Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
Showing research linked to Hyaluronic Acid (view profile)
Clear58 papers
Targeted discovery of anti-skin aging peptides from Camelus bactrianus placenta: Multi-activity screening, network pharmacology, and in vitro validation focusing on MMP-1 inhibition.
Journal of ethnopharmacology · 2026
ETHNOPHARMACOLOGICAL RELEVANCE: Placenta has historically been utilized as a therapeutic agent in traditional medicine, notably as "Ziheche" in traditional Chinese medicine. Similarly, Camelus bactrianus placenta (CBP), known as "Haliyasu" in Mongolian medicine, has been traditionally used to promote health, reduce wrinkles, and alleviate signs of aging. However, its anti-skin aging efficacy and… Read on PubMed →
Exploring the photoprotective and antiaging potential of Padina pavonica loaded Hyatocosomes: In-vitro evaluation and biological studies.
Bioorganic chemistry · 2026
The increasing demand for effective natural ingredients has transformed the skincare market, driving interest in physiologically active compounds with proven biological effects. Padina pavonica (PA), a brown alga, is recognized for its antioxidant, anti-aging, and UV-protective properties. This study aimed to enhance the pharmacological benefits of PA via nanoencapsulation in hyatocosomes (HT), a… Read on PubMed →
Hyaluronic acid-based microneedles: materials design, fabrication strategies, challenges, and solutions for biomedical applications.
International journal of pharmaceutics · 2026
Hyaluronic acid (HA)-based microneedles have emerged as highly promising minimally invasive platforms for transdermal and transmucosal drug delivery, overcoming the limitations of conventional oral, topical, and injectable therapies. Owing to its excellent biocompatibility, biodegradability, hydrophilicity, non-immunogenicity, and intrinsic bioactivity, HA functions not only as a structural… Read on PubMed →
Matrix-tuned hyaluronic nanofibrils promoting regenerative ocular surfacing with minimal scarring.
Biofabrication · 2026
Corneal epithelial damage remains a considerable clinical challenge, often leading to delayed wound healing and impaired vision. Hyaluronic acid (HA)-based nanofibers face fabrication and stability challenges, reducing their translational potential for corneal regeneration. The fabrication and characterization of aminolyzed polycaprolactone (PCL) nanofibrils (aNFs) with manipulated HA conjugation… Read on PubMed →
Wearable near-infrared LED photothermal microneedle patch reduces periorbital wrinkles in a randomized pilot clinical trial.
Journal of materials chemistry. B · 2026
Microneedle patches are typically passive, limiting control over dissolution kinetics and transdermal transport. Here we introduce a wearable, actively actuated microneedle system in which dissolving hyaluronic-acid tips penetrate the stratum corneum while a hydrocolloid backing embedded with hyaluronic-acid-gold-nanorod (HA-GNR) nanocomposites provides near-infrared (NIR, ≈780 nm) photothermal… Read on PubMed →
Enhanced biodistribution and efficacy of nicomenthyl encapsulated in emulsions stabilized by methacrylated hyaluronic acid for the prevention and treatment of skin photoaging.
Carbohydrate polymers · 2026
Nicomenthyl (NM), prodrug of niacinamide (vitamin B3), is widely used in skin applications for their biological benefits, but remain mainly in the stratum corneum (SC). Bioactive methacrylate-functionalized hyaluronic acid (HA-MA) (44.5 KDa; degree of substitution: 80-100%), used to stabilize Oil-in-Water emulsions (EM) as new application for polysaccharide, represent an effective strategy to… Read on PubMed →
Mechanistic study on hyaluronic acid polysiloxane gel promoting wound repair guided by wet healing theory.
Biomedical materials (Bristol, England) · 2026
As a vital barrier organ of the human body, skin wound repair faces clinical challenges such as slow healing, scar hyperplasia, and infection. Although the wet healing theory has confirmed that a moist environment can enhance epidermal cell migration and reduce infection rates, the action mechanism of composite functional dressings still lacks systematic analysis. This study focuses on hyaluronic… Read on PubMed →
Injectable VEGF-loaded gelatin-hyaluronic acid hydrogel to synergistically promote flap survival via rapid angiogenesis.
Journal of materials chemistry. B · 2026
Random-pattern skin flaps are commonly used in plastic surgery to close skin defects, but necrosis often occurs in the distal portions of flaps due to insufficient blood supply, which severely limits their clinical utility. Thus, we developed a vascular endothelial growth factor (VEGF)-loaded injectable hydrogel to promote local angiogenesis to improve skin flap survival. The hydrogel, composed of… Read on PubMed →
Innovative Facial Contouring Using a Monopolar Radiofrequency Device with Continuous Water Cooling: An Integrated Clinical and Preclinical Study.
International journal of molecular sciences · 2026
Monopolar radiofrequency (MRF) is a well-established modality for non-invasive facial rejuvenation; however, its clinical utility is frequently constrained by patient discomfort and inconsistent thermal delivery. This study evaluated the efficacy, safety, and mechanistic profile of a novel MRF system incorporating continuous water cooling (RF-CWC) designed to optimize thermal distribution and… Read on PubMed →
Oleoyl-hyaluronate nanoparticles for enhanced stability and bioactivity of encapsulated coenzyme Q10.
International journal of pharmaceutics · 2026
This study presents the successful encapsulation of coenzyme Q10 (CoQ10) within sodium oleoyl hyaluronate (O-HA; Mw ∼12,000 Da) nanoparticles, creating a concentrated, liquid colloidal dispersion. The nanoprecipitation process achieved high encapsulation efficiency (up to 96%) and a loading capacity of 2.4-3.0 mg·mL-1. The physicochemical properties of these solid polymeric nanoparticles… Read on PubMed →
pH-responsive smart hydrogel dressing for controlled antimicrobial therapy and accelerated wound healing.
Journal of materials chemistry. B · 2026
Bacterial wound infections pose a major clinical challenge, often causing delayed healing, recurrent infections, and increased antibiotic resistance. Conventional antibiotics are largely ineffective against biofilm-associated bacteria, underscoring the need for advanced antimicrobial approaches. Silver nanoparticles (AgNPs) exhibit potent, broad-spectrum antibacterial activity, but their clinical… Read on PubMed →
Comparative effects of hyaluronic acid-amino acid and polynucleotide mixtures on extracellular matrix gene expression in human dermal fibroblasts.
Journal of wound care · 2026
OBJECTIVE: The extracellular matrix (ECM) provides structural and functional support for skin. Strategies that stimulate fibroblast activity and ECM synthesis are key in regenerative and aesthetic medicine. The aim of the study was to compare the effects of a hyaluronic acid plus six-amino acid formulation (HA6AA) with a polynucleotide mixture (PN) on extracellular matrix (ECM)-related gene… Read on PubMed →
Clay-polysaccharides as engineered nanoplatforms for cancer treatment.
Carbohydrate polymers · 2026
This review highlights recent advances in designing bionanocomposites that combine clay minerals with polysaccharides as multifunctional platforms for cancer therapy. Polysaccharides such as chitosan, hyaluronic acid, alginate, pectin and cellulose derivatives offer biocompatibility, biodegradability and versatile chemical functionality, while clays including montmorillonite, sepiolite, halloysite… Read on PubMed →
Aesthetic Concerns and Nonsurgical Treatment Trends in Patients With GLP-1 Agonist-Associated Weight Loss.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2026
BACKGROUND: Weight loss associated with glucagon-like peptide-1 (GLP-1) agonists is frequently accompanied by reduced facial fat, sagging skin, and stubborn pockets of body fat. OBJECTIVE: To identify aesthetic concerns related to GLP-1 agonist-associated weight loss and current nonsurgical treatment trends. MATERIALS AND METHODS: An electronic survey was sent to health care professionals (HCPs)… Read on PubMed →
GLP-1-Induced Weight Loss and the Face: Anatomical Mechanisms and Rationale for Collagen-Stimulating and Volumizing Aesthetic Treatments.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2026
BACKGROUND: Glucagon-like peptide-1 (GLP-1) receptor agonists have transformed medical weight-loss therapy and have been associated with characteristic facial changes, including hollowing, skin laxity, and contour alterations that may accentuate pre-existing signs of aging. OBJECTIVE: To review the anatomical basis of facial changes after GLP-1-associated weight loss and provide an evidence-based… Read on PubMed →
Emerging Patterns in Dietary Supplement Use Among US Adults, 1999-2023.
JAMA network open · 2026
IMPORTANCE: Dietary supplement use is widespread among US adults, but long-term national data, particularly on emerging products and COVID-19-related changes, are limited. Understanding population-level changes is essential to inform research and public health priorities. OBJECTIVE: To evaluate 25-year trends in dietary supplement use among US adults. DESIGN, SETTING, AND PARTICIPANTS: This… Read on PubMed →
A co-amorphous salt of ursodeoxycholic acid and matrine incorporated into dissolving microneedles for combined antibacterial and anti-inflammatory treatment of acne vulgaris.
International journal of pharmaceutics · 2026
Acne vulgaris is characterized by microbial dysbiosis and excessive inflammatory activation, whereas current topical therapies are often limited by poor skin penetration and increasing antibiotic resistance. Ursodeoxycholic acid (UDCA) has anti-inflammatory potential but suffers from low aqueous solubility and limited cutaneous permeability. In this study, a co-amorphous salt of UDCA and matrine… Read on PubMed →
Polysaccharide-Based Soluble Microneedle Transdermal Delivery of Curcumin Synergized with Photothermal Therapy for Acne Treatment.
ACS applied materials & interfaces · 2026
Acne is a chronic inflammatory skin disease driven primarily by Propionibacterium acnes (P. acnes) colonization in hair follicles, which can progress from mild to severe forms and result in permanent scarring if left untreated. To resolve this problem, this study developed a polysaccharide-based light-heat-mediated soluble microneedle system for the transdermal delivery of antiacne agents… Read on PubMed →
Tear Trough Deformity: Update on Anatomy and Clinical Management.
Aesthetic surgery journal · 2026
Tear trough deformity represents a distinct and defining feature of lower eyelid aging and rejuvenation and is a frequent contributor to a fatigued or aged appearance. Management strategies vary widely, reflecting differences in patient anatomy, deformity severity, and surgical philosophy. This review updates contemporary anatomic concepts of the tear trough and integrates these findings with… Read on PubMed →
Efficacy of Japanese Maca Powder Against Aging Stress in Human Dermal Fibroblasts.
International journal of molecular sciences · 2026
The aim of this study was to identify and examine materials that have a long history of use in folk medicine and exhibit biological activity but have not been fully utilized. This study evaluated the reactivity of Japanese maca powder in cultured human dermal cells subjected to aging stress (UV irradiation, AGE treatment, or H2O2 treatment). The mRNA levels of three stress parameters (collagen… Read on PubMed →