Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
47 papers under Melasma & dark spots
Intense Pulsed Light Combined with Fractional CO2 Laser for Post-traumatic Hyperpigmentation: A Retrospective Study.
Aesthetic plastic surgery · 2026
INTRODUCTION: Post-traumatic hyperpigmentation (PTH) is a pigmentary condition that develops after cutaneous injury from abrasions, burns, procedures, or chemical irritation. Its course can be prolonged and cosmetically distressing, especially when involving visible areas. Although intense pulsed light (IPL) and fractional CO2 lasers are widely used for pigmentary disorders and scar treatment… Read on PubMed →
Five Steps for Effective Office-Based Neck Ultrasound-Assisted Liposuction Under Local Anesthesia: Patient Outcomes.
Aesthetic plastic surgery · 2026
BACKGROUND: The lower face, particularly the neck contour, is an essential element of facial rejuvenation. One of the most effective tools for removing accumulating fat and redraping the neck skin is liposuction, requiring appropriate patient selection for the procedure. METHODS: This retrospective study included patients who underwent office-based neck USS-assisted liposuction under local… Read on PubMed →
The relationship between clinical characteristics of melasma and sunscreen use in women: A cross-sectional, two-center study.
Clinics in dermatology · 2026
Melasma is associated with genetic factors, UV-light exposure, and hormonal influences. Because UV exposure is a crucial factor in the pathogenesis of melasma, the preventive effect of sunscreen use has been established. This cross-sectional study investigated the relationship between the clinical features of melasma and sunscreen use among 126 women attending outpatient dermatology clinics at two… Read on PubMed →
Assessing the Safety and Efficacy of Picosecond Alexandrite Lasers in the Management of Melasma: A Systematic Review and Meta-Analysis of Randomised Control Trials.
The Australasian journal of dermatology · 2026
Melasma is a chronic hyperpigmentation disorder that disproportionately affects women and individuals with darker skin types, leading to a significant psychosocial burden. This meta-analysis aims to evaluate the safety and efficacy of the 755-nm picosecond alexandrite laser (PSAL) compared with conventional therapies in the management of melasma. PubMed, Ovid Medline, Embase, Cochrane Library, and… Read on PubMed →
Interferon Alpha-2a as Treatment for Primary Acquired Melanosis With Atypia and for Primary Acquired Melanosis With Atypia Surrounding Conjunctival Melanoma.
American journal of ophthalmology · 2026
PURPOSE: To report on topical treatment with interferon (IFN) alfa-2a for conjunctival primary acquired melanosis (PAM) with atypia. DESIGN: A retrospective interventional case series. SUBJECTS: Patients diagnosed with PAM with atypia. METHODS: Patients received topical IFN α-2a, IFN α-2b, or pegylated IFN α-2a. Treatment duration, response, adverse effects, and progression-free survival (PFS)… Read on PubMed →
Incidence of Bleomycin-Induced Hyperpigmentation in Patients Undergoing Sclerotherapy for Low-Flow Vascular Malformations.
Journal of vascular and interventional radiology : JVIR · 2026
PURPOSE: To determine the incidence of bleomycin-induced hyperpigmentation in patients receiving bleomycin sclerotherapy for low-flow vascular malformations (LFVMs). MATERIALS AND METHODS: A retrospective chart review of patients with radiologically confirmed LFVM who had undergone ≥1 bleomycin sclerotherapy session. Treatments were performed at Vancouver General Hospital or British Columbia's… Read on PubMed →
Contribution of sclerotherapy to the management of chronic venous insufficiency at the Abidjan Heart Institute: A preliminary study.
Vascular diseases (Paris, France) · 2026
INTRODUCTION: Sclerotherapy is a minimally invasive technique that offers an effective alternative to surgical management of chronic venous insufficiency. Despite its growing use worldwide, its application remains underreported in Sub-Saharan Africa. This preliminary study aims to evaluate the clinical outcomes and therapeutic value of sclerotherapy in patients with superficial chronic venous… Read on PubMed →
Fibroblast-directed melanocyte recruitment via Cxcl12-Cxcr4 axis promotes post-inflammatory hyperpigmentation and skin barrier protection in zebrafish.
Journal of genetics and genomics = Yi chuan xue bao · 2026
Post-inflammatory hyperpigmentation (PIH) is a common skin disorder characterized by brown or black macules. It can be categorized as transient, typically resolving within 6-12 months, or permanent, persisting for years. While the pathogenesis of PIH is commonly linked to localized melanocyte overactivation, the precise cellular and molecular basis for this dysregulation, as well as its… Read on PubMed →
Distinct polyp recurrence timing and STK11 mutation status underlie clinical heterogeneity in pediatric Peutz-Jeghers syndrome.
Journal of pediatric gastroenterology and nutrition · 2026
OBJECTIVES: Clinically, recurrent polyp growth is a characteristic feature of pediatric Peutz-Jeghers syndrome (PJS) patients. However, the clinical characteristics of pediatric PJS patients grouped by postoperative recurrence time remain undefined. Furthermore, differences in clinical features between serine/threonine kinase 11 (STK11)-positive and -negative patients, and the influence of STK11… Read on PubMed →
Gastric outlet obstruction secondary to Peutz-Jeghers syndrome successfully managed by polypectomy.
Clinical journal of gastroenterology · 2026
Peutz-Jeghers syndrome (PJS) is a genetic disorder characterized by the development of hamartomatous polyps throughout the gastrointestinal tract but primarily in the small bowel. Gastric outlet obstruction (GOO) due to PJS polyps is rare in childhood. The optimal treatment of large, gastric polyps in PJS remains unclear. We report herein the case of a 1-year-old, male patient who was treated… Read on PubMed →
A novel ZIC1-BMP4 axis identified in photoaged dermal fibroblasts regulates melanogenesis.
Journal of dermatological science · 2026
BACKGROUND: Chronic ultraviolet exposure induces photoaging and pigmentation, contributing to disorders such as melasma. However, treatments for photoaging-related pigmentation still challenging, implying upstream regulators remain incompletely understood. OBJECTIVES: To identify the key regulators involved in photoaging-related pigmentation. METHODS: We integrated bulk RNA-seq data of… Read on PubMed →
Analysis of self-management behaviors and related factors in patients with postherpetic neuralgia: A multidimensional methodological study.
Geriatric nursing (New York, N.Y.) · 2026
OBJECTIVE: This study aimed to evaluate the current state of self-management behaviors among patients suffering from postherpetic neuralgia (PHN) and to ascertain the principal determinants of these behaviors. METHODS: From March to July 2024, 268 PHN inpatients were enlisted from the Pain Department of Guizhou Medical University Hospital through a convenience sampling method. Data were gathered… Read on PubMed →
A randomized controlled trial of 3% polidocanol foam with saline prewashing compared with standard foam sclerotherapy for the treatment of varicose veins.
Journal of vascular surgery. Venous and lymphatic disorders · 2026
BACKGROUND: Chronic venous disease is a highly prevalent global condition. Sclerotherapy with polidocanol foam is an established minimally invasive treatment. However, complications such as postprocedural hyperpigmentation remain common, and the maximum injectable volume per session may limit treatment efficacy. These factors highlight the need for optimized techniques to enhance vein occlusion… Read on PubMed →
Clinical characteristics and factors affecting quality of life in children with congenital adrenal hyperplasia.
Pakistan journal of pharmaceutical sciences · 2026
BACKGROUND: Congenital Adrenal Hyperplasia (CAH) is a group of disorders characterized by impaired adrenal steroid hormone synthesis, with a wide spectrum of clinical manifestations. The prognosis of CAH depends on factors, such as clinical phenotype, treatment and management. OBJECTIVES: To analyze the factors influencing the quality of life in children with CAH. METHODS: This retrospective… Read on PubMed →
Successful Management of a Facial Traumatic Asphalt Tattoo Using Sequential Q-Switched Nd:YAG and Fractional CO₂ Lasers.
Lasers in surgery and medicine · 2026
OBJECTIVES: To describe a stepwise, non-invasive dual-laser approach for the treatment of a traumatic facial asphalt tattoo. METHODS: A 30-year-old woman presented 18 months after a motor vehicle accident with a persistent dyschromic, atrophic plaque containing embedded asphalt particles on the right hemiface. A 12-session treatment strategy combining Q-switched Nd:YAG laser (1064 nm; 4-5 ns… Read on PubMed →
Efficacy and safety of hemostatic net in facelift and rejuvenation surgeries (browlift and necklift): A systematic review and meta-analysis.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS · 2026
BACKGROUND: Facelifts are commonly associated with postoperative complications. The hemostatic net has emerged as a promising approach to reduce these events. The aim of this meta-analysis was to evaluate the efficacy and safety of the hemostatic net in facelift. METHODS: The PubMed, Embase, and Cochrane databases were systematically searched up to May 2025 for studies evaluating the hemostatic… Read on PubMed →
Efficacy of Alexandrite picosecond laser therapy with and without dermal polyrevitalisation (NCTF® 135 HA) in patients with melasma: A Randomised Controlled Trial.
La Clinica terapeutica · 2026
OBJECTIVES: This randomised controlled trial aimed to compare the efficacy of Alexandrite picosecond laser therapy combined with dermal polyrevitalisation (NCTF® 135 HA) with laser therapy alone for reducing the severity of melasma. The outcomes were assessed using 3D imaging and the Dermatology Life Quality Index (DLQI). The secondary objectives were to evaluate the safety and tolerability of the… Read on PubMed →
Tranexamic acid protects human dermal fibroblasts from D-galactose-induced senescence via the GPR30/MAPK pathway.
Annals of medicine · 2026
BACKGROUND: Tranexamic acid (TXA) is widely used for pigmentary disorders, but its anti-ageing potential remains unclear. This study aimed to evaluate whether topical 3% TXA improves early periorbital wrinkles in women with facial melasma and to investigate whether TXA protects human dermal fibroblasts from D-galactose-induced senescence via the GPR30/MAPK pathway. METHODS: Fifty women with… Read on PubMed →
Bone Marrow Mesenchymal Stem Cell Extracellular Vesicle Treatment of Respiratory Failure from COVID-19: Endpoint Analysis of Expanded Access Safety Trial.
Stem cell reviews and reports · 2026
The safety of an extracellular vesicle (EV) enriched secretome from bone marrow mesenchymal stem cells (BM-MSCs) was evaluated in a multi-site, prospective, expanded access trial as potential treatment for respiratory failure due to COVID-19. Subjects (103) received up to three doses of 15 mL IP every 72 h. The primary outcome was all cause 60-day mortality. Secondary outcomes included serious… Read on PubMed →
Safety and Tolerability of Fractional CO2 Lasers for Facial Rejuvenation Across Fitzpatrick Skin Phototypes I-IV: Retrospective Cohort Study.
Journal of cosmetic dermatology · 2026
BACKGROUND: Fractional CO2 laser is an effective treatment for skin rejuvenation, although pigmentary complications remain a clinical consideration. Newer generation fractional CO2 laser systems include pulse modes such as HighPulse (HP), which deliver high energy over a shortened dwell time, reducing the duration of energy delivery per microbeam with the aim of limiting thermal diffusion beyond… Read on PubMed →