Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
Showing research linked to Methotrexate (view profile)
Clear5 papers
Epalrestat repurposing for psoriasis: Targeting AKR1B10 to modulate the metabolic-immune axis via restoring retinol metabolism and suppressing IL-17 signaling.
International immunopharmacology · 2026
BACKGROUND: Psoriasis is a chronic inflammatory disease often accompanied by metabolic syndrome. The function of AKR1B10 in the "metabolism-immune" interplay remains unclear. This study aimed to identify the role of AKR1B10 in pathogenesis and evaluate its inhibitor, Epalrestat, for psoriasis treatment via drug repurposing. METHODS: Integrating GEO transcriptomic data, we screened for key… Read on PubMed →
Structure-Based Virtual Screening and Mechanistic Characterization of Methotrexate and Selinexor as Potent Anti-Melanogenic Agents via Multi-Pathway Suppression of MITF.
Cells · 2026
Tyrosinase is a pivotal therapeutic target for hyperpigmentation disorders, yet current inhibitors frequently exhibit limited potency and suboptimal safety. Here, we employed structure-based virtual screening of an FDA-approved drug library against a refined human tyrosinase homology model, identifying methotrexate and selinexor as potent anti-melanogenic candidates. Both compounds markedly… Read on PubMed →
Clinical Characteristics and Treatment Patterns of Psoriasis in Asia and Switzerland: Results of the Multicentre Global Healthcare Study on Psoriasis (GHSP).
International journal of dermatology · 2026
BACKGROUND: Psoriasis is a chronic inflammatory skin and systemic disease with a wide range of clinical manifestations and treatment options, including topicals, phototherapy, non-biologic systemic treatments, and biologics. Understanding regional differences in clinical characteristics and treatment patterns can help improve equity and access to care globally. METHODS: The Global Healthcare… Read on PubMed →
Update on cutaneous lupus erythematosus pathogenesis, diagnosis and management.
Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
Cutaneous lupus erythematosus (CLE) encompasses a spectrum of skin manifestations that may occur as an isolated dermatological condition or in association with systemic lupus erythematosus (SLE). This review provides an updated synthesis of current knowledge on CLE, including its classification, pathogenesis, clinical presentation and diagnostic strategy. It will discuss recent advances in… Read on PubMed →
Population-Specific HLA Profiles in Generalised Pustular Psoriasis in Sarawak, Malaysia.
Experimental dermatology · 2026
Genetic studies mutations (IL36RN, CARD14 and AP1S3) account for only 28.6% of generalised pustular psoriasis (GPP) leaving much of its pathogenesis remained to be elucidated. Emerging evidence suggests Th17-mediated inflammation, potentially driven by specific HLA class alleles, may underlie dysregulated IL-36 signalling. This study explores the genotypic and phenotypic features of autochthonous… Read on PubMed →