Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
374 papers
Recent Advances in Novel Drug Delivery Systems for the Management of Cutaneous Squamous Cell Carcinoma.
International journal of nanomedicine · 2026
Cutaneous squamous cell carcinoma (cSCC) is a type of cancer that originates from the growth of skin cells. It represents the second most common form of non-melanoma skin cancer and primarily arises from the malignant proliferation of keratinocytes in the epidermis or skin appendages. The global incidence of cSCC is increasing, and its onset is primarily associated with prolonged exposure to… Read on PubMed →
Hyaluronidase Reverses the Effect of Hyaluronic Acid Without Destroying Normal Skin Structure.
Journal of cosmetic dermatology · 2026
BACKGROUND: Dermal fillings based on hyaluronic acid have been widely used in facial rejuvenation. A number of studies have reported the beneficial effect of hyaluronidase in saving the complications of hyaluronic acid. However, the effects of hyaluronidase on dermal matrix, skin structure, and fibroblast function are unknown. METHOD: In this study, hyaluronic acid and hyaluronidase were injected… Read on PubMed →
Cross-Linked Sodium Hyaluronate Filler Containing Poly-L-Lactic Acid-b-Poly (Ethylene Glycol) Microspheres for Periorbital Rejuvenation: A Multimodal Assessment of Physicochemical, Preclinical, and Clinical Performance.
Journal of cosmetic dermatology · 2026
BACKGROUND: Periorbital rejuvenation presents significant challenges: hyaluronic acid (HA) fillers carry risks of edema and the Tyndall effect, whereas traditional poly-L-lactic acid (PLLA) may lead to nodule formation and delayed inflammatory reactions. To address these limitations, the PLLA-b-poly (ethylene glycol) (PLLA-b-PEG)/HA composite filler is designed to optimize tissue compatibility and… Read on PubMed →
The hyaluronan receptor CD44 drives COVID-19 severity through its regulation of neutrophil migration.
PLoS pathogens · 2026
The novel respiratory disease COVID-19 caused by the coronavirus SARS-CoV-2 continues to be a public health emergency worldwide, and there is a need for more effective therapy for patients. The relationship between the extracellular matrix and the host immune response to infection is severely understudied. Deposition of the polysaccharide hyaluronan (HA) into the lungs is associated with more… Read on PubMed →
Multifunctional hydrogels loaded with tannic acid-modified MXene for synergistic photothermal/pharmacological treatment of infected wounds caused by drug-resistant bacteria.
Biomaterials advances · 2026
The development of advanced dressings capable of integrating multiple therapeutic modalities represents a promising strategy for promoting the healing of complex infected wounds. Herein, we developed a multifunctional hydrogel dressing (OC-MT-AG) based on tannic acid-modified MXene (MT) and ampicillin/ glutamine (AG) for the synergistic treatment of drug-resistant bacterial-infected wounds. The… Read on PubMed →
Bioactive levan polysaccharides in cosmeceutical applications: A review.
International journal of biological macromolecules · 2026
Levan, a β-(2,6)-linked fructose homopolysaccharide, has gained increasing attention as a multifunctional biopolymer for cosmetic and cosmeceutical applications. Owing to its distinctive molecular architecture, levan uniquely combines high molecular weight, pronounced bioadhesive capacity, and remarkably low intrinsic viscosity, which facilitates its integration into diverse formulation platforms… Read on PubMed →
A multifunctional adhesive antibacterial chitosan/hyaluronic acid hydrogel enabling sustained release of human umbilical cord mesenchymal stem cell-derived exosomes for accelerated full-thickness skin repair.
International journal of biological macromolecules · 2026
Promoting skin wound healing is a major global public health challenge. Stem cell exosomes are regarded as a promising and ideal therapeutic approach. However, effective stem cell exosome therapy also depends on suitable vectors to promote the release and stability of exosomes. In this study, exosomes derived from human umbilical cord mesenchymal stem cells (UCMSCs-exo) were loaded into… Read on PubMed →
A review of biomacromolecular hydrogels inspired by regenerative organisms: Translating biological insights into tissue integration and regeneration.
International journal of biological macromolecules · 2026
Regenerative biology offers powerful insights into scarless healing and functional tissue integration, yet translating these biological principles into clinically effective biomaterials remains a major challenge. Biological macromolecule-based hydrogels, derived from natural proteins and polysaccharides, have emerged as promising platforms to bridge this gap due to their intrinsic bioactivity… Read on PubMed →
Safe and effective restoration of jawline definition with hyaluronic acid injectable gel: a systematic review and meta-analysis.
Acta dermatovenerologica Alpina, Pannonica, et Adriatica · 2026
A well-defined jawline is an important aspect of facial aesthetics, contributing to overall appearance. This feature is particularly sought after by individuals, especially older adults, who are interested in enhancing their facial contours. This systematic review and meta-analysis evaluates safety and effectiveness following use of VYC-25L, a hyaluronic acid-based injectable gel, for restoration… Read on PubMed →
Quantitative Assessment of Polydioxanone Microsphere Fillers for Nasolabial Fold Correction: A Comparative Study.
In vivo (Athens, Greece) · 2026
BACKGROUND/AIM: Dermal fillers are essential tools for facial rejuvenation. This study evaluated the clinical efficacy and safety of a polydioxanone (PDO)-based filler from UltraV, compared with established commercial alternatives for improving nasolabial fold wrinkles. MATERIALS AND METHODS: Thirty-one participants (aged 20-59 years) were enrolled in this prospective, split-face comparative… Read on PubMed →
Bioactive-Loaded Detachable Crosslinked Hyaluronic Acid Microneedles: Structural Validation and Clinical Anti-Wrinkle Efficacy.
Journal of biomedical materials research. Part A · 2026
Delivering a persistent biopolymer matrix to the superficial dermis remains a significant challenge for microneedle systems due to the inherent limitations of conventional dissolving platforms. Here, we present a detachable microneedle design that permits rapid needle separation during administration. To biologically compensate for the relatively short 350 μm needle geometry designed for at-home… Read on PubMed →
Choosing the Right Tewl Device: A Comparison of Inter- and Intra-Device Reliability of the Vapometer and Dermalab across Measurement Ranges.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026
BACKGROUND: Measurement of transepidermal water loss (TEWL) is widely used to evaluate skin barrier function. MATERIALS AND METHODS: This study compared two devices-the DermaLab (DL) TEWL probe and the VapoMeter (VM) - from data collected across three studies to measure TEWL in scarred and normal skin. Each site was measured three times per device, alternating devices to allow vapor clearance… Read on PubMed →
Efficacy of 1064-Nm Picosecond Nd: YAG Laser in Treating Facial Photoaging and Improving Skin Barrier Enhanced by a Multi-Beneficial Composition Formulation: A Blinded Randomized Clinical Trial Study.
Journal of cosmetic dermatology · 2026
BACKGROUND: In recent years, skin photoaging has received increasing attention, and laser therapy has become the most commonly used treatment due to its safety and efficacy; emerging evidence suggests that adjunctive "integrated skincare" may enhance treatment benefits by reducing post-procedural reactions and supporting skin barrier repair. OBJECTIVE: The split-face, double-blind, randomized… Read on PubMed →
Enhancement of Skin Barrier Function Using DYNAMiQ Technology: A Clinical Evaluation.
Journal of cosmetic dermatology · 2026
BACKGROUND: The integrity of the skin barrier is fundamental to maintaining overall skin health, serving as the primary defense against environmental insults. Disruption of this barrier is linked to various dermatological issues, including inflammation, sensitivity, and premature aging. Therefore, technologies designed to reinforce the skin barrier and enhance moisture retention hold a significant… Read on PubMed →
Forgotten Skin: What do our geriatric patch test findings reveal?
Allergologia et immunopathologia · 2026
Allergic contact dermatitis (ACD) in the elderly is influenced by age-related immunological changes, cumulative exposure, and skin barrier alterations. However, data comparing sensitization profiles among different geriatric populations remains limited. We aimed to evaluate and compare the patterns and severity of patch test reactions in patients aged 65-74 (young-old group) and those aged 75… Read on PubMed →
Dual function of TRPV4 in chronic dermatitis: Barrier protection counterbalanced by pruritic scratching.
Biochemical pharmacology · 2026
Chronic dermatitis represents a debilitating inflammatory skin disorder characterized by intense pruritus and significant epidermal barrier dysfunction that seriously deteriorates the quality of life of patients. Damage to the skin barrier plays a critical role in the development and progression of chronic dermatitis, while the expression of tight junction proteins is essential for maintaining… Read on PubMed →
Role of Extracellular Vesicles in Skin Barrier Repair: Applications in Atopic Dermatitis and Chronic Wounds.
International journal of nanomedicine · 2026
Extracellular vesicles (EVs) have emerged as a promising cell-free therapeutic strategy for skin barrier repair due to their ability to mediate intercellular communication through the delivery of bioactive cargo including proteins, lipids, and nucleic acids. This review synthesises current evidence on the role of EVs in restoring skin barrier integrity, with a particular focus on atopic dermatitis… Read on PubMed →
The lipid-inflammation axis in rosacea: mechanistic insights and therapeutic implications.
Frontiers in immunology · 2026
Rosacea is a chronic inflammatory skin disorder primarily characterized by persistent facial erythema, episodic flushing, papules and pustules, as well as phymatous changes. Despite extensive research, the pathogenesis of rosacea has not yet been fully elucidated. Current evidence suggests that rosacea develops on the basis of genetic susceptibility and results from the complex interplay of… Read on PubMed →
Pasteurized Akkermansia muciniphila HB05 improves ultraviolet B-induced skin dehydration and barrier dysfunction in SKH-1 hairless mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026
Ultraviolet B (UVB) radiation is a major environmental stressor that disrupts epidermal hydration, impairs barrier integrity, and accelerates photoaging through oxidative and inflammatory mechanisms. Although the metabolic and immunomodulatory benefits of Akkermansia muciniphila have been extensively investigated, its role in skin health remains largely unknown. In particular, the effects of… Read on PubMed →
Temporal transcriptional dynamics in cutaneous leishmaniasis reveal novel targets for therapeutic interventions in a dermal mouse model.
Frontiers in immunology · 2026
Cutaneous leishmaniasis (CL) caused by Leishmania braziliensis results in chronic skin ulceration and remains challenging to treat. While human transcriptomic studies have identified pathways driving immunopathology, the early events of infection and the molecular transitions from lesion formation to healing are still poorly understood. Here, we performed a longitudinal transcriptomic analysis of… Read on PubMed →