Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
Showing research linked to Retinoic Acid (view profile)
Clear9 papers
DGAT1 regulates keratinocyte proliferation through the modulation of retinoid homeostasis.
Journal of physiology and biochemistry · 2026
Multiple mechanisms contribute to skin barrier integrity, and emerging evidence suggests that acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) plays a key role in its regulation through both lipid and retinoid metabolism. Although DGAT1 deficiency leads to cutaneous abnormalities, the direct role of DGAT1 in keratinocyte biology remains unclear. Here, we show that DGAT1 deficiency drives… Read on PubMed →
Konjac Ceramide Induces Semaphorin 3A Expression via the MAPK/AP-1 Signaling Axis and RORα in Normal Human Epidermal Keratinocytes.
Biomolecules · 2026
Epidermal hyperinnervation is a major cause of intractable itch in barrier dysfunction conditions such as atopic dermatitis. Keratinocyte-derived semaphorin 3A (Sema3A) suppresses epidermal hyperinnervation, but its expression is markedly reduced in barrier-disrupted skin. Although konjac ceramide (kCer) has been reported to act as a Sema3A-like ligand, the mechanisms by which it regulates Sema3A… Read on PubMed →
Silk Sericin Functionalized with Carboxy Drugs for Dermocosmetic Applications.
ACS applied bio materials · 2026
Silk sericin protein, a textile industry by-product showing no toxicity on oral/topical administration, has recently been exploited as a drug delivery system. The high serine content in sericin makes its functionalization through covalent ester-type bonds feasible; however, only in a few cases have covalent conjugates of sericin with the drug to be delivered been developed. In this paper, we… Read on PubMed →
Vitamin A: Biological Functions and Implications for Muscle Health.
Nutrition reviews · 2026
Skeletal muscle diseases represent a diverse group of conditions, often characterized by muscle weakness, atrophy, and functional impairment. These disorders continue to impose a significant burden on global health, affecting millions of individuals worldwide. As the prevalence of muscle-related diseases rises, it becomes increasingly important to understand the complex biological mechanisms that… Read on PubMed →
Inhibiting LSD1 unlocks retinoid AP-1 programming to activate epithelial immunity and skin tumor suppression.
The Journal of clinical investigation · 2026
Lysine-specific demethylase 1 (LSD1; KDM1A) orchestrates context-dependent chromatin programs, yet its role in epithelial immunity remains largely unknown. Here, we identify LSD1 as a central brake on retinoid-driven and activator protein-1-driven (AP-1-driven) enhancer activation in epidermis and demonstrate that its inhibition induces antitumor immunity. Whereas epidermal LSD1 is required during… Read on PubMed →
Retinoic acid at the crossroads of reproduction and sleep: an underexplored link with clinical implications.
Reproduction (Cambridge, England) · 2026
Retinoic acid, a vitamin A derivative widely used in dermatology, plays essential roles in female and male reproductive physiology and in the regulation of circadian rhythms. Emerging evidence suggests that chronic exposure to systemic retinoids, such as isotretinoin, may influence fertility parameters and sleep-reproductive interactions, highlighting the need for greater clinical awareness and… Read on PubMed →
Retinoic Acid Signaling Alters the Balance of Epidermal Stem Cell Populations in the Skin.
The Journal of investigative dermatology · 2026
All-trans retinoic acid, the active form of retinoid, is a potent antiaging and anti-inflammatory agent with pleiotropic effects on various skin conditions. In the interfollicular epidermis, tissue turnover is maintained by heterogeneous epidermal stem cell populations located at the basal layer. Mouse tail skin contains slow- and fast-cycling epidermal stem cell populations. The reduction of… Read on PubMed →
Antioxidant regulatory mechanisms of retinoic acid and its therapeutic potential in oxidative stress-related diseases.
Biochemical pharmacology · 2026
As a metabolite of vitamin A, retinoic acid (RA) is bound to nuclear receptors (RAR/RXR) to produce effects and regulate gene expression, showing antioxidant, anti-inflammatory, and anti-apoptotic activities [1]. Oxidative stress, induced by both endogenous and exogenous factors, results in the excessive accumulation of reactive oxygen species (ROS) in specific areas, which can damage cellular… Read on PubMed →
New insights into the role of CYP26 in retinoic acid clearance.
Expert opinion on drug metabolism & toxicology · 2026
INTRODUCTION: All‑trans‑retinoic acid orchestrates vertebrate development and adult tissue homeostasis. Because both deficiency and excess are deleterious, atRA concentrations must be precisely controlled, making its local clearance essential. The cytochrome P450 family members CYP26A1/B1/C1 are the principal high‑affinity retinoic acid hydroxylases that terminate signaling and sculpt RA… Read on PubMed →