Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
49 papers under Skin barrier
Dandruff Is a Low-Grade Inflammatory Condition Featuring Hyperproliferative Keratinocytes, Interleukin-17-Producing T Cells, and N-Acyl Ethanolamines.
Immunity, inflammation and disease · 2026
BACKGROUND: Dandruff features epidermal scaling but lacks overt signs of inflammation, such as erythema. Characterisation of its inflammatory profile may improve understanding of the underlying inflammatory mechanisms and therefore indicate alternative approaches for treatment. METHODS: Full-thickness scalp biopsies were sampled from healthy volunteers and those with dandruff… Read on PubMed →
Gut microbiota and the kidney-gut-skin axis in chronic kidney disease-associated pruritus: mechanisms and therapeutic implications.
Frontiers in cellular and infection microbiology · 2026
Chronic kidney disease-associated pruritus (CKD-aP) is a highly prevalent and debilitating symptom in patients with chronic kidney disease (CKD) and end-stage kidney disease (ESKD), severely impairing quality of life, sleep quality, mental health, and clinical outcomes. Its pathogenesis is multifactorial and remains incompletely understood, involving chronic inflammation, immune imbalance… Read on PubMed →
Extracellular vesicles in atopic dermatitis: unraveling pathogenic mediators and engineering therapeutic vectors.
Frontiers in immunology · 2026
Atopic dermatitis (AD) is a complex chronic inflammatory skin disease whose pathogenesis involves a vicious cycle of epidermal barrier defects, immune dysregulation, and microbial imbalance. Despite advances in targeted biologics and small-molecule drugs, there remains an unmet clinical need for safe, effective treatments that can simultaneously intervene in multiple pathological processes… Read on PubMed →
Dual targeting of cutaneous inflammation and vasculopathy via STING-NF-κB blockade underlies the anti-psoriatic efficacy of Yinxie Granules.
Chinese journal of natural medicines · 2026
Psoriasis is a chronic skin disease driven by skin inflammation and abnormal subcutaneous blood vessels. Yinxie Granules (YXKL) is a clinically effective traditional Chinese medicine (TCM) formula that has shown promise in psoriasis treatment, but its pharmacological mechanisms and material basis remain unclear, limiting its clinical application and co-administration with other drugs. In this… Read on PubMed →
Noninvasive Diagnosis Revealed a Strong Therapeutic Response and Skin Barrier Changes in Hemoporfin-Mediated Photodynamic Therapy for Port-Wine Stains.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026
BACKGROUND: Noninvasive skin imaging, such as reflectance confocal microscopy (RCM) and optical coherence tomography (OCT), has been extensively used to collect objective clinical data and assess the morphological and ultrastructural change of tissue. However, the application of these noninvasive diagnosis techniques for the therapeutic evaluation of hemoporfin-mediated photodynamic therapy… Read on PubMed →
Carvotanacetone from Saposhnikoviae radix restores skin barrier by regulating SP1 and Claudin-1.
General physiology and biophysics · 2026
This study aimed to investigate how Saposhnikoviae radix regulates skin barrier function. Bioinformatics analysis was conducted to identify the compounds in Saposhnikoviae radix and their target genes related to cell barrier function. Molecular docking analysis was performed to investigate the interaction between carvotanacetone (CARV) and key genes. The impact of CARV on skin barrier function was… Read on PubMed →
Effects of Selective Sphingosine-1-Phosphate Receptor 1 Agonist, TRV045, on Evoked Pain Tests: An Exploratory, Four-Way Cross-Over Study in Healthy Volunteers.
European journal of pain (London, England) · 2026
INTRODUCTION: Preclinical evidence suggests that dysregulation of the ceramide-sphingosine-1-phosphate (S1P) axis may have analgesic properties. However, currently approved S1PR1 modulators such as fingolimod are hindered for this indication as they induce lymphopenia. The aim of the current study was to evaluate whether the novel, selective S1PR1 agonist TRV045 has analgesic effects in a… Read on PubMed →
The Toxin of the Year: Airborne PM2.5.
Dermatitis : contact, atopic, occupational, drug · 2026
Particulate matter (PM) with a diameter of 2.5 µm or smaller (PM2.5) has emerged as a critical environmental toxin affecting skin health. In light of its widespread and often underestimated impact, we designated PM2.5 as the "toxin of the year." Although PM2.5 primarily affects the respiratory system, growing evidence indicates that it also plays a significant role in cutaneous health. Exposure to… Read on PubMed →
Alpinia zerumbet-Derived Extracellular Vesicles Protect Against UVB-Induced Photoaging by Enhancing Mitochondrial Bioenergetics and Skin Barrier Function.
BioFactors (Oxford, England) · 2026
Ultraviolet B (UVB) radiation is a major cause of skin photoaging by oxidative stress, mitochondrial dysfunction, and barrier disruption. Plant-derived extracellular vesicles (PDEVs) have emerged as promising bioactive nanocarriers, but their roles in mitochondrial regulation and skin barrier homeostasis remain unclear. This study aimed to investigate the protective effects of extracellular… Read on PubMed →