Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
374 papers
Distinct polyp recurrence timing and STK11 mutation status underlie clinical heterogeneity in pediatric Peutz-Jeghers syndrome.
Journal of pediatric gastroenterology and nutrition · 2026
OBJECTIVES: Clinically, recurrent polyp growth is a characteristic feature of pediatric Peutz-Jeghers syndrome (PJS) patients. However, the clinical characteristics of pediatric PJS patients grouped by postoperative recurrence time remain undefined. Furthermore, differences in clinical features between serine/threonine kinase 11 (STK11)-positive and -negative patients, and the influence of STK11… Read on PubMed →
Gastric outlet obstruction secondary to Peutz-Jeghers syndrome successfully managed by polypectomy.
Clinical journal of gastroenterology · 2026
Peutz-Jeghers syndrome (PJS) is a genetic disorder characterized by the development of hamartomatous polyps throughout the gastrointestinal tract but primarily in the small bowel. Gastric outlet obstruction (GOO) due to PJS polyps is rare in childhood. The optimal treatment of large, gastric polyps in PJS remains unclear. We report herein the case of a 1-year-old, male patient who was treated… Read on PubMed →
A novel ZIC1-BMP4 axis identified in photoaged dermal fibroblasts regulates melanogenesis.
Journal of dermatological science · 2026
BACKGROUND: Chronic ultraviolet exposure induces photoaging and pigmentation, contributing to disorders such as melasma. However, treatments for photoaging-related pigmentation still challenging, implying upstream regulators remain incompletely understood. OBJECTIVES: To identify the key regulators involved in photoaging-related pigmentation. METHODS: We integrated bulk RNA-seq data of… Read on PubMed →
Analysis of self-management behaviors and related factors in patients with postherpetic neuralgia: A multidimensional methodological study.
Geriatric nursing (New York, N.Y.) · 2026
OBJECTIVE: This study aimed to evaluate the current state of self-management behaviors among patients suffering from postherpetic neuralgia (PHN) and to ascertain the principal determinants of these behaviors. METHODS: From March to July 2024, 268 PHN inpatients were enlisted from the Pain Department of Guizhou Medical University Hospital through a convenience sampling method. Data were gathered… Read on PubMed →
A randomized controlled trial of 3% polidocanol foam with saline prewashing compared with standard foam sclerotherapy for the treatment of varicose veins.
Journal of vascular surgery. Venous and lymphatic disorders · 2026
BACKGROUND: Chronic venous disease is a highly prevalent global condition. Sclerotherapy with polidocanol foam is an established minimally invasive treatment. However, complications such as postprocedural hyperpigmentation remain common, and the maximum injectable volume per session may limit treatment efficacy. These factors highlight the need for optimized techniques to enhance vein occlusion… Read on PubMed →
Clinical characteristics and factors affecting quality of life in children with congenital adrenal hyperplasia.
Pakistan journal of pharmaceutical sciences · 2026
BACKGROUND: Congenital Adrenal Hyperplasia (CAH) is a group of disorders characterized by impaired adrenal steroid hormone synthesis, with a wide spectrum of clinical manifestations. The prognosis of CAH depends on factors, such as clinical phenotype, treatment and management. OBJECTIVES: To analyze the factors influencing the quality of life in children with CAH. METHODS: This retrospective… Read on PubMed →
Successful Management of a Facial Traumatic Asphalt Tattoo Using Sequential Q-Switched Nd:YAG and Fractional CO₂ Lasers.
Lasers in surgery and medicine · 2026
OBJECTIVES: To describe a stepwise, non-invasive dual-laser approach for the treatment of a traumatic facial asphalt tattoo. METHODS: A 30-year-old woman presented 18 months after a motor vehicle accident with a persistent dyschromic, atrophic plaque containing embedded asphalt particles on the right hemiface. A 12-session treatment strategy combining Q-switched Nd:YAG laser (1064 nm; 4-5 ns… Read on PubMed →
Efficacy and safety of hemostatic net in facelift and rejuvenation surgeries (browlift and necklift): A systematic review and meta-analysis.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS · 2026
BACKGROUND: Facelifts are commonly associated with postoperative complications. The hemostatic net has emerged as a promising approach to reduce these events. The aim of this meta-analysis was to evaluate the efficacy and safety of the hemostatic net in facelift. METHODS: The PubMed, Embase, and Cochrane databases were systematically searched up to May 2025 for studies evaluating the hemostatic… Read on PubMed →
Efficacy of Alexandrite picosecond laser therapy with and without dermal polyrevitalisation (NCTF® 135 HA) in patients with melasma: A Randomised Controlled Trial.
La Clinica terapeutica · 2026
OBJECTIVES: This randomised controlled trial aimed to compare the efficacy of Alexandrite picosecond laser therapy combined with dermal polyrevitalisation (NCTF® 135 HA) with laser therapy alone for reducing the severity of melasma. The outcomes were assessed using 3D imaging and the Dermatology Life Quality Index (DLQI). The secondary objectives were to evaluate the safety and tolerability of the… Read on PubMed →
Tranexamic acid protects human dermal fibroblasts from D-galactose-induced senescence via the GPR30/MAPK pathway.
Annals of medicine · 2026
BACKGROUND: Tranexamic acid (TXA) is widely used for pigmentary disorders, but its anti-ageing potential remains unclear. This study aimed to evaluate whether topical 3% TXA improves early periorbital wrinkles in women with facial melasma and to investigate whether TXA protects human dermal fibroblasts from D-galactose-induced senescence via the GPR30/MAPK pathway. METHODS: Fifty women with… Read on PubMed →
Bone Marrow Mesenchymal Stem Cell Extracellular Vesicle Treatment of Respiratory Failure from COVID-19: Endpoint Analysis of Expanded Access Safety Trial.
Stem cell reviews and reports · 2026
The safety of an extracellular vesicle (EV) enriched secretome from bone marrow mesenchymal stem cells (BM-MSCs) was evaluated in a multi-site, prospective, expanded access trial as potential treatment for respiratory failure due to COVID-19. Subjects (103) received up to three doses of 15 mL IP every 72 h. The primary outcome was all cause 60-day mortality. Secondary outcomes included serious… Read on PubMed →
Safety and Tolerability of Fractional CO2 Lasers for Facial Rejuvenation Across Fitzpatrick Skin Phototypes I-IV: Retrospective Cohort Study.
Journal of cosmetic dermatology · 2026
BACKGROUND: Fractional CO2 laser is an effective treatment for skin rejuvenation, although pigmentary complications remain a clinical consideration. Newer generation fractional CO2 laser systems include pulse modes such as HighPulse (HP), which deliver high energy over a shortened dwell time, reducing the duration of energy delivery per microbeam with the aim of limiting thermal diffusion beyond… Read on PubMed →
Adrenocortical Carcinoma in Peutz-Jeghers Syndrome With a Rare STK11 Pathogenic Germline Variant: A Case Report.
Cancer reports (Hoboken, N.J.) · 2026
BACKGROUND: Peutz-Jeghers syndrome (PJS) is an inherited, autosomal-dominant condition, featuring STK11 germline mutations, characterized by hamartomatous gastrointestinal polyps and increased cancer risk. The most commonly associated malignancies are gastrointestinal, pancreatic, and breast cancers. Herein, we report an extremely rare case of PJS with adrenocortical carcinoma (ACC). CASE: A… Read on PubMed →
Thoracic Botox Injections for Refractory Notalgia Paresthetica.
Pain medicine case reports · 2026
BACKGROUND: Notalgia paresthetica is a chronic neuropathic pruritus at the thoracic interscapular and paravertebral region. CASE REPORT: A 30-year-old man with a history of diabetes presented to the clinic with left periscapular pain. The patient had chronic, burning, pruritic pain localized to the left mid-thoracic paraspinal region and a well-demarcated hyperpigmentation over the affected area… Read on PubMed →
Exploring the mechanism of differential responses to combination therapy in melasma: pigmentary versus mixed pigmentary-vascular types-a clinical study based on interaction analysis.
The Journal of dermatological treatment · 2026
BACKGROUND: Melasma shows clinical heterogeneity, but the role of vascular components in treatment resistance remains unclear. METHODS: This retrospective cohort study included 75 melasma patients stratified by severity (mild/moderate/severe, n = 25 each) and classified into pure pigmentary (M-type, n = 42) and mixed pigmentary-vascular (M + V-type, n = 33). All received low-fluence Q-switched… Read on PubMed →
A Case Report: Treatment, follow-up, and literature review of type A insulin resistance syndrome caused by a De Novo INSR c.3328G>C mutation.
Frontiers in endocrinology · 2026
BACKGROUND: Type A insulin resistance syndrome (TAIRS) is a rare inherited disorder caused by mutations in the insulin receptor (INSR) gene. It is characterized by severe insulin resistance, hyperandrogenism, and acanthosis nigricans. Its clinical manifestations overlap with those of polycystic ovary syndrome (PCOS), making it prone to misdiagnosis, particularly in adolescent females. Currently… Read on PubMed →
Lasers for Melasma.
Dermatologic clinics · 2026
Melasma is a chronic pigmentary condition with a multifactorial pathophysiology, involving melanin overproduction, photoaging, and hormonal factors, making treatment challenging. Lasers and light-based devices, including intense pulsed light, photobiomodulation, Q-Switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser, nanosecond laser, picosecond laser, nonablative fractional laser and… Read on PubMed →
Fading the spots: a pilot case series of partial unilateral lentiginosis treated with Q-switched Nd: YAG laser.
Annals of medicine · 2026
INTRODUCTION: Partial unilateral lentiginosis (PUL) is rare pigmentary disorder characterized by clusters of unilateral lentiginous macules that can cause significant cosmetic and psychosocial distress. Despite its benign nature, there is no established standard treatment, and existing options often yield inconsistent results. This pilot case series evaluated the efficacy and safety of the… Read on PubMed →
Platelet-Rich Plasma and Platelet-Rich Fibrin in Periorbital Esthetics: Systematic Review and Clinical Applications.
Facial plastic surgery clinics of North America · 2026
This systematic review evaluates the effectiveness of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) for periorbital rejuvenation, updating a previous 2021 review. Twenty-six studies were included with notable variability in preparation methods limiting clear conclusions. Patient satisfaction was high with PRP/PRF treatment, which was only moderately effective for periorbital… Read on PubMed →
Skin side-effects of elexacaftor-tezacaftor-ivacaftor: a real-world view.
Respiratory medicine and research · 2026
BACKGROUND: Since 2020, ETI (elexacaftor/tezacaftor/ivacaftor) has been used to treat patients with cystic fibrosis. Acne and rash are listed as "common" and "very common" adverse effects in the Summary of Product Characteristics for ETI, affecting between 2-5% and 10% of patients respectively. Patients have, however, shared their experience of developing acne and rashes with clinicians and on… Read on PubMed →