Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
Showing research linked to Hyaluronic Acid (view profile)
Clear58 papers
Hyaluronic Acid Dermal Filler-Associated Vascular Occlusion-A Review of Prevention and Management Strategies.
Journal of cosmetic dermatology · 2026
BACKGROUND: Significant complications are uncommon with aesthetic hyaluronic acid (HA) dermal fillers, but inadvertent injection of dermal filler into an artery can result in tissue damage, scarring, visual loss, and even stroke. Practitioners must therefore reduce this risk through proactive, preventative techniques. Early recognition of vascular occlusion (VO) is also crucial to minimize… Read on PubMed →
Recent Advances in Novel Drug Delivery Systems for the Management of Cutaneous Squamous Cell Carcinoma.
International journal of nanomedicine · 2026
Cutaneous squamous cell carcinoma (cSCC) is a type of cancer that originates from the growth of skin cells. It represents the second most common form of non-melanoma skin cancer and primarily arises from the malignant proliferation of keratinocytes in the epidermis or skin appendages. The global incidence of cSCC is increasing, and its onset is primarily associated with prolonged exposure to… Read on PubMed →
Hyaluronidase Reverses the Effect of Hyaluronic Acid Without Destroying Normal Skin Structure.
Journal of cosmetic dermatology · 2026
BACKGROUND: Dermal fillings based on hyaluronic acid have been widely used in facial rejuvenation. A number of studies have reported the beneficial effect of hyaluronidase in saving the complications of hyaluronic acid. However, the effects of hyaluronidase on dermal matrix, skin structure, and fibroblast function are unknown. METHOD: In this study, hyaluronic acid and hyaluronidase were injected… Read on PubMed →
Cross-Linked Sodium Hyaluronate Filler Containing Poly-L-Lactic Acid-b-Poly (Ethylene Glycol) Microspheres for Periorbital Rejuvenation: A Multimodal Assessment of Physicochemical, Preclinical, and Clinical Performance.
Journal of cosmetic dermatology · 2026
BACKGROUND: Periorbital rejuvenation presents significant challenges: hyaluronic acid (HA) fillers carry risks of edema and the Tyndall effect, whereas traditional poly-L-lactic acid (PLLA) may lead to nodule formation and delayed inflammatory reactions. To address these limitations, the PLLA-b-poly (ethylene glycol) (PLLA-b-PEG)/HA composite filler is designed to optimize tissue compatibility and… Read on PubMed →
The hyaluronan receptor CD44 drives COVID-19 severity through its regulation of neutrophil migration.
PLoS pathogens · 2026
The novel respiratory disease COVID-19 caused by the coronavirus SARS-CoV-2 continues to be a public health emergency worldwide, and there is a need for more effective therapy for patients. The relationship between the extracellular matrix and the host immune response to infection is severely understudied. Deposition of the polysaccharide hyaluronan (HA) into the lungs is associated with more… Read on PubMed →
Multifunctional hydrogels loaded with tannic acid-modified MXene for synergistic photothermal/pharmacological treatment of infected wounds caused by drug-resistant bacteria.
Biomaterials advances · 2026
The development of advanced dressings capable of integrating multiple therapeutic modalities represents a promising strategy for promoting the healing of complex infected wounds. Herein, we developed a multifunctional hydrogel dressing (OC-MT-AG) based on tannic acid-modified MXene (MT) and ampicillin/ glutamine (AG) for the synergistic treatment of drug-resistant bacterial-infected wounds. The… Read on PubMed →
Bioactive levan polysaccharides in cosmeceutical applications: A review.
International journal of biological macromolecules · 2026
Levan, a β-(2,6)-linked fructose homopolysaccharide, has gained increasing attention as a multifunctional biopolymer for cosmetic and cosmeceutical applications. Owing to its distinctive molecular architecture, levan uniquely combines high molecular weight, pronounced bioadhesive capacity, and remarkably low intrinsic viscosity, which facilitates its integration into diverse formulation platforms… Read on PubMed →
A multifunctional adhesive antibacterial chitosan/hyaluronic acid hydrogel enabling sustained release of human umbilical cord mesenchymal stem cell-derived exosomes for accelerated full-thickness skin repair.
International journal of biological macromolecules · 2026
Promoting skin wound healing is a major global public health challenge. Stem cell exosomes are regarded as a promising and ideal therapeutic approach. However, effective stem cell exosome therapy also depends on suitable vectors to promote the release and stability of exosomes. In this study, exosomes derived from human umbilical cord mesenchymal stem cells (UCMSCs-exo) were loaded into… Read on PubMed →
A review of biomacromolecular hydrogels inspired by regenerative organisms: Translating biological insights into tissue integration and regeneration.
International journal of biological macromolecules · 2026
Regenerative biology offers powerful insights into scarless healing and functional tissue integration, yet translating these biological principles into clinically effective biomaterials remains a major challenge. Biological macromolecule-based hydrogels, derived from natural proteins and polysaccharides, have emerged as promising platforms to bridge this gap due to their intrinsic bioactivity… Read on PubMed →
Safe and effective restoration of jawline definition with hyaluronic acid injectable gel: a systematic review and meta-analysis.
Acta dermatovenerologica Alpina, Pannonica, et Adriatica · 2026
A well-defined jawline is an important aspect of facial aesthetics, contributing to overall appearance. This feature is particularly sought after by individuals, especially older adults, who are interested in enhancing their facial contours. This systematic review and meta-analysis evaluates safety and effectiveness following use of VYC-25L, a hyaluronic acid-based injectable gel, for restoration… Read on PubMed →
Quantitative Assessment of Polydioxanone Microsphere Fillers for Nasolabial Fold Correction: A Comparative Study.
In vivo (Athens, Greece) · 2026
BACKGROUND/AIM: Dermal fillers are essential tools for facial rejuvenation. This study evaluated the clinical efficacy and safety of a polydioxanone (PDO)-based filler from UltraV, compared with established commercial alternatives for improving nasolabial fold wrinkles. MATERIALS AND METHODS: Thirty-one participants (aged 20-59 years) were enrolled in this prospective, split-face comparative… Read on PubMed →
Bioactive-Loaded Detachable Crosslinked Hyaluronic Acid Microneedles: Structural Validation and Clinical Anti-Wrinkle Efficacy.
Journal of biomedical materials research. Part A · 2026
Delivering a persistent biopolymer matrix to the superficial dermis remains a significant challenge for microneedle systems due to the inherent limitations of conventional dissolving platforms. Here, we present a detachable microneedle design that permits rapid needle separation during administration. To biologically compensate for the relatively short 350 μm needle geometry designed for at-home… Read on PubMed →
Efficacy and Safety of Non-Cross-Linked Hyaluronic Acid Mesotherapy for Post-Acne Erythema: A Split-Face, Prospective, Randomized, Single-Center Trial.
Journal of cosmetic dermatology · 2026
BACKGROUND: Post-acne erythema (PAE) is one of the most common inflammatory sequelae of acne. Although various therapeutic approaches are currently available, many are limited by suboptimal efficacy, poor tolerability, or high costs. This trial aims to evaluate the clinical efficacy and safety of non-cross-linked hyaluronic acid (HA) mesotherapy for the treatment of PAE. METHODS: A total of 25… Read on PubMed →
Multifunctional Hyaluronic Acid Releasing Hydrogel Film With Nano/Micro Wrinkles: Thin Acne Patch for Localized Therapeutics.
Macromolecular bioscience · 2026
Hyaluronic acid (HA) is effective in reducing skin inflammation and sebum production in acne vulgaris. Localized treatment with HA involves rapid dissolving microneedle-based formulations to penetrate and release active ingredients. These causes discomfort and secondary wounds, which eventually aggravate inflammatory responses, thereby increasing the risk of scaring and pathogenesis. This study… Read on PubMed →
Multitargeted Modulation of Skin Dullness by HNHT Formulation: Synergistic Inhibition of Melanogenesis, Glycation, and Lipofuscin Deposition.
Journal of cosmetic dermatology · 2026
BACKGROUND: Skin dullness, characterized by pigmentation disorders and yellowing, is a major cosmetic concern in Asian populations. Lipofuscin exhibits ultraviolet (UV)/visible light spectral absorption, reduces skin reflectance, and contributes to dullness, whereas existing therapies targeting melanogenesis and glycation lack comprehensive efficacy. This study aimed to evaluate the multimodal… Read on PubMed →
Topical and systemic skin aging interventions: Evidence, pitfalls and perspectives.
Biochemical pharmacology · 2026
Skin aging is a complex, multifactorial process driven by intrinsic biological factors and extrinsic environmental influences, with ultraviolet radiation playing a central role in accelerating structural and functional skin deterioration. A wide range of topical and systemic interventions have been proposed to prevent or reverse visible signs of skin aging. This review provides a critical… Read on PubMed →
International Expert Consensus on Integrated Skincare Active Ingredients for Pretreatment and Posttreatment Use With Medical Aesthetic Procedures to Enhance Skin Benefits.
Journal of cosmetic dermatology · 2026
BACKGROUND: Integrated skincare (ISC) combines dermocosmetics with medical aesthetic procedures to improve outcomes. However, guidance on selecting appropriate active ingredients across different procedure types and phases remains limited. AIMS: To provide international guidance on appropriate ISC actives for use with aesthetic procedures. METHODS: In a simplified Delphi study, 14 experts… Read on PubMed →
Design and evaluation of multi-target AGEs/ALEs inhibitors for potential application in skin anti-aging.
Future medicinal chemistry · 2026
The main causes of skin aging include both intrinsic and extrinsic factors such as oxidative stress triggered by reactive oxygen species (ROS), modification of collagen and elastin by reactive carbonyl species (RCS), UV exposure, lifestyle habits and environmental pollutants. Skin aging is the most visible manifestation of senescence and is unavoidable. In particular, delaying age-related changes… Read on PubMed →