Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
374 papers
Patient-specific 3D-printed scaffold for pediatric superior sternal cleft repair.
Journal of cardiothoracic surgery · 2026
RATIONALE: Sternal cleft is a rare congenital chest wall defect resulting from failed fusion of the sternal bars during embryogenesis. Primary closure is often feasible in the neonatal period due to thoracic wall compliance, but delayed presentations require complex reconstruction using autologous tissues, muscle flaps, and/or biomaterials. PATIENT CONCERNS: A two-year-old male presented with a… Read on PubMed →
Comparative effectiveness of acupuncture, fire needle, and herbal therapies for melasma: A Bayesian network meta-analysis.
Medicine · 2026
BACKGROUND: Melasma is a prevalent pigmentary disorder among reproductive-age Asian women. Although various treatment modalities exist, most demonstrate limited efficacy and carry the risk of adverse effects. In recent years, external Traditional Chinese Medicine (TCM) therapies (including acupuncture, fire needle, and herbal external applications) have attracted increasing attention as… Read on PubMed →
A systematic review of clinical evidence on the efficacy and safety of conditioned media, platelet-rich fibrin, stromal vascular fraction, extracellular vesicles, and stem cells in androgenetic alopecia.
Stem cell research & therapy · 2026
AIMS AND OBJECTIVES: Androgenetic alopecia (AGA) is a common progressive hair loss disorder caused by follicular miniaturization and shortened anagen phases. Conventional treatments mainly target androgen pathways but often yield unsatisfactory results. Regenerative medicine has emerged as a novel therapeutic approach aiming to restore follicular function through biologically active cell-based or… Read on PubMed →
Assessment of the efficiency of new regenerative gel and spray in experimental model systems.
BMC pharmacology & toxicology · 2026
INTRODUCTION: The problem of wound healing and the availability of effective and safe agents with regenerative properties is critically important today. The aim of the study was to develop an algorithm for evaluating products with regenerative potential using a set of in vitro and in vivo experimental models. METHODS: In vitro research included methods of working with cell culture. Studies were… Read on PubMed →
Demonstration of Gliadin Penetration into the Epidermis by Tape Stripping as Prerequisite for Percutaneous Sensitisation in Wheat Allergy.
International journal of molecular sciences · 2026
Sensitisation leading to food allergy may occur through the skin. Quantitative data on epidermal allergen penetration as a prerequisite for this remain limited. This study quantifies epidermal penetration of gluten and hydrolysed wheat protein (HWP) in 18 patients with challenge-confirmed WALDA (wheat allergy dependent on augmentation factors) and 12 healthy controls (HC). After 1 h of… Read on PubMed →
Fact-Checking Large Language Model Responses to a Health Care Prompt: Comparative Study.
JMIR formative research · 2026
BACKGROUND: Large language models use machine learning to produce natural language. These models have a range of potential applications in health care, such as patient education and diagnosis. However, evaluations of large language models in health care are still scarce. OBJECTIVE: This study aimed to (1) evaluate the accuracy and efficiency of automated fact-checking by 2 large language models… Read on PubMed →
Inhibiting LSD1 unlocks retinoid AP-1 programming to activate epithelial immunity and skin tumor suppression.
The Journal of clinical investigation · 2026
Lysine-specific demethylase 1 (LSD1; KDM1A) orchestrates context-dependent chromatin programs, yet its role in epithelial immunity remains largely unknown. Here, we identify LSD1 as a central brake on retinoid-driven and activator protein-1-driven (AP-1-driven) enhancer activation in epidermis and demonstrate that its inhibition induces antitumor immunity. Whereas epidermal LSD1 is required during… Read on PubMed →
A novel cell-penetrating peptide supports hair follicle growth through anti-inflammatory and growth factor-associated mechanisms in preclinical models.
BMC biotechnology · 2026
BACKGROUND: Hair loss remains a prevalent condition for both men and women worldwide. Current therapies for this condition, including minoxidil and finasteride, are limited by inconsistent efficacy, side effects, and dependence on continuous use. Cell-penetrating peptides (CPPs) have emerged as promising bioactive agents in dermatology due to their ability to traverse cell membranes and modulate… Read on PubMed →
Dissolvable Microneedle Arrays Loaded with SCH772984 Targeting the MAPK/ERK Pathway to Inhibit Abnormal Vascular Proliferation in Hypertrophic Scars.
ACS biomaterials science & engineering · 2026
BACKGROUND: pathological angiogenesis is a critical driver of hypertrophic scar (HS) formation, a common fibrotic skin disorder with limited therapeutic options. However, the precise molecular pathways governing scar-associated neovascularization remain incompletely understood. This study aims to develop a biomaterial-based targeted delivery system to inhibit angiogenesis-driven HS… Read on PubMed →
Facial laser complications (A Five Year Review).
Lasers in medical science · 2026
Lasers have become integral to dermatology and plastic surgery, with expanding applications for skin rejuvenation, scar revision, and pigmentary disorders. Despite technological advances, complications remain a significant concern, particularly in patients with darker skin types. A systematic review was performed following PRISMA 2020 guidelines. PubMed, Embase, and Scopus were searched for… Read on PubMed →
A global score for skin environmental exposure: integrating UV radiation, heat, and pollution via fuzzy analytic hierarchy process.
International journal of biometeorology · 2026
Environmental stressors such as ultraviolet radiation (UVR), air pollutants, and thermal stress interact synergistically to accelerate skin damage, yet most available indicators still assess these factors in isolation. The Skin Environmental Exposure Score (SEES) is a new and innovative fuzzy logic-based tool that integrates UVR, heat, ozone, and particulate matter into a single 0-1000 score… Read on PubMed →
Piceatannol from Passion Fruit Seed Waste: A Circular Bioeconomy-Driven Pathway Toward a Skin-Targeted Bioactive.
International journal of molecular sciences · 2026
Passiflora edulis (passion fruit) seed waste, an abundant by-product of the juice industry, is a promising source of piceatannol (PIC), a hydroxystilbene with superior antioxidant activity compared to resveratrol. However, its translation into a skin-targeted ingredient remains hindered by a lack of standardization and clinical validation. This review synthesizes current evidence on the… Read on PubMed →
Chemical Characteristics and Antimicrobial Activity of Arctostaphylos uva-ursi (L.) Spreng. Extracts Against Skin-Associated Bacteria.
Molecules (Basel, Switzerland) · 2026
The interest in the use of phytochemicals and herbal medicines for the treatment of acne vulgaris has grown steadily over recent decades. The research on the secondary metabolites and biological properties of bearberry (Arctostaphylos uva-ursi (L.) Spreng.) has been intensified in recent years, but the range of bacterial strains tested, many of which are highly relevant to human health, remains… Read on PubMed →
Efficacy and safety of e.p.t.q. hyaluronic acid fillers in the context of aesthetic facial rejuvenation or beautification: a post-market clinical follow-up study.
Scientific reports · 2026
This study was conducted to assess the efficacy and safety of e.p.t.q. hyaluronic acid (HA) fillers (JETEMA Co., Ltd., Yongin, Korea) in the context of aesthetic facial rejuvenation or beautification. The patients were evaluated for changes in the Wrinkle Severity Rating Scale (WSRS) scores, the Mid-Face Volume Deficit Scale (MFVDS) scores and the Medicis Lip Fullness Scale (MLFS) scores at 24… Read on PubMed →
Photoprotective Potential of a Yeast/Rice Fermentation Filtrate and Sialic Acid in Mitigating UVA-Induced Oxidative Stress and Mitochondrial Dysfunction in Skin Fibroblasts.
Molecules (Basel, Switzerland) · 2026
Ultraviolet A (UVA) radiation induces oxidative stress and mitochondrial dysfunction in dermal fibroblasts, contributing to photodamage and skin aging. This study investigated the protective effects of Yeast/rice fermentation filtrate (RFF) and sialic acid (SA), both individually and in combination, against UVA-induced damage in human dermal fibroblasts. Cell viability, reactive oxygen species… Read on PubMed →
Metabolic adaptation drives self-organization during skin organoid morphogenesis.
Nature communications · 2026
Self-organization in organoid morphogenesis involves the coordinated arrangement of interacting cells into higher-order structures, yet the underlying principles remain elusive. Here, we investigate how epidermal and dermal cells respond distinctively to elevated levels of hypoxia during skin organoid morphogenesis that largely resembles the skin development during embryogenesis. We unveil that… Read on PubMed →
Evaluation of the Antimicrobial Potential of Malaysian Kelulut Honeydew Honey Against Acne Pathogens.
Current microbiology · 2026
Acne is the eighth most prevalent chronic skin disease globally. The increased emergence of antibiotic resistance and chemical-induced side effects make acne treatments challenging. Hence, a natural remedy, Malaysian Kelulut honeydew honey, was proposed in this research due to its beneficial properties and the absence of antibiotic resistance. An in vitro efficacy of honey was evaluated against… Read on PubMed →
Ethanolic Extract of Padina arborescens Suppresses Melanogenesis and Attenuates UVB-Induced Photodamage in Cellular and Zebrafish Models.
International journal of molecular sciences · 2026
Ultraviolet (UV) irradiation induces complex skin damage, including hyperpigmentation, oxidative stress, and alterations in proteins related to keratinocyte differentiation and epidermal barrier-associated status. This study investigated the multifunctional protective effects of Padina arborescens ethanolic extract (PAEE) against skin damage in melanocytes, keratinocytes, and zebrafish. In… Read on PubMed →
Efficacy and safety of topical finasteride spray solution in the treatment of Chinese men with androgenetic alopecia: A phase III, multicenter, randomized, double-blind, placebo-controlled study.
Chinese medical journal · 2026
BACKGROUND: Topical finasteride is a novel treatment for men with androgenetic alopecia (AGA). This study aimed to evaluate the efficacy and safety of topical finasteride spray solution in Chinese men with AGA. METHODS: This randomized, double-blind, placebo-controlled, phase III trial enrolled 270 individuals with AGA from 16 sites across China between December 2021 and March 2023. The… Read on PubMed →
Retinoic acid at the crossroads of reproduction and sleep: an underexplored link with clinical implications.
Reproduction (Cambridge, England) · 2026
Retinoic acid, a vitamin A derivative widely used in dermatology, plays essential roles in female and male reproductive physiology and in the regulation of circadian rhythms. Emerging evidence suggests that chronic exposure to systemic retinoids, such as isotretinoin, may influence fertility parameters and sleep-reproductive interactions, highlighting the need for greater clinical awareness and… Read on PubMed →