Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
47 papers under Melasma & dark spots
Adrenocortical Carcinoma in Peutz-Jeghers Syndrome With a Rare STK11 Pathogenic Germline Variant: A Case Report.
Cancer reports (Hoboken, N.J.) · 2026
BACKGROUND: Peutz-Jeghers syndrome (PJS) is an inherited, autosomal-dominant condition, featuring STK11 germline mutations, characterized by hamartomatous gastrointestinal polyps and increased cancer risk. The most commonly associated malignancies are gastrointestinal, pancreatic, and breast cancers. Herein, we report an extremely rare case of PJS with adrenocortical carcinoma (ACC). CASE: A… Read on PubMed →
Thoracic Botox Injections for Refractory Notalgia Paresthetica.
Pain medicine case reports · 2026
BACKGROUND: Notalgia paresthetica is a chronic neuropathic pruritus at the thoracic interscapular and paravertebral region. CASE REPORT: A 30-year-old man with a history of diabetes presented to the clinic with left periscapular pain. The patient had chronic, burning, pruritic pain localized to the left mid-thoracic paraspinal region and a well-demarcated hyperpigmentation over the affected area… Read on PubMed →
Exploring the mechanism of differential responses to combination therapy in melasma: pigmentary versus mixed pigmentary-vascular types-a clinical study based on interaction analysis.
The Journal of dermatological treatment · 2026
BACKGROUND: Melasma shows clinical heterogeneity, but the role of vascular components in treatment resistance remains unclear. METHODS: This retrospective cohort study included 75 melasma patients stratified by severity (mild/moderate/severe, n = 25 each) and classified into pure pigmentary (M-type, n = 42) and mixed pigmentary-vascular (M + V-type, n = 33). All received low-fluence Q-switched… Read on PubMed →
A Case Report: Treatment, follow-up, and literature review of type A insulin resistance syndrome caused by a De Novo INSR c.3328G>C mutation.
Frontiers in endocrinology · 2026
BACKGROUND: Type A insulin resistance syndrome (TAIRS) is a rare inherited disorder caused by mutations in the insulin receptor (INSR) gene. It is characterized by severe insulin resistance, hyperandrogenism, and acanthosis nigricans. Its clinical manifestations overlap with those of polycystic ovary syndrome (PCOS), making it prone to misdiagnosis, particularly in adolescent females. Currently… Read on PubMed →
Lasers for Melasma.
Dermatologic clinics · 2026
Melasma is a chronic pigmentary condition with a multifactorial pathophysiology, involving melanin overproduction, photoaging, and hormonal factors, making treatment challenging. Lasers and light-based devices, including intense pulsed light, photobiomodulation, Q-Switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser, nanosecond laser, picosecond laser, nonablative fractional laser and… Read on PubMed →
Fading the spots: a pilot case series of partial unilateral lentiginosis treated with Q-switched Nd: YAG laser.
Annals of medicine · 2026
INTRODUCTION: Partial unilateral lentiginosis (PUL) is rare pigmentary disorder characterized by clusters of unilateral lentiginous macules that can cause significant cosmetic and psychosocial distress. Despite its benign nature, there is no established standard treatment, and existing options often yield inconsistent results. This pilot case series evaluated the efficacy and safety of the… Read on PubMed →
Platelet-Rich Plasma and Platelet-Rich Fibrin in Periorbital Esthetics: Systematic Review and Clinical Applications.
Facial plastic surgery clinics of North America · 2026
This systematic review evaluates the effectiveness of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) for periorbital rejuvenation, updating a previous 2021 review. Twenty-six studies were included with notable variability in preparation methods limiting clear conclusions. Patient satisfaction was high with PRP/PRF treatment, which was only moderately effective for periorbital… Read on PubMed →