Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
Showing research linked to Cutibacterium Acnes (view profile)
Clear18 papers
Lacticaseibacillus parahuelsenbergensis THGS-36 alleviates acne-like inflammation and lipogenesis in sebocytes via CREB signaling.
Life sciences · 2026
Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit and is associated with Cutibacterium acnes overgrowth, excessive sebum production, and persistent inflammatory responses. This study evaluated the anti-acne potential of the cell-free supernatant (CFS) from Lacticaseibacillus parahuelsenbergensis THGS-36 and investigated its host-modulatory effects in sebocytes with a focus… Read on PubMed →
Traditional Chinese medicine in acne treatment: From classical formulas to bioactive phytoconstituents and mechanisms.
Journal of ethnopharmacology · 2026
ETHNOPHARMACOLOGICAL RELEVANCE: Acne vulgaris is a multifactorial inflammatory skin condition that affects over 80% of adolescents worldwide. Conventional monotherapy often fails to address sebaceous hyperplasia, Cutibacterium acnes dysbiosis and epidermal barrier dysfunction concurrently. Traditional Chinese herbal medicine (CHM) has long been used to treat acne patterns such as 'damp-heat' or… Read on PubMed →
Hormonal acne therapies in pediatrics.
Current opinion in pediatrics · 2026
BACKGROUND: Acne vulgaris is one of the most common inflammatory skin conditions in adolescents, affecting up to 85% of individuals aged 12-24 years. Beyond its physical manifestations, acne can significantly impact self-esteem, quality of life, and psychological well-being. DISCUSSION: Acne has a multifactorial pathogenesis involving follicular hyperkeratinization, increased sebum production… Read on PubMed →
CBD-Containing Hemp Extracts and Isolated CBD for Acne: A Systematic Review of Anti-Inflammatory Mechanisms, Clinical Signals and Sustainability.
Molecules (Basel, Switzerland) · 2026
Industrial hemp (Cannabis sativa L.) has emerged as a sustainable source of bioactive compounds, with increasing interest in cosmeceutical applications for acne management. This systematic review synthesises evidence on cannabinoid-containing hemp extracts, particularly cannabidiol (CBD), with emphasis on anti-inflammatory and sebostatic mechanisms, alongside formulation considerations and… Read on PubMed →
Oral probiotics and topical secretome to enhance clinical outcomes and microbiome restoration in acne vulgaris: a double-blind, randomised controlled trial protocol.
BMJ open · 2026
BACKGROUND: Acne vulgaris is a chronic inflammatory condition primarily caused by Cutibacterium acnes, which disrupts skin homeostasis, thereby triggering immune responses and sebum metabolism. Dysbiosis is an imbalance in the skin and gut microbiota identified as a significant factor contributing to acne progression. Standard therapy often relies on antibiotics, but the long-term use has… Read on PubMed →
Randomized Controlled Study of Bacteriophages in Acne Reveals Efficacy and Novel Mechanism for Promoting Long-Term Skin Health.
Journal of drugs in dermatology : JDD · 2026
BACKGROUND: Acne is the most prevalent skin disease globally, with a significant burden and limited therapeutic innovation. Although it has a multifactorial etiology, Cutibacterium acnes (C acnes) overgrowth is a key factor in driving inflammation in acne. Bacteriophages are a novel mechanism that can specifically target C acnes and are found in greater abundance on healthy skin compared to… Read on PubMed →
A Novel Retinoid and Salicylic Acid Topical Treatment for Moderate-Severe Acne.
Journal of drugs in dermatology : JDD · 2026
BACKGROUND: Advances in biotechnology have enabled highly effective, site-specific topical therapies for skin disease. Particle-based delivery systems can be engineered with tailored physicochemical properties and surface modifications to optimize controlled drug release and skin targeting, potentially improving acne treatment outcomes. OBJECTIVE: To evaluate the effectiveness and tolerability of… Read on PubMed →
A co-amorphous salt of ursodeoxycholic acid and matrine incorporated into dissolving microneedles for combined antibacterial and anti-inflammatory treatment of acne vulgaris.
International journal of pharmaceutics · 2026
Acne vulgaris is characterized by microbial dysbiosis and excessive inflammatory activation, whereas current topical therapies are often limited by poor skin penetration and increasing antibiotic resistance. Ursodeoxycholic acid (UDCA) has anti-inflammatory potential but suffers from low aqueous solubility and limited cutaneous permeability. In this study, a co-amorphous salt of UDCA and matrine… Read on PubMed →
Piceatannol from Passion Fruit Seed Waste: A Circular Bioeconomy-Driven Pathway Toward a Skin-Targeted Bioactive.
International journal of molecular sciences · 2026
Passiflora edulis (passion fruit) seed waste, an abundant by-product of the juice industry, is a promising source of piceatannol (PIC), a hydroxystilbene with superior antioxidant activity compared to resveratrol. However, its translation into a skin-targeted ingredient remains hindered by a lack of standardization and clinical validation. This review synthesizes current evidence on the… Read on PubMed →
Chemical Characteristics and Antimicrobial Activity of Arctostaphylos uva-ursi (L.) Spreng. Extracts Against Skin-Associated Bacteria.
Molecules (Basel, Switzerland) · 2026
The interest in the use of phytochemicals and herbal medicines for the treatment of acne vulgaris has grown steadily over recent decades. The research on the secondary metabolites and biological properties of bearberry (Arctostaphylos uva-ursi (L.) Spreng.) has been intensified in recent years, but the range of bacterial strains tested, many of which are highly relevant to human health, remains… Read on PubMed →
Evaluation of the Antimicrobial Potential of Malaysian Kelulut Honeydew Honey Against Acne Pathogens.
Current microbiology · 2026
Acne is the eighth most prevalent chronic skin disease globally. The increased emergence of antibiotic resistance and chemical-induced side effects make acne treatments challenging. Hence, a natural remedy, Malaysian Kelulut honeydew honey, was proposed in this research due to its beneficial properties and the absence of antibiotic resistance. An in vitro efficacy of honey was evaluated against… Read on PubMed →
The Effect of Myrtacine and Celastrol-Enriched Extract on Cutibacterium acnes Extracellular Vesicles.
International journal of dermatology · 2026
BACKGROUND: Commensal bacteria interact with each other and their environment, secreting anti-microbial peptides, bacteriocins, and extracellular vesicles (EVs). Cutibacterium acnes (C. acnes), a commensal bacterium that plays a major role in acne, is classified into different phylotypes (IA1, IA2, IB, IC, II, and III), where overabundance of phylotype IA1 relative to other phylotypes is found in… Read on PubMed →
Proteoglycan Mimetics-Based Antimicrobial and Anti-Inflammatory Microneedles Restoring Dysregulated Lipid Metabolism and Suppressing Skin Atrophy for Acne Treatment.
Small (Weinheim an der Bergstrasse, Germany) · 2026
Over 15% of acne patients manifest moderate to severe clinical presentations, accompanied with bacterial infection, long-term inflammatory responses, dysregulated lipid metabolism, and post-acne skin atrophy. Although microneedles (MNs) represent an effective transdermal drug delivery system for acne treatment, the therapeutic effects on the restoration of dysregulated lipid metabolism and the… Read on PubMed →
Unlocking the antibacterial potential of Zanthoxylum armatum fruit: A bioactive approach to treat acne vulgaris.
Microbial pathogenesis · 2026
Dermatology has a huge challenge when treating skin infections caused by germs such Cutibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis. Natural bioactive substances originating from plant sources may be employed as therapeutic agents to treat certain disorders is gaining popularity. In this study, we evaluated the potential of bioactive chemicals of Zanthoxylum armatum… Read on PubMed →
Antimicrobial resistance in commensal skin bacteria among individuals without prior exposure to acne therapy.
Journal of global antimicrobial resistance · 2026
OBJECTIVE: Antimicrobial resistance (AMR) in skin bacteria is a salient issue in patients with acne vulgaris. This study aimed to investigate the AMR status of skin bacteria isolated from university student volunteers with no history of treating acne. METHODS: We evaluated the antimicrobial susceptibility of Staphylococcus epidermidis and Cutibacterium acnes, isolated in 2014 and 2019 from… Read on PubMed →
Chemical identification of the Viola phillipina extracts and their anti-acne activity: A comparison with isotretinoin and salicylic acid.
Fitoterapia · 2026
Since acne is a multifactorial condition, its treatment remains challenging. The multi-target efficacy of plant extracts may be a better way to treat it. In this paper, the components of Viola philippica extracts with different polarity were analyzed by HPLC, and the anti-acne activities were studied from sebum inhibition, anti-inflammatory and bacteriostasis. Results revealed that… Read on PubMed →
Development and evaluation of a multifunctional natural composite microemulsion for anti-acne therapy: synergistic anti-inflammatory and antibacterial effects.
Drug development and industrial pharmacy · 2026
INTRODUCTION: Acne is a common inflammatory disease of the hair follicles and sebaceous glands, but most of the current treatments have side effects or drug resistance problems. This study developed a stable, self-emulsifying composite Microemulsion (PHS-ME) co-loaded with paeonol, honokiol and Salix alba (white willow) bark extract. METHODS: The formulation was optimized using Box-Behnken… Read on PubMed →
Anti-quorum-sensing activity of Plectranthus aliciae in multispecies Cutibacterium acnes-Staphylococcus epidermidis systems.
Phytomedicine : international journal of phytotherapy and phytopharmacology · 2026
BACKGROUND: Quorum sensing (QS) is a bacterial communication process mediated by the production, release, and detection of autoinducers, regulating gene expression linked to virulence and biofilm formation. Cutibacterium acnes and Staphylococcus epidermidis exhibit opportunistic pathogenic behavior on the skin, complicating treatment strategies for inflammatory skin conditions such as acne… Read on PubMed →