Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
374 papers
Novel 2-Phenyl-1H-Pyrrole Derivatives as Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss.
Chemical biology & drug design · 2026
Hair follicle stem cells (HFSCs) play the primary role in the regulation of the hair growth cycle. Premature termination of the anagen phase accelerates the transition of hair follicles into the catagen and telogen phases, leading to hair loss. Inhibiting the mitochondrial pyruvate carrier (MPC), which prevents pyruvate from entering mitochondria, enhances lactate synthesis. This activates HFSCs… Read on PubMed →
Case Report: Paradoxical psoriasis under TNF-α blockade may represent generalized abscessing staphyloderma - GASD syndrome by TNF antagonists.
Frontiers in immunology · 2026
Patients treated with TNF-α antagonists may develop psoriasis-like skin lesions. Clinical manifestations include palmoplantar, inverse, localized or generalized guttate, plaque-type, eczematous, and pustular lesions; deep inflammatory nodes; and nonscarring alopecia, often with overlapping reaction patterns. They are classified as paradoxical psoriasis and interpreted as an inflammatory reaction… Read on PubMed →
Molecular identification and pathogenicity confirmation of multi-azole resistant Malassezia species isolated from dandruff infected individuals prevailing in Mysuru, India.
Diagnostic microbiology and infectious disease · 2026
Worldwide distribution of dandruff associated scalp infections is caused by lipophilic Malassezia spp. This rationale lead the study to investigate the prevalence and etiologic species in a cross-sectional study involving 300 subjects who visited dermatology hospitals to seek treatment in K.R. Hospital, JSS Hospital and CSI Holdsworth Memorial Mission Hospital, Mysuru region, Karnataka, India… Read on PubMed →
Exploring the Skin Mycobiome: A Comparison of Skin Swabs and Tissue Specimens.
Aesthetic plastic surgery · 2026
Recent research has underscored the significant role of skin fungi in human health and disease. The advent of next-generation sequencing has facilitated the identification of previously unrecognized fungi; however, a standardized sampling method for the skin mycobiome has yet to be established. Given that fungi are distributed across all layers of the skin, this study aimed to establish and… Read on PubMed →
Decoding the Skin Micro-Immune Milieu, Homeostasis, and Keratinocyte Trafficking in Psoriatic Disease.
Immunological investigations · 2026
INTRODUCTION: The skin, acting as a complex interface between the immune system and microbiome, maintains balance through coordinated interactions among the epidermal barrier, microbiome, and immune responses. Psoriasis, a chronic autoimmune and inflammatory disorder, disrupts this balance by altering keratinocyte growth, immune signaling, and microbial diversity. RESULTS AND DISCUSSION: The… Read on PubMed →
Cupuaçu (Theobroma grandiflorum) butter nanoparticles associated with oligosaccharides as cosmetic carriers for prebiotic effect: development, physicochemical characterization, and preclinical evaluation.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2026
The skin microbiota is essential for cutaneous homeostasis, and prebiotics may support it. Nanostructured systems, such as cupuaçu-derived nanoparticles, enhance the delivery and stability of cosmetic active substances, but their role in modulating the skin microbiota remains unclear and requires targeted evaluation. In this study, lipid-polymeric hybrid nanoparticles based on cupuaçu (Theobroma… Read on PubMed →
Commensal yeast Malassezia produces tryptophan metabolites to promote tissue homeostasis via the aryl hydrocarbon receptor in mice.
Nature microbiology · 2026
As an abundant fungal colonizer of mammalian skin, Malassezia establishes mutualistic or pathogenic interactions with the host. Here we show that Malassezia furfur promotes skin homeostasis by maintaining epidermal integrity via tryptophan-derived metabolites that activate the aryl hydrocarbon receptor (AhR), a key regulator of keratinocyte differentiation and inflammation. M. furfur-derived… Read on PubMed →
Authors' Response to Comment on "When Genes Meet Gels: Computational Immunogenetics of Dermal Fillers and Stratified Risk of Immune and Fibrotic Reactions Across Compositions and Genotypes".
Aesthetic plastic surgery · 2026
We thank the correspondents for their thoughtful commentary on our recently published computational framework evaluating immune and fibrotic risk associated with dermal filler materials. We clarify that the proposed model was intentionally designed to generate relative, rank-based risk indices rather than absolute clinical event probabilities, a distinction explicitly acknowledged in the original… Read on PubMed →
Comparative Efficacy and Patient-centered Outcomes of Intraoral Submucosal Zonal Injection Versus Traditional Extra-oral Injection for Improving Perioral Contour: A Randomized Controlled Trial.
Aesthetic plastic surgery · 2026
BACKGROUND: Intraoral injection techniques have been reported in various countries, with their advantages well documented. Drawing upon existing literature on intraoral injections, we developed a novel intraoral submucosal zonal injection technique that has demonstrated promising therapeutic outcomes. However, its efficacy and safety require further validation through standardized clinical… Read on PubMed →
Guide for Managing Vascular Occlusion Due to Fillers with Extended Neuro-Ophthalmic Involvement: A Review of Diagnosis, Classification and Treatment.
Aesthetic plastic surgery · 2026
INTRODUCTION: Filler-induced ophthalmic vascular occlusion (FIVO) is rare but devastating, while stroke remains even less frequent. Hyaluronic acid (HA) accounts for most reported cases of blindness. Given the emergency nature of these events, rapid recognition and immediate preparedness are paramount. METHODS: A systematic search of PubMed, Web of Science, and the Cochrane Library was conducted… Read on PubMed →
Optimization of Non-Cross-Linked Hyaluronic Acid and Adipose-Derived Mesenchymal Stem Cells for Regenerative Applications: an in Vitro Study.
Cell biochemistry and biophysics · 2026
Hyaluronic acid (HA) and adipose-derived mesenchymal stem cells (AD-MSCs) are both promising agents for skin rejuvenation. Combining non-cross-linked HA with AD-MSCs may enhance regenerative outcomes; however, the optimal HA concentration and its compatibility with AD-MSCs remain unclear. This study evaluated AD-MSCs encapsulated in varying concentrations of non-cross-linked HA, including a… Read on PubMed →
Role of HYAL1 on hyaluronan metabolism and the regulation of epidermal tight junction component CLDN1 in HaCaT cells.
Archives of biochemistry and biophysics · 2026
Hyaluronan (HA), a polysaccharide present in tissues throughout the body, exhibits various physiological functions depending on its molecular weight. Although high-molecular-weight HA (HM-HA) is produced in large amounts in the epidermal basal layer, low-molecular-weight HA (LM-HA) exists and acts as a moisturizing factor in the epidermal stratum corneum. However, the mechanism and physiological… Read on PubMed →
Albendazole-loaded chitosan nanoparticle conjugated with hyaluronic acid for the treatment of psoriasis.
Drug development and industrial pharmacy · 2026
OBJECTIVE: To design and develop hyaluronic acid (HA) conjugated Albendazole (ABZ) loaded chitosan nanoparticles (HA-ABZ-CSNP) loaded hydrogel for the treatment of psoriasis. SIGNIFICANCE: Albendazole (ABZ), a commonly used anti-parasitic drug, has garnered a lot of attention lately including anticancer and anti-psoriasis properties. Chitosan nanoparticle followed by conjugation with HA was… Read on PubMed →
pH-gated dual-modal switch photothermal cascade nanozyme hydrogel for diabetic infectious wound healing.
Biomaterials advances · 2026
Diabetic wounds are affected by hyperglycemia and neurovascular complications, and are often further exacerbated by bacterial infections, hypoxia, and insufficient collagen deposition. To overcome these pathological barriers, we have designed a pH-gated nanozyme cascade catalytic strategy for rapid bacterial eradication and skin regeneration. In this study, we first synthesized Prussian blue… Read on PubMed →
Minimally Invasive Aesthetic Treatments for the Corrective Patient Archetype: Transforming Lives.
Aesthetic plastic surgery · 2026
BACKGROUND: The definition of health encompasses mental, emotional, and social well-being, rather than simply the absence of disease. As a result, corrective aesthetic treatments are increasingly being viewed as an integral component of overall health rather than confined solely to the domain of aesthetics. In the realm of facial aesthetics, the corrective patient archetype is distinctly focused… Read on PubMed →
Engineering fast-acting anti-itching multifunctional dressing with quercetin-CD-MOF for atopic dermatitis.
Biomaterials advances · 2026
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by susceptibility to infection and recurrent pruritus. Clinical treatment often focuses solely on skin lesions while neglecting direct control of pruritus symptoms. Herein, this study reports a novel powdered dressing (Que@CD@PH) that integrates in situ gelation, wet adhesion, and burst release of drugs for the treatment… Read on PubMed →
Preoperative Intravitreal Viscoelastic Injection (PIVOT) for Surgical Optimization in Rhegmatogenous Retinal Detachment With Choroidal Detachment.
Ophthalmic surgery, lasers & imaging retina · 2026
BACKGROUND AND OBJECTIVE: Rhegmatogenous retinal detachment with choroidal detachment (RRDCD) is a challenging situation. This study evaluates the safety and efficacy of preoperative intravitreal viscoelastic injection (PIVOT) in facilitating vitrectomy in RRD-CD. PATIENTS AND METHODS: This consecutive series included eight eyes of eight patients with RRD-CD (CD reaching to equator), managed… Read on PubMed →
Assessment of oxidative and inflammatory biomarkers in denture-related traumatic ulcers treated with different topical agents.
Archives of oral biology · 2026
OBJECTIVE: To investigate the potential role of oxidative and inflammatory status in saliva during the healing of denture-related traumatic ulcers, applying various topical agents. DESIGN: The prospective cohort study included 100 participants with denture-related traumatic ulcers, divided into five groups: traumatic ulcers that were not treated and treated with topical agents (0.2% hyaluronic… Read on PubMed →
Chitosan/hyaluronic acid-based hydrophobic-covalent double-network hydrogel: phenylalanine-mediated erythrocyte anchoring for rapid hemostasis, anti-swelling, and antioxidation.
International journal of biological macromolecules · 2026
This study addresses critical limitations of conventional hemostatic materials-such as significant swelling and inadequate adhesion to wet tissues-by developing an injectable and photocurable hydrogel (OPP-HAMA). The hydrogel is constructed through a rational molecular design: phenylalanine is grafted onto an oxidized chitosan backbone via a Schiff base reaction, thereby introducing hydrophobic… Read on PubMed →
Hyaluronic Acid Dermal Filler-Associated Vascular Occlusion-A Review of Prevention and Management Strategies.
Journal of cosmetic dermatology · 2026
BACKGROUND: Significant complications are uncommon with aesthetic hyaluronic acid (HA) dermal fillers, but inadvertent injection of dermal filler into an artery can result in tissue damage, scarring, visual loss, and even stroke. Practitioners must therefore reduce this risk through proactive, preventative techniques. Early recognition of vascular occlusion (VO) is also crucial to minimize… Read on PubMed →