Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
374 papers
Exploring the Lived Experience of Acne in the United States and the United Kingdom: Social Media Analysis.
JMIR dermatology · 2026
BACKGROUND: Acne is a chronic skin condition that primarily affects adolescents and young adults but can persist into adulthood. It can have repercussions on physical and mental health, self-esteem, and body image. The increasing use of social media for health information and peer support offers an opportunity to explore real-life experiences with acne. OBJECTIVE: This study aims to analyze… Read on PubMed →
Efficacy of hydrocolloid dressing for hand-foot skin reaction: J-SUPPORT 1701 APRON trial.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
PURPOSE: Since hand-foot skin reaction (HFSR) is a dose-limiting toxicity associated with certain multikinase inhibitors, prophylactic measures to manage this adverse effect require improvement. This study aimed to evaluate the efficacy of depressurization using hydrocolloid dressing by comparing the effects of adding hydrocolloid dressing to standard prophylactic moisturizing versus moisturizing… Read on PubMed →
IL-4/IL-13-Driven Dysregulation of Epidermal Lipid Metabolism in Atopic Dermatitis: An Immunometabolic Link Between Type 2 Inflammation and Barrier Dysfunction.
Cells · 2026
Atopic dermatitis (AD) is a chronic immune-mediated inflammatory skin disease characterized by a complex and dynamic interplay between immune dysregulation and epidermal barrier dysfunction. Emerging evidence supports an integrated pathogenic model in which immune activation and barrier impairment form a bidirectional and self-reinforcing axis rather than representing separate processes. This… Read on PubMed →
High-Level Secretory Expression of Recombinant Type XVII Human-like Collagen in Komagataella phaffii.
International journal of molecular sciences · 2026
Type XVII collagen (COL17) is crucial for skin integrity but difficult to produce. To achieve high-level secretory expression, a human COL17 segment was designed and cloned into the pPIC9K vector with six different α-mating factor signal peptides and integrated into Komagataella phaffii GS115. Fed-batch fermentation in a 5 L bioreactor yielded 4.7 g/L of recombinant COL17. Functional assays showed… Read on PubMed →
Usnic Acid and Its Topical Use-A Concise Review.
Molecules (Basel, Switzerland) · 2026
Usnic acid (UA), a prominent lichen secondary metabolite, exhibits a unique dual therapeutic profile in dermatology, though its clinical translation is limited by systemic hepatotoxicity and poor solubility. This review comprehensively evaluates the topical efficacy, molecular mechanisms, and advanced formulation strategies of UA enantiomers and UA-rich extracts. A literature search across PubMed… Read on PubMed →
Skin Cells' Protection Against UVA-Induced Changes in Co-Cultured Keratinocytes-Fibroblasts' Proteome and Released Signaling Proteins by 3-O-Ethyl Ascorbic Acid.
International journal of molecular sciences · 2026
UVA radiation affects communication between the cells that create the human skin. To prevent UVA-induced damage, there is a constant search for compounds protecting all skin cells and homeostasis in their communication. Therefore, the aim of this study was to evaluate the effect of 24 h incubation with 3-O-ethyl ascorbic acid (EAA; 150 µM) on the intracellular proteome of co-cultured keratinocytes… Read on PubMed →
Pachydermoperiostosis (Touraine-Solente-Gole syndrome): A case report and literature review.
Medicine · 2026
RATIONALE: Pachydermoperiostosis (PDP) is a rare genetic disorder characterized by the triad of pachyderma, digital clubbing, and periostosis. We report the case of a 17-year-old male who presented with classic clinical features over 3 years, including progressive skin thickening on the forehead, joint pain and swelling, hyperhidrosis, and facial oiliness, leading to a clinical and radiological… Read on PubMed →
Microscopic Fungi as Sources of Natural UV-Protective Compounds.
Current microbiology · 2026
The search for sustainable and biocompatible alternatives to synthetic sunscreens has intensified due to concerns about the safety and environmental persistence of conventional UV filters. Although algae and bacteria have been extensively explored as sources of photoprotective metabolites, microscopic fungi remain comparatively neglected despite remarkable metabolic diversity and ecological… Read on PubMed →
Lawsone modulates oxidative stress, apoptosis, and enhances growth factor expression in human dermal fibroblasts under hyperglycemic conditions.
Molecular biology reports · 2026
INTRODUCTION: Delayed wound healing is a serious issue in diabetes, which is driven by metabolic and non-metabolic factors. Dysfunction and decreased lifespan of fibroblast cells play a key role in this condition. Lawsone (2-hydroxy-1,4-naphthoquinone), the main active component of Lawsonia inermis, is well known for its anticancer and regenerative effects, although these effects vary depending on… Read on PubMed →
Metal-Polyphenol Network Confined Synthesis of Nanozymes with Programmable Oxygen Vacancies for UVB Photodamage Therapy.
Nano letters · 2026
Conventional sunscreens block ultraviolet B (UVB) but fail to scavenge accumulated reactive oxygen species (ROS), causing severe photodamage. Herein, we develop a room-temperature, aqueous coordination strategy that assembles metal-polyphenol networks (MPNs) to confine in situ nucleation and growth of metal oxide nanozymes. Utilizing tannic acid coordinated ceria (CeO2-TA) as a model system, we… Read on PubMed →
Bloodstream Infection in an Immunocompromised Host After Unusual Presentation of Photo Recall Dermatitis.
The American journal of case reports · 2026
BACKGROUND Photo recall dermatitis (PRD) is a phototoxic eruption that occurs in areas of previous ultraviolet-damaged skin following systemic administration of a drug, most commonly chemotherapeutic medications. Although generally considered a self-limited dermatologic phenomenon, its implications in immunocompromised patients have not been well characterized. Secondary infection complicating PRD… Read on PubMed →
Advances in Scalp Microbiome Research: Molecular Insights into the Metabolism-Inflammation-Barrier Axis and Dandruff Pathogenesis.
Molecules (Basel, Switzerland) · 2026
Dandruff (DF) is a prevalent, recurrent inflammatory scalp disorder increasingly recognized as a complex state of functional dysbiosis rather than a simple Malassezia overcolonization. The scalp microbiome is predominantly shaped by Malassezia species (M. restricta and M. globosa), Cutibacterium, and Staphylococcus species. Recent multi-omics evidence indicates that DF pathogenesis is driven by… Read on PubMed →
Mechanism of Inonotus hispidus in treating melasma: integrated in vivo, in vitro, network pharmacology and untargeted metabolomics investigation.
Journal of ethnopharmacology · 2026
ETHNOPHARMACOLOGICAL RELEVANCE: Inonotus hispidus (Bull.) P. Karst. is a traditional Chinese medicine (TCM) with a long history. Although its use in treating melasma was documented in the Bencaogangmu, its therapeutic mechanism remains unexplored and is poorly understood in modern research. AIM OF THE STUDY: To investigate the mechanism of Inonotus hispidus extract in treating melasma. MATERIALS… Read on PubMed →
Discovery of an Androgen Receptor Degrader Featuring a Pyridazinyl Glutarimide CRBN-Binding Motif for Transdermal Treatment of Androgenetic Alopecia.
Journal of medicinal chemistry · 2026
Androgenetic alopecia (AGA) is primarily driven by overexpression of androgen receptor (AR) in hair follicles, leading to androgen hypersensitivity and progressive follicular miniaturization. Although PROTAC degraders offer the potential for sustained AR downregulation, their application in AGA has been limited by poor solubility and skin permeability. In this study, we incorporated pyridazinyl… Read on PubMed →
Structure-Based Virtual Screening and Mechanistic Characterization of Methotrexate and Selinexor as Potent Anti-Melanogenic Agents via Multi-Pathway Suppression of MITF.
Cells · 2026
Tyrosinase is a pivotal therapeutic target for hyperpigmentation disorders, yet current inhibitors frequently exhibit limited potency and suboptimal safety. Here, we employed structure-based virtual screening of an FDA-approved drug library against a refined human tyrosinase homology model, identifying methotrexate and selinexor as potent anti-melanogenic candidates. Both compounds markedly… Read on PubMed →
A skin-hypothalamus axis couples heat stress and metabolic dysfunction.
Cell · 2026
With the ongoing rise in global temperatures, the prevalence of heat-stress-related chronic health disorders has increased. However, whether heat stress has an enduring impact on metabolic health remains unclear. Here, we report that mice exposed to heat stress were more susceptible to metabolic dysfunction upon subsequent exposure to an obesogenic diet. Upon heat stress, we found that elevated… Read on PubMed →
Injectable VEGF-loaded gelatin-hyaluronic acid hydrogel to synergistically promote flap survival via rapid angiogenesis.
Journal of materials chemistry. B · 2026
Random-pattern skin flaps are commonly used in plastic surgery to close skin defects, but necrosis often occurs in the distal portions of flaps due to insufficient blood supply, which severely limits their clinical utility. Thus, we developed a vascular endothelial growth factor (VEGF)-loaded injectable hydrogel to promote local angiogenesis to improve skin flap survival. The hydrogel, composed of… Read on PubMed →
DGAT1 regulates keratinocyte proliferation through the modulation of retinoid homeostasis.
Journal of physiology and biochemistry · 2026
Multiple mechanisms contribute to skin barrier integrity, and emerging evidence suggests that acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) plays a key role in its regulation through both lipid and retinoid metabolism. Although DGAT1 deficiency leads to cutaneous abnormalities, the direct role of DGAT1 in keratinocyte biology remains unclear. Here, we show that DGAT1 deficiency drives… Read on PubMed →
CBD-Containing Hemp Extracts and Isolated CBD for Acne: A Systematic Review of Anti-Inflammatory Mechanisms, Clinical Signals and Sustainability.
Molecules (Basel, Switzerland) · 2026
Industrial hemp (Cannabis sativa L.) has emerged as a sustainable source of bioactive compounds, with increasing interest in cosmeceutical applications for acne management. This systematic review synthesises evidence on cannabinoid-containing hemp extracts, particularly cannabidiol (CBD), with emphasis on anti-inflammatory and sebostatic mechanisms, alongside formulation considerations and… Read on PubMed →
Development and characterization of dibenzalacetone-loaded oleogels as a potential photoprotective agents for sunscreen formulations.
Scientific reports · 2026
Prolonged exposure to ultraviolet radiation induces erythema, accelerates photoaging, and increases the risk of skin cancer. Sunscreens are the primary strategy for preventing UV-induced skin damage; however, the effective topical delivery of photoprotective agents is often limited by formulation challenges. Dibenzalacetone (DBA), a chalcone derivative with broad UVA and UVB absorption, exhibits… Read on PubMed →