AX) faces several challenges in topical skin applications, including poor water solubility, low photostability, undesirable staining, and uncontrolled release. To address these, this study developed a "dual-bottle, dual-mode" intelligent delivery system. First, sulfobutylether-β-cyclodextrin (SBE-β-CD) inclusion technology was used to prepare an AX@SBE-β-CD inclusion complex, greatly… Read on PubMed →
Comparative effects of hyaluronic acid-amino acid and polynucleotide mixtures on extracellular matrix gene expression in human dermal fibroblasts.
Journal of wound care · 2026
OBJECTIVE: The extracellular matrix (ECM) provides structural and functional support for skin. Strategies that stimulate fibroblast activity and ECM synthesis are key in regenerative and aesthetic medicine. The aim of the study was to compare the effects of a hyaluronic acid plus six-amino acid formulation (HA6AA) with a polynucleotide mixture (PN) on extracellular matrix (ECM)-related gene… Read on PubMed →
Decoding Cyclodextrins in Skin Applications: Structure, Mechanisms, and Safety in Cosmetic and Dermatologic Formulations (Part I).
International journal of molecular sciences · 2026
Cyclodextrins (CDs) have emerged as important encapsulation platforms in dermatologic and cosmetic sciences, addressing critical challenges related to the solubility and stability of bioactive compounds. This review (Part I) systematically explores the relationship between the molecular architecture of CDs and their functional performance at the skin interface. A comprehensive analysis of the… Read on PubMed →
Wearable Colorimetric Biosensor Based on Copper Coordination Polymer Nanozymes for Noninvasive Monitoring of Ascorbic Acid.
Langmuir : the ACS journal of surfaces and colloids · 2026
Real-time monitoring of ascorbic acid (AA) in sweat is critical for evaluating oxidative stress and nutritional status. However, the practical application of current wearable sensors is often compromised by complex matrix interference and interfacial instability during physical activity. To address these challenges, we developed a high-performance wearable colorimetric sensing platform based on… Read on PubMed →
INDIVIDUAL ARTICLE: Efficacy of a Dual-Serum Cosmetic System in Women With Female Pattern Hair Loss.
Journal of drugs in dermatology : JDD · 2026
Hair loss is a widespread condition with a potentially severe psychological burden, especially among women. The chance of suffering from female alopecia increases with menopause, and topical treatments beyond minoxidil are scarce. Over the past several years, new combinations of natural ingredients and patented mixtures have shown promising results to improve hair shedding, thus helping recover… Read on PubMed →
Clay-polysaccharides as engineered nanoplatforms for cancer treatment.
Carbohydrate polymers · 2026
This review highlights recent advances in designing bionanocomposites that combine clay minerals with polysaccharides as multifunctional platforms for cancer therapy. Polysaccharides such as chitosan, hyaluronic acid, alginate, pectin and cellulose derivatives offer biocompatibility, biodegradability and versatile chemical functionality, while clays including montmorillonite, sepiolite, halloysite… Read on PubMed →
Aesthetic Concerns and Nonsurgical Treatment Trends in Patients With GLP-1 Agonist-Associated Weight Loss.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2026
BACKGROUND: Weight loss associated with glucagon-like peptide-1 (GLP-1) agonists is frequently accompanied by reduced facial fat, sagging skin, and stubborn pockets of body fat. OBJECTIVE: To identify aesthetic concerns related to GLP-1 agonist-associated weight loss and current nonsurgical treatment trends. MATERIALS AND METHODS: An electronic survey was sent to health care professionals (HCPs)… Read on PubMed →
GLP-1-Induced Weight Loss and the Face: Anatomical Mechanisms and Rationale for Collagen-Stimulating and Volumizing Aesthetic Treatments.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2026
BACKGROUND: Glucagon-like peptide-1 (GLP-1) receptor agonists have transformed medical weight-loss therapy and have been associated with characteristic facial changes, including hollowing, skin laxity, and contour alterations that may accentuate pre-existing signs of aging. OBJECTIVE: To review the anatomical basis of facial changes after GLP-1-associated weight loss and provide an evidence-based… Read on PubMed →