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Injectable VEGF-loaded gelatin-hyaluronic acid hydrogel to synergistically promote flap survival via rapid angiogenesis.

Journal of materials chemistry. B · 2026

Random-pattern skin flaps are commonly used in plastic surgery to close skin defects, but necrosis often occurs in the distal portions of flaps due to insufficient blood supply, which severely limits their clinical utility. Thus, we developed a vascular endothelial growth factor (VEGF)-loaded injectable hydrogel to promote local angiogenesis to improve skin flap survival. The hydrogel, composed of… Read on PubMed →