Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
Showing research linked to Vitamin A (view profile)
Clear12 papers
Epalrestat repurposing for psoriasis: Targeting AKR1B10 to modulate the metabolic-immune axis via restoring retinol metabolism and suppressing IL-17 signaling.
International immunopharmacology · 2026
BACKGROUND: Psoriasis is a chronic inflammatory disease often accompanied by metabolic syndrome. The function of AKR1B10 in the "metabolism-immune" interplay remains unclear. This study aimed to identify the role of AKR1B10 in pathogenesis and evaluate its inhibitor, Epalrestat, for psoriasis treatment via drug repurposing. METHODS: Integrating GEO transcriptomic data, we screened for key… Read on PubMed →
A skin-hypothalamus axis couples heat stress and metabolic dysfunction.
Cell · 2026
With the ongoing rise in global temperatures, the prevalence of heat-stress-related chronic health disorders has increased. However, whether heat stress has an enduring impact on metabolic health remains unclear. Here, we report that mice exposed to heat stress were more susceptible to metabolic dysfunction upon subsequent exposure to an obesogenic diet. Upon heat stress, we found that elevated… Read on PubMed →
A Novel Retinoid and Salicylic Acid Topical Treatment for Moderate-Severe Acne.
Journal of drugs in dermatology : JDD · 2026
BACKGROUND: Advances in biotechnology have enabled highly effective, site-specific topical therapies for skin disease. Particle-based delivery systems can be engineered with tailored physicochemical properties and surface modifications to optimize controlled drug release and skin targeting, potentially improving acne treatment outcomes. OBJECTIVE: To evaluate the effectiveness and tolerability of… Read on PubMed →
Vitamin A: Biological Functions and Implications for Muscle Health.
Nutrition reviews · 2026
Skeletal muscle diseases represent a diverse group of conditions, often characterized by muscle weakness, atrophy, and functional impairment. These disorders continue to impose a significant burden on global health, affecting millions of individuals worldwide. As the prevalence of muscle-related diseases rises, it becomes increasingly important to understand the complex biological mechanisms that… Read on PubMed →
Tower-shaped super-adhesive microneedles loaded with vitamin A-containing Bletilla striata vesicles: temporally regulated Inflammation resolution and ECM remodeling for scarless wound healing.
Journal of nanobiotechnology · 2026
Pathological scars, resulting from abnormal collagen metabolism during wound healing, pose clinical challenges due to the high recurrence rates of conventional treatments. Therefore, early-stage modulation of the wound healing process is emerging as a pivotal strategy for preventing and treating pathological scars, necessitating precise coordination of vascular regeneration, inflammation… Read on PubMed →
Retinoic acid at the crossroads of reproduction and sleep: an underexplored link with clinical implications.
Reproduction (Cambridge, England) · 2026
Retinoic acid, a vitamin A derivative widely used in dermatology, plays essential roles in female and male reproductive physiology and in the regulation of circadian rhythms. Emerging evidence suggests that chronic exposure to systemic retinoids, such as isotretinoin, may influence fertility parameters and sleep-reproductive interactions, highlighting the need for greater clinical awareness and… Read on PubMed →
Antioxidant regulatory mechanisms of retinoic acid and its therapeutic potential in oxidative stress-related diseases.
Biochemical pharmacology · 2026
As a metabolite of vitamin A, retinoic acid (RA) is bound to nuclear receptors (RAR/RXR) to produce effects and regulate gene expression, showing antioxidant, anti-inflammatory, and anti-apoptotic activities [1]. Oxidative stress, induced by both endogenous and exogenous factors, results in the excessive accumulation of reactive oxygen species (ROS) in specific areas, which can damage cellular… Read on PubMed →
Topical vitamins: Uses and limitations-part I.
Clinics in dermatology · 2026
Topical formulations of vitamins are increasingly used for dermatologic conditions and cosmetic indications, owing to their anti-inflammatory and antioxidant effects, modulation of cell proliferation and differentiation, wound-healing effects, and moisturizing and photoprotective properties. Apart from well-established uses in psoriasis and acne vulgaris, they are helpful for various new… Read on PubMed →
Hypervitaminosis: The deleterious effects of vitamins on the skin.
Clinics in dermatology · 2026
Vitamin supplementation has recently shown a dramatic increase in usage, especially during the COVID-19 pandemic, as a potential aid in preventing, treating, and recovering from infection. In dermatology, vitamin supplements may be used to support the management of a myriad of conditions. A common misconception is that vitamins are safe to consume and that taking more will improve overall health… Read on PubMed →
Vitamins and skin aging.
Clinics in dermatology · 2026
This comprehensive analysis sheds light on the crucial roles played by vitamins in anti-aging strategies across three key domains: topical care, cosmetic procedures, and systemic therapy. Vitamins significantly influence skin health, contributing to hydration, collagen synthesis, and protection against oxidative damage. In topical care, vitamins are harnessed in various formulations such as… Read on PubMed →
Design and evaluation of multi-target AGEs/ALEs inhibitors for potential application in skin anti-aging.
Future medicinal chemistry · 2026
The main causes of skin aging include both intrinsic and extrinsic factors such as oxidative stress triggered by reactive oxygen species (ROS), modification of collagen and elastin by reactive carbonyl species (RCS), UV exposure, lifestyle habits and environmental pollutants. Skin aging is the most visible manifestation of senescence and is unavoidable. In particular, delaying age-related changes… Read on PubMed →
Retinol-Loaded Mannosylerythritol Lipid Nanoliposome for Enhanced Human Skin Penetration.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026
BACKGROUND: Functional cosmetic materials with anti-aging properties, such as wrinkle reduction, often struggle to penetrate the skin's stratum corneum (skin barrier). Therefore, to exert anti-aging effects, these materials must pass through the skin barrier and reach fibroblasts in the dermal layer. In this study, deformable liposomes were developed for efficient transdermal delivery of retinol… Read on PubMed →