Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
32 papers under Hair loss
Efficacy of polyphenolic compounds for hair regeneration: a systematic review and meta-analysis of randomized controlled trials.
The Journal of dermatological treatment · 2026
BACKGROUND: Non-scarring alopecia, including androgenetic alopecia, alopecia areata, and telogen effluvium, is highly prevalent and often associated with significant psychosocial burden. Although treatments such as minoxidil and finasteride are available, variability in response and tolerability concerns have increased interest in alternative therapeutic approaches. Polyphenolic compounds have… Read on PubMed →
Exploring the efficacy evaluation model for androgenic alopecia using hair organoids: Transcending conventional hair research.
Journal of dermatological science · 2026
BACKGROUND: The development of effective evaluation tools for anti-hair loss therapies is critical due to limitations in existing experimental systems. Hairy 3D skin models and hairy skin explants are not yet commercially viable, necessitating alternative approaches for assessing androgenic alopecia (AGA). OBJECTIVE: This study aimed to develop a hair-bearing organoid model derived from embryonic… Read on PubMed →
Enhanced follicular delivery of minoxidil to human scalp skin using cetosomal formulation.
Colloids and surfaces. B, Biointerfaces · 2026
BACKGROUND: Androgenetic alopecia (AGA) is a common condition marked by progressive hair follicle miniaturization, for which topical minoxidil remains a first-line therapy. However, conventional hydroalcoholic formulations are associated with poor scalp retention, rapid drug loss, and local irritation. This study evaluated the follicular targeting, skin retention, and mechanistic behavior of a… Read on PubMed →
Efficacy and Safety of Fractional Laser Therapy for Androgenetic Alopecia: A Systematic Review and Meta-Analysis.
Journal of cosmetic dermatology · 2026
OBJECTIVE: To systematically evaluate the efficacy and safety of fractional laser therapy in the treatment of androgenetic alopecia. METHODS: A comprehensive literature search was conducted in PubMed, Web of Science, Embase, the Cochrane Library, and China National Knowledge Infrastructure (CNKI) from inception to November 2025. Eligible studies were selected according to the PICOS framework. The… Read on PubMed →
Case Report: Dupilumab induced sustained complete remission in a child with severe alopecia areata and markedly elevated IgE.
Frontiers in immunology · 2026
BACKGROUND: Severe alopecia areata in children is difficult to treat, and conventional therapies often show limited efficacy and substantial adverse effects. Dupilumab has shown potential in patients with alopecia areata and an atopic background, and baseline IgE has been proposed as a predictor of response. However, long-term outcomes and maintenance strategies in children with very high IgE… Read on PubMed →
Therapeutic update on alopecia areata: a critical review of standard and emerging targeted therapies.
Inflammopharmacology · 2026
BACKGROUND AND OBJECTIVES: This narrative review provides a comprehensive update on the pathogenesis and therapeutic management of alopecia areata (AA), critically evaluating the transition from non-specific immunosuppression to targeted molecular therapies. METHODS: A literature search was conducted across PubMed, Scopus, and the Cochrane Library (inception to 2024). A strict hierarchy of… Read on PubMed →
Venlafaxine reverses chemotherapy-induced alopecia through epithelial and dermal reprogramming at single-cell resolution.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026
Chemotherapy-induced alopecia (CIA) is a frequent and distressing adverse effect of cytotoxic cancer therapy that significantly affects patients' quality of life, yet its cellular mechanisms remain incompletely understood and effective pharmacological interventions are limited. Here, we combined single-cell RNA sequencing with in vivo mouse models and ex vivo human hair follicle organ culture to… Read on PubMed →
Discovery and evaluation of SIPI11594: a novel mitochondrial pyruvate carrier inhibitor with anti-hair loss efficacy.
Bioorganic & medicinal chemistry · 2026
Inhibition of the mitochondrial pyruvate carrier (MPC) is a promising strategy to promote hair follicle stem cell activation via lactate production for treating alopecia. To identify new MPC inhibitors, we designed and synthesized 32 novel α-cyano-4-hydroxycinnamate derivatives based on a N1-arylmethylpyridine compound 4I. Structure-activity relationship analysis identified C4-substitution on the… Read on PubMed →
Case Report: Bimekizumab for dissecting cellulitis of the scalp.
Frontiers in immunology · 2026
Dissecting cellulitis of the scalp (DCS) is a cicatricial alopecia characterized by follicular occlusion that progresses to abscess formation and rupture, driven by an intense inflammatory cascade. Part of the follicular occlusion tetrad, DCS typically presents with painful nodules and interconnecting sinus tracts localized to the scalp. Treatment of this recalcitrant disease is difficult, and… Read on PubMed →
Exosomes in Hair Restoration.
Dermatologic clinics · 2026
Androgenetic alopecia is the most common cause of progressive hair loss and has substantial impact on quality of life. Conventional treatments, including minoxidil and finasteride, are limited by variable response rates and side effects. Exosomes, which are nanosized extracellular vesicles involved in cell-cell communications, have emerged as promising candidates in hair restoration. Preclinical… Read on PubMed →
Novel 2-Phenyl-1H-Pyrrole Derivatives as Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss.
Chemical biology & drug design · 2026
Hair follicle stem cells (HFSCs) play the primary role in the regulation of the hair growth cycle. Premature termination of the anagen phase accelerates the transition of hair follicles into the catagen and telogen phases, leading to hair loss. Inhibiting the mitochondrial pyruvate carrier (MPC), which prevents pyruvate from entering mitochondria, enhances lactate synthesis. This activates HFSCs… Read on PubMed →
Case Report: Paradoxical psoriasis under TNF-α blockade may represent generalized abscessing staphyloderma - GASD syndrome by TNF antagonists.
Frontiers in immunology · 2026
Patients treated with TNF-α antagonists may develop psoriasis-like skin lesions. Clinical manifestations include palmoplantar, inverse, localized or generalized guttate, plaque-type, eczematous, and pustular lesions; deep inflammatory nodes; and nonscarring alopecia, often with overlapping reaction patterns. They are classified as paradoxical psoriasis and interpreted as an inflammatory reaction… Read on PubMed →