Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
49 papers under Retinoids
Retinoic Acid Signaling Alters the Balance of Epidermal Stem Cell Populations in the Skin.
The Journal of investigative dermatology · 2026
All-trans retinoic acid, the active form of retinoid, is a potent antiaging and anti-inflammatory agent with pleiotropic effects on various skin conditions. In the interfollicular epidermis, tissue turnover is maintained by heterogeneous epidermal stem cell populations located at the basal layer. Mouse tail skin contains slow- and fast-cycling epidermal stem cell populations. The reduction of… Read on PubMed →
Antifungal Monotherapy in Acne: Topical Ketoconazole 2% Cream Versus Adapalene Gel in Treating Acne Vulgaris: A Comparative Study.
Journal of cutaneous medicine and surgery · 2026
BACKGROUND: Acne is a widely prevalent disorder, with a largely negative impact on the patient's quality of life. Bacterial etiology and the role of Cutibacterium acne have always been incriminated in in acne pathogenesis. However, in the last decade, deeper understanding of skin microbiome postulates a possible role of other pathogens like Malassezia spp. ketoconazole has shown efficacy to both… Read on PubMed →
Clinical Characteristics and Treatment Patterns of Psoriasis in Asia and Switzerland: Results of the Multicentre Global Healthcare Study on Psoriasis (GHSP).
International journal of dermatology · 2026
BACKGROUND: Psoriasis is a chronic inflammatory skin and systemic disease with a wide range of clinical manifestations and treatment options, including topicals, phototherapy, non-biologic systemic treatments, and biologics. Understanding regional differences in clinical characteristics and treatment patterns can help improve equity and access to care globally. METHODS: The Global Healthcare… Read on PubMed →
Update on cutaneous lupus erythematosus pathogenesis, diagnosis and management.
Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
Cutaneous lupus erythematosus (CLE) encompasses a spectrum of skin manifestations that may occur as an isolated dermatological condition or in association with systemic lupus erythematosus (SLE). This review provides an updated synthesis of current knowledge on CLE, including its classification, pathogenesis, clinical presentation and diagnostic strategy. It will discuss recent advances in… Read on PubMed →
Connectivity mapping with isotretinoin's transcriptomic signature identifies alternative therapeutics for severe acne.
The Journal of investigative dermatology · 2026
Isotretinoin, the gold-standard treatment for severe acne, effectively targets major pathogenic factors but carries teratogenic risks. Its precise mechanism of action remains incompletely understood. Computational approaches, such as connectivity mapping, can offer insights into a drug's mechanism and identify alternative compounds as potential novel therapeutics for acne. In this study, we… Read on PubMed →
Clinical and Molecular Perspectives on Epidermodysplasia Verruciformis.
International journal of dermatology · 2026
Epidermodysplasia verruciformis (EV) is a rare dermatologic disorder marked by an increased susceptibility to β-human papillomavirus infections and a heightened risk of cutaneous squamous cell carcinoma. While classically associated with autosomal recessive pathogenic variants in TMC6, TMC8, and CIB1, recent reports have expanded the disease spectrum to include acquired forms occurring in… Read on PubMed →
Racial Differences in Dermatologic Treatment for Adolescents With PCOS-Related Acne Vulgaris.
Pediatric dermatology · 2026
BACKGROUND/OBJECTIVES: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women, with acne frequently appearing during adolescence. Racial and ethnic disparities in PCOS phenotype and adult acne treatment are well documented, yet differences in acne management among adolescents with PCOS remain unclear. This study evaluated racial and ethnic differences in acne treatment patterns… Read on PubMed →
Antioxidant regulatory mechanisms of retinoic acid and its therapeutic potential in oxidative stress-related diseases.
Biochemical pharmacology · 2026
As a metabolite of vitamin A, retinoic acid (RA) is bound to nuclear receptors (RAR/RXR) to produce effects and regulate gene expression, showing antioxidant, anti-inflammatory, and anti-apoptotic activities [1]. Oxidative stress, induced by both endogenous and exogenous factors, results in the excessive accumulation of reactive oxygen species (ROS) in specific areas, which can damage cellular… Read on PubMed →
Acantholytic disorders: Update on pathophysiology, diagnosis, and management.
Journal of the American Academy of Dermatology · 2026
Acantholytic skin disorders without a primary immunological etiology are characterized by impaired intercellular adhesion between epidermal keratinocytes. Genetic acantholytic disorders include Darier disease and Hailey-Hailey disease; the pathogenesis of Grover disease is unknown. Since these conditions are not commonly seen in clinical practice, diagnoses may be missed and there are no… Read on PubMed →
New Eruption of Bullous Pemphigoid Within Disseminated Superficial Porokeratosis Lesions: A Rare Case Report.
The Australasian journal of dermatology · 2026
In 2024, a 75-year-old Chinese man presented with a complex dermatological case involving features of both disseminated superficial porokeratosis (DSP) and bullous pemphigoid (BP). The patient exhibited a long-standing history of pruritic annular brownish plaques with hyperkeratotic borders, alongside recent blistering eruptions on his hands, feet and trunk. Diagnostic investigations revealed… Read on PubMed →
Benign Keratoses With Inverted Follicular Keratosis-Like Features in a Patient Receiving Ripretinib: A Case Report.
Journal of cutaneous pathology · 2026
Inverted follicular keratosis (IFK) is a rare benign neoplasm of the follicular infundibulum and typically presents as a solitary, nonpigmented verrucous papule on the head and neck of older males and can mimic viral warts, basal cell carcinoma (BCC), or squamous cell carcinoma (SCC). We report a case of multiple benign keratoses with IFK-like features in an 82-year-old woman undergoing ripretinib… Read on PubMed →
Topical and systemic skin aging interventions: Evidence, pitfalls and perspectives.
Biochemical pharmacology · 2026
Skin aging is a complex, multifactorial process driven by intrinsic biological factors and extrinsic environmental influences, with ultraviolet radiation playing a central role in accelerating structural and functional skin deterioration. A wide range of topical and systemic interventions have been proposed to prevent or reverse visible signs of skin aging. This review provides a critical… Read on PubMed →
Update of the EuroGuiDerm evidence-based guideline for the treatment of acne-Short version.
Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
This evidence- and consensus-based guideline for the treatment of acne was developed in accordance with the EuroGuiDerm Guideline and Consensus Statement Development Manual. This guideline is an update of the 2016 version. This is a short summary of the full version of the EuroGuiDerm Evidence-based Guideline for the Treatment of Acne. For the complete guideline text, detailed methods report, and… Read on PubMed →
Dissecting Cellulitis of the Scalp: Current Insights and Therapeutic Advances.
American journal of clinical dermatology · 2026
Dissecting cellulitis of the scalp is a rare, primary neutrophilic cicatricial alopecia that manifests with painful nodules, abscesses, and interconnected sinus tracts. It predominantly affects young adult men and frequently coexists with other follicular occlusion disorders, including hidradenitis suppurativa and acne conglobata. Clinical evaluation and trichoscopy are key elements of the… Read on PubMed →
Topical vitamins: Uses and limitations-part I.
Clinics in dermatology · 2026
Topical formulations of vitamins are increasingly used for dermatologic conditions and cosmetic indications, owing to their anti-inflammatory and antioxidant effects, modulation of cell proliferation and differentiation, wound-healing effects, and moisturizing and photoprotective properties. Apart from well-established uses in psoriasis and acne vulgaris, they are helpful for various new… Read on PubMed →
Hypervitaminosis: The deleterious effects of vitamins on the skin.
Clinics in dermatology · 2026
Vitamin supplementation has recently shown a dramatic increase in usage, especially during the COVID-19 pandemic, as a potential aid in preventing, treating, and recovering from infection. In dermatology, vitamin supplements may be used to support the management of a myriad of conditions. A common misconception is that vitamins are safe to consume and that taking more will improve overall health… Read on PubMed →
Vitamins and skin aging.
Clinics in dermatology · 2026
This comprehensive analysis sheds light on the crucial roles played by vitamins in anti-aging strategies across three key domains: topical care, cosmetic procedures, and systemic therapy. Vitamins significantly influence skin health, contributing to hydration, collagen synthesis, and protection against oxidative damage. In topical care, vitamins are harnessed in various formulations such as… Read on PubMed →
New insights into the role of CYP26 in retinoic acid clearance.
Expert opinion on drug metabolism & toxicology · 2026
INTRODUCTION: All‑trans‑retinoic acid orchestrates vertebrate development and adult tissue homeostasis. Because both deficiency and excess are deleterious, atRA concentrations must be precisely controlled, making its local clearance essential. The cytochrome P450 family members CYP26A1/B1/C1 are the principal high‑affinity retinoic acid hydroxylases that terminate signaling and sculpt RA… Read on PubMed →
Population-Specific HLA Profiles in Generalised Pustular Psoriasis in Sarawak, Malaysia.
Experimental dermatology · 2026
Genetic studies mutations (IL36RN, CARD14 and AP1S3) account for only 28.6% of generalised pustular psoriasis (GPP) leaving much of its pathogenesis remained to be elucidated. Emerging evidence suggests Th17-mediated inflammation, potentially driven by specific HLA class alleles, may underlie dysregulated IL-36 signalling. This study explores the genotypic and phenotypic features of autochthonous… Read on PubMed →
Case Report: Successful treatment of SAPHO syndrome refractory to adalimumab with upadacitinib.
Frontiers in immunology · 2026
BACKGROUND: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare autoinflammatory disorder characterized by osteoarticular and cutaneous manifestations. While tumor necrosis factor-alpha (TNF-α) inhibitors such as adalimumab are increasingly used for refractory cases, some patients exhibit inadequate response. Janus kinase (JAK) inhibitors have emerged as a potential… Read on PubMed →