Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
49 papers under Skin barrier
Estimating Transepidermal Water Loss from Smartphone Facial Images Using Self-Supervised Features and a Mixture Density Network.
Studies in health technology and informatics · 2026
Skin conditions fluctuate daily, and the subtle changes are difficult to detect. Transepidermal water loss (TEWL), a key indicator of skin barrier function, is effective for monitoring these changes; however, its measurement requires specialized and costly equipment, making daily implementation impractical. This study aimed to develop and evaluate a machine-learning model for estimating TEWL from… Read on PubMed →
Konjac Ceramide Induces Semaphorin 3A Expression via the MAPK/AP-1 Signaling Axis and RORα in Normal Human Epidermal Keratinocytes.
Biomolecules · 2026
Epidermal hyperinnervation is a major cause of intractable itch in barrier dysfunction conditions such as atopic dermatitis. Keratinocyte-derived semaphorin 3A (Sema3A) suppresses epidermal hyperinnervation, but its expression is markedly reduced in barrier-disrupted skin. Although konjac ceramide (kCer) has been reported to act as a Sema3A-like ligand, the mechanisms by which it regulates Sema3A… Read on PubMed →
Understanding Infantile Atopic Dermatitis: A Review of Environmental, Familial, Genetic and Microbial Influences.
Current allergy and asthma reports · 2026
PURPOSE OF REVIEW: This review aims to clarify the early-life risk and protective factors associated with Infantile Atopic Dermatitis (IAD)-an inflammatory skin condition that typically develops between birth and two years of age. The goal was to examine recent findings on maternal, environmental, and microbial influences on IAD. RECENT FINDINGS: Prenatal and postpartum maternal probiotic use may… Read on PubMed →
The Protective and Regenerative Potential of Lactoferrin in Hair and Skin Health.
International journal of molecular sciences · 2026
Lactoferrin is a naturally occurring bioactive glycoprotein that is part of the body's innate immune system and has essential roles in iron metabolism, microbial defense, inflammation regulation, and tissue repair. It supports the natural regulation of iron bioavailability in skin and hair follicles, helping to reduce excess free-iron-driven oxidative stress while preserving levels of necessary… Read on PubMed →
A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women.
Nutrients · 2026
BACKGROUND: Centella asiatica has been widely recognized for its dermatological benefits; however, clinical evidence supporting the efficacy of oral supplementation for improving skin aging parameters remains limited. This randomized, double-blind, placebo-controlled study evaluated the effects of oral Centella asiatica extract on skin wrinkles and related skin parameters in middle-aged… Read on PubMed →
Advances in Gentle Polymeric Cleansing Technologies.
Journal of drugs in dermatology : JDD · 2026
Modern skin cleansers have evolved from basic soaps to advanced cleansing formulations that also provide moisturization and skin barrier support. Surfactants work by emulsifying oils and reducing surface tension, but they may disrupt essential lipids in the skin, leading to barrier damage and sensitivity. Advances in surfactant technology have enabled the development of cleansers that combine… Read on PubMed →
Clinical and Mechanistic Evidence for Comano Thermal Water: A Narrative Review.
International journal of molecular sciences · 2026
Comano thermal water (CTW) is a hypotonic, bicarbonate-calcium-magnesium mineral water traditionally used to manage chronic inflammatory and relapsing skin diseases. This review summarises and discusses the available clinical, experimental, and translational evidence on CTW, with a particular focus on dermatological indications. The physicochemical properties of CTW, along with the presence of a… Read on PubMed →
Demonstration of Gliadin Penetration into the Epidermis by Tape Stripping as Prerequisite for Percutaneous Sensitisation in Wheat Allergy.
International journal of molecular sciences · 2026
Sensitisation leading to food allergy may occur through the skin. Quantitative data on epidermal allergen penetration as a prerequisite for this remain limited. This study quantifies epidermal penetration of gluten and hydrolysed wheat protein (HWP) in 18 patients with challenge-confirmed WALDA (wheat allergy dependent on augmentation factors) and 12 healthy controls (HC). After 1 h of… Read on PubMed →
Choosing the Right Tewl Device: A Comparison of Inter- and Intra-Device Reliability of the Vapometer and Dermalab across Measurement Ranges.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026
BACKGROUND: Measurement of transepidermal water loss (TEWL) is widely used to evaluate skin barrier function. MATERIALS AND METHODS: This study compared two devices-the DermaLab (DL) TEWL probe and the VapoMeter (VM) - from data collected across three studies to measure TEWL in scarred and normal skin. Each site was measured three times per device, alternating devices to allow vapor clearance… Read on PubMed →
Efficacy of 1064-Nm Picosecond Nd: YAG Laser in Treating Facial Photoaging and Improving Skin Barrier Enhanced by a Multi-Beneficial Composition Formulation: A Blinded Randomized Clinical Trial Study.
Journal of cosmetic dermatology · 2026
BACKGROUND: In recent years, skin photoaging has received increasing attention, and laser therapy has become the most commonly used treatment due to its safety and efficacy; emerging evidence suggests that adjunctive "integrated skincare" may enhance treatment benefits by reducing post-procedural reactions and supporting skin barrier repair. OBJECTIVE: The split-face, double-blind, randomized… Read on PubMed →
Enhancement of Skin Barrier Function Using DYNAMiQ Technology: A Clinical Evaluation.
Journal of cosmetic dermatology · 2026
BACKGROUND: The integrity of the skin barrier is fundamental to maintaining overall skin health, serving as the primary defense against environmental insults. Disruption of this barrier is linked to various dermatological issues, including inflammation, sensitivity, and premature aging. Therefore, technologies designed to reinforce the skin barrier and enhance moisture retention hold a significant… Read on PubMed →
Forgotten Skin: What do our geriatric patch test findings reveal?
Allergologia et immunopathologia · 2026
Allergic contact dermatitis (ACD) in the elderly is influenced by age-related immunological changes, cumulative exposure, and skin barrier alterations. However, data comparing sensitization profiles among different geriatric populations remains limited. We aimed to evaluate and compare the patterns and severity of patch test reactions in patients aged 65-74 (young-old group) and those aged 75… Read on PubMed →
Dual function of TRPV4 in chronic dermatitis: Barrier protection counterbalanced by pruritic scratching.
Biochemical pharmacology · 2026
Chronic dermatitis represents a debilitating inflammatory skin disorder characterized by intense pruritus and significant epidermal barrier dysfunction that seriously deteriorates the quality of life of patients. Damage to the skin barrier plays a critical role in the development and progression of chronic dermatitis, while the expression of tight junction proteins is essential for maintaining… Read on PubMed →
Role of Extracellular Vesicles in Skin Barrier Repair: Applications in Atopic Dermatitis and Chronic Wounds.
International journal of nanomedicine · 2026
Extracellular vesicles (EVs) have emerged as a promising cell-free therapeutic strategy for skin barrier repair due to their ability to mediate intercellular communication through the delivery of bioactive cargo including proteins, lipids, and nucleic acids. This review synthesises current evidence on the role of EVs in restoring skin barrier integrity, with a particular focus on atopic dermatitis… Read on PubMed →
The lipid-inflammation axis in rosacea: mechanistic insights and therapeutic implications.
Frontiers in immunology · 2026
Rosacea is a chronic inflammatory skin disorder primarily characterized by persistent facial erythema, episodic flushing, papules and pustules, as well as phymatous changes. Despite extensive research, the pathogenesis of rosacea has not yet been fully elucidated. Current evidence suggests that rosacea develops on the basis of genetic susceptibility and results from the complex interplay of… Read on PubMed →
Pasteurized Akkermansia muciniphila HB05 improves ultraviolet B-induced skin dehydration and barrier dysfunction in SKH-1 hairless mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026
Ultraviolet B (UVB) radiation is a major environmental stressor that disrupts epidermal hydration, impairs barrier integrity, and accelerates photoaging through oxidative and inflammatory mechanisms. Although the metabolic and immunomodulatory benefits of Akkermansia muciniphila have been extensively investigated, its role in skin health remains largely unknown. In particular, the effects of… Read on PubMed →
Temporal transcriptional dynamics in cutaneous leishmaniasis reveal novel targets for therapeutic interventions in a dermal mouse model.
Frontiers in immunology · 2026
Cutaneous leishmaniasis (CL) caused by Leishmania braziliensis results in chronic skin ulceration and remains challenging to treat. While human transcriptomic studies have identified pathways driving immunopathology, the early events of infection and the molecular transitions from lesion formation to healing are still poorly understood. Here, we performed a longitudinal transcriptomic analysis of… Read on PubMed →
Beyond T helper 2 cells: Integrating immune, barrier, microbial, and neuroimmune pathways in atopic dermatitis pathogenesis.
Journal of the American Academy of Dermatology · 2026
Atopic dermatitis is a heterogeneous inflammatory skin disease long-defined by skin barrier dysfunction and type 2 (T helper cell [Th]2) immune dysregulation. Dupilumab established interleukin (IL)-4 and IL-13 as key therapeutic targets, yet partial response rates underscore contributions from Th1, Th17, Th22, and other pathways that vary by age, ethnicity, and disease stage. Cytokine signaling… Read on PubMed →
Basic skin care for atopic dermatitis.
Journal of the American Academy of Dermatology · 2026
Basic skin care for atopic dermatitis (AD) management may impact the skin barrier, pruritus, and skin inflammation. Moisturizers and appropriate bathing practices are recommended for all patients with AD, regardless of disease severity. Wet-wrap therapy is typically reserved for patients with moderate-to-severe AD to control flares or manage recalcitrant disease. Although high-quality evidence… Read on PubMed →
Research hotspots and emerging frontiers in photodynamic therapy for basal cell carcinoma: A global bibliometric analysis (2001-2025).
Photodiagnosis and photodynamic therapy · 2026
BACKGROUND: Basal cell carcinoma (BCC) is the most prevalent cutaneous malignancy. It correlates strongly with ultraviolet exposure. The incidence of BCC continues to climb annually. Consequently, the demand for safe, cosmetically favorable, and highly effective therapies is pressing. Photodynamic therapy (PDT) has captured significant research interest due to its therapeutic efficacy against BCC… Read on PubMed →