Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
374 papers
Beyond T helper 2 cells: Integrating immune, barrier, microbial, and neuroimmune pathways in atopic dermatitis pathogenesis.
Journal of the American Academy of Dermatology · 2026
Atopic dermatitis is a heterogeneous inflammatory skin disease long-defined by skin barrier dysfunction and type 2 (T helper cell [Th]2) immune dysregulation. Dupilumab established interleukin (IL)-4 and IL-13 as key therapeutic targets, yet partial response rates underscore contributions from Th1, Th17, Th22, and other pathways that vary by age, ethnicity, and disease stage. Cytokine signaling… Read on PubMed →
Basic skin care for atopic dermatitis.
Journal of the American Academy of Dermatology · 2026
Basic skin care for atopic dermatitis (AD) management may impact the skin barrier, pruritus, and skin inflammation. Moisturizers and appropriate bathing practices are recommended for all patients with AD, regardless of disease severity. Wet-wrap therapy is typically reserved for patients with moderate-to-severe AD to control flares or manage recalcitrant disease. Although high-quality evidence… Read on PubMed →
Research hotspots and emerging frontiers in photodynamic therapy for basal cell carcinoma: A global bibliometric analysis (2001-2025).
Photodiagnosis and photodynamic therapy · 2026
BACKGROUND: Basal cell carcinoma (BCC) is the most prevalent cutaneous malignancy. It correlates strongly with ultraviolet exposure. The incidence of BCC continues to climb annually. Consequently, the demand for safe, cosmetically favorable, and highly effective therapies is pressing. Photodynamic therapy (PDT) has captured significant research interest due to its therapeutic efficacy against BCC… Read on PubMed →
Dandruff Is a Low-Grade Inflammatory Condition Featuring Hyperproliferative Keratinocytes, Interleukin-17-Producing T Cells, and N-Acyl Ethanolamines.
Immunity, inflammation and disease · 2026
BACKGROUND: Dandruff features epidermal scaling but lacks overt signs of inflammation, such as erythema. Characterisation of its inflammatory profile may improve understanding of the underlying inflammatory mechanisms and therefore indicate alternative approaches for treatment. METHODS: Full-thickness scalp biopsies were sampled from healthy volunteers and those with dandruff… Read on PubMed →
Gut microbiota and the kidney-gut-skin axis in chronic kidney disease-associated pruritus: mechanisms and therapeutic implications.
Frontiers in cellular and infection microbiology · 2026
Chronic kidney disease-associated pruritus (CKD-aP) is a highly prevalent and debilitating symptom in patients with chronic kidney disease (CKD) and end-stage kidney disease (ESKD), severely impairing quality of life, sleep quality, mental health, and clinical outcomes. Its pathogenesis is multifactorial and remains incompletely understood, involving chronic inflammation, immune imbalance… Read on PubMed →
Extracellular vesicles in atopic dermatitis: unraveling pathogenic mediators and engineering therapeutic vectors.
Frontiers in immunology · 2026
Atopic dermatitis (AD) is a complex chronic inflammatory skin disease whose pathogenesis involves a vicious cycle of epidermal barrier defects, immune dysregulation, and microbial imbalance. Despite advances in targeted biologics and small-molecule drugs, there remains an unmet clinical need for safe, effective treatments that can simultaneously intervene in multiple pathological processes… Read on PubMed →
Dual targeting of cutaneous inflammation and vasculopathy via STING-NF-κB blockade underlies the anti-psoriatic efficacy of Yinxie Granules.
Chinese journal of natural medicines · 2026
Psoriasis is a chronic skin disease driven by skin inflammation and abnormal subcutaneous blood vessels. Yinxie Granules (YXKL) is a clinically effective traditional Chinese medicine (TCM) formula that has shown promise in psoriasis treatment, but its pharmacological mechanisms and material basis remain unclear, limiting its clinical application and co-administration with other drugs. In this… Read on PubMed →
Noninvasive Diagnosis Revealed a Strong Therapeutic Response and Skin Barrier Changes in Hemoporfin-Mediated Photodynamic Therapy for Port-Wine Stains.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026
BACKGROUND: Noninvasive skin imaging, such as reflectance confocal microscopy (RCM) and optical coherence tomography (OCT), has been extensively used to collect objective clinical data and assess the morphological and ultrastructural change of tissue. However, the application of these noninvasive diagnosis techniques for the therapeutic evaluation of hemoporfin-mediated photodynamic therapy… Read on PubMed →
Carvotanacetone from Saposhnikoviae radix restores skin barrier by regulating SP1 and Claudin-1.
General physiology and biophysics · 2026
This study aimed to investigate how Saposhnikoviae radix regulates skin barrier function. Bioinformatics analysis was conducted to identify the compounds in Saposhnikoviae radix and their target genes related to cell barrier function. Molecular docking analysis was performed to investigate the interaction between carvotanacetone (CARV) and key genes. The impact of CARV on skin barrier function was… Read on PubMed →
Effects of Selective Sphingosine-1-Phosphate Receptor 1 Agonist, TRV045, on Evoked Pain Tests: An Exploratory, Four-Way Cross-Over Study in Healthy Volunteers.
European journal of pain (London, England) · 2026
INTRODUCTION: Preclinical evidence suggests that dysregulation of the ceramide-sphingosine-1-phosphate (S1P) axis may have analgesic properties. However, currently approved S1PR1 modulators such as fingolimod are hindered for this indication as they induce lymphopenia. The aim of the current study was to evaluate whether the novel, selective S1PR1 agonist TRV045 has analgesic effects in a… Read on PubMed →
The Toxin of the Year: Airborne PM2.5.
Dermatitis : contact, atopic, occupational, drug · 2026
Particulate matter (PM) with a diameter of 2.5 µm or smaller (PM2.5) has emerged as a critical environmental toxin affecting skin health. In light of its widespread and often underestimated impact, we designated PM2.5 as the "toxin of the year." Although PM2.5 primarily affects the respiratory system, growing evidence indicates that it also plays a significant role in cutaneous health. Exposure to… Read on PubMed →
Alpinia zerumbet-Derived Extracellular Vesicles Protect Against UVB-Induced Photoaging by Enhancing Mitochondrial Bioenergetics and Skin Barrier Function.
BioFactors (Oxford, England) · 2026
Ultraviolet B (UVB) radiation is a major cause of skin photoaging by oxidative stress, mitochondrial dysfunction, and barrier disruption. Plant-derived extracellular vesicles (PDEVs) have emerged as promising bioactive nanocarriers, but their roles in mitochondrial regulation and skin barrier homeostasis remain unclear. This study aimed to investigate the protective effects of extracellular… Read on PubMed →
Intense Pulsed Light Combined with Fractional CO2 Laser for Post-traumatic Hyperpigmentation: A Retrospective Study.
Aesthetic plastic surgery · 2026
INTRODUCTION: Post-traumatic hyperpigmentation (PTH) is a pigmentary condition that develops after cutaneous injury from abrasions, burns, procedures, or chemical irritation. Its course can be prolonged and cosmetically distressing, especially when involving visible areas. Although intense pulsed light (IPL) and fractional CO2 lasers are widely used for pigmentary disorders and scar treatment… Read on PubMed →
Five Steps for Effective Office-Based Neck Ultrasound-Assisted Liposuction Under Local Anesthesia: Patient Outcomes.
Aesthetic plastic surgery · 2026
BACKGROUND: The lower face, particularly the neck contour, is an essential element of facial rejuvenation. One of the most effective tools for removing accumulating fat and redraping the neck skin is liposuction, requiring appropriate patient selection for the procedure. METHODS: This retrospective study included patients who underwent office-based neck USS-assisted liposuction under local… Read on PubMed →
The relationship between clinical characteristics of melasma and sunscreen use in women: A cross-sectional, two-center study.
Clinics in dermatology · 2026
Melasma is associated with genetic factors, UV-light exposure, and hormonal influences. Because UV exposure is a crucial factor in the pathogenesis of melasma, the preventive effect of sunscreen use has been established. This cross-sectional study investigated the relationship between the clinical features of melasma and sunscreen use among 126 women attending outpatient dermatology clinics at two… Read on PubMed →
Assessing the Safety and Efficacy of Picosecond Alexandrite Lasers in the Management of Melasma: A Systematic Review and Meta-Analysis of Randomised Control Trials.
The Australasian journal of dermatology · 2026
Melasma is a chronic hyperpigmentation disorder that disproportionately affects women and individuals with darker skin types, leading to a significant psychosocial burden. This meta-analysis aims to evaluate the safety and efficacy of the 755-nm picosecond alexandrite laser (PSAL) compared with conventional therapies in the management of melasma. PubMed, Ovid Medline, Embase, Cochrane Library, and… Read on PubMed →
Interferon Alpha-2a as Treatment for Primary Acquired Melanosis With Atypia and for Primary Acquired Melanosis With Atypia Surrounding Conjunctival Melanoma.
American journal of ophthalmology · 2026
PURPOSE: To report on topical treatment with interferon (IFN) alfa-2a for conjunctival primary acquired melanosis (PAM) with atypia. DESIGN: A retrospective interventional case series. SUBJECTS: Patients diagnosed with PAM with atypia. METHODS: Patients received topical IFN α-2a, IFN α-2b, or pegylated IFN α-2a. Treatment duration, response, adverse effects, and progression-free survival (PFS)… Read on PubMed →
Incidence of Bleomycin-Induced Hyperpigmentation in Patients Undergoing Sclerotherapy for Low-Flow Vascular Malformations.
Journal of vascular and interventional radiology : JVIR · 2026
PURPOSE: To determine the incidence of bleomycin-induced hyperpigmentation in patients receiving bleomycin sclerotherapy for low-flow vascular malformations (LFVMs). MATERIALS AND METHODS: A retrospective chart review of patients with radiologically confirmed LFVM who had undergone ≥1 bleomycin sclerotherapy session. Treatments were performed at Vancouver General Hospital or British Columbia's… Read on PubMed →
Contribution of sclerotherapy to the management of chronic venous insufficiency at the Abidjan Heart Institute: A preliminary study.
Vascular diseases (Paris, France) · 2026
INTRODUCTION: Sclerotherapy is a minimally invasive technique that offers an effective alternative to surgical management of chronic venous insufficiency. Despite its growing use worldwide, its application remains underreported in Sub-Saharan Africa. This preliminary study aims to evaluate the clinical outcomes and therapeutic value of sclerotherapy in patients with superficial chronic venous… Read on PubMed →
Fibroblast-directed melanocyte recruitment via Cxcl12-Cxcr4 axis promotes post-inflammatory hyperpigmentation and skin barrier protection in zebrafish.
Journal of genetics and genomics = Yi chuan xue bao · 2026
Post-inflammatory hyperpigmentation (PIH) is a common skin disorder characterized by brown or black macules. It can be categorized as transient, typically resolving within 6-12 months, or permanent, persisting for years. While the pathogenesis of PIH is commonly linked to localized melanocyte overactivation, the precise cellular and molecular basis for this dysregulation, as well as its… Read on PubMed →