Research
Latest published research we're tracking.
The newest skincare and haircare papers from PubMed, linked to the ingredients we decode. Summaries are the authors' own abstracts — we excerpt, attribute, and link out to the source.
Showing research linked to Vitamin C (view profile)
Clear19 papers
Dual-mechanism vitamin C delivery by polyethylene glycol-23 glyceryl distearate-based niosomes via SVCT2 induction and enhanced transdermal penetration.
Drug delivery · 2026
Polyethylene glycol-23 glyceryl distearate (GDS-23)-a noisome-forming diacylglycerol-polyethylene glycol-based nonionic surfactant-functions as a nanocarrier for drug delivery systems (DDS) and an enhancer of endogenous antioxidant capacity through nuclear factor erythroid 2-related factor 2 (Nrf2) activation. Here, we evaluated the potential of GDS-23 as a multifunctional DDS carrier by… Read on PubMed →
Skin Cells' Protection Against UVA-Induced Changes in Co-Cultured Keratinocytes-Fibroblasts' Proteome and Released Signaling Proteins by 3-O-Ethyl Ascorbic Acid.
International journal of molecular sciences · 2026
UVA radiation affects communication between the cells that create the human skin. To prevent UVA-induced damage, there is a constant search for compounds protecting all skin cells and homeostasis in their communication. Therefore, the aim of this study was to evaluate the effect of 24 h incubation with 3-O-ethyl ascorbic acid (EAA; 150 µM) on the intracellular proteome of co-cultured keratinocytes… Read on PubMed →
Neoagarotetraose from Marine Red Algae Ameliorates UVB-Induced Skin Barrier Damage in Mice and HaCaT Keratinocytes.
Marine biotechnology (New York, N.Y.) · 2026
Ultraviolet B (UVB) radiation is a major environmental threat that disrupts skin integrity and drives inflammatory skin disorders. Neoagarotetraose (NA4), a low-molecular-weight oligosaccharide derived from marine red algae, is characterized by high bioavailability and well-documented anti-inflammatory properties, yet its role in UVB-induced skin damage remains unexplored. In this study, we… Read on PubMed →
Wearable Colorimetric Biosensor Based on Copper Coordination Polymer Nanozymes for Noninvasive Monitoring of Ascorbic Acid.
Langmuir : the ACS journal of surfaces and colloids · 2026
Real-time monitoring of ascorbic acid (AA) in sweat is critical for evaluating oxidative stress and nutritional status. However, the practical application of current wearable sensors is often compromised by complex matrix interference and interfacial instability during physical activity. To address these challenges, we developed a high-performance wearable colorimetric sensing platform based on… Read on PubMed →
Topical Ascorbic Acid for Corneal Endothelial Cell Density Enhancement, Protection, and Recovery in Fuchs Dystrophy After Complicated Cataract Surgery.
Eye & contact lens · 2026
We report a case highlighting the potential of topical ascorbic acid (AA) as an adjunctive strategy for supporting corneal endothelial stability in Fuchs endothelial corneal dystrophy (FECD) after complicated cataract surgery. A 74-year-old man with bilateral FECD presented with progressive vision loss. Baseline endothelial cell density (ECD) was 1,996 cells/mm2 in the right eye and 1,988… Read on PubMed →
In Vitro Assessment of Stimulation of Collagen Biosynthesis via Collagenprash and Collagen Builder.
Journal of agricultural and food chemistry · 2026
The skin serves as the primary physical barrier and plays a critical role in the aesthetic appearance, particularly through its pigmentation and texture. Collagenprash and Collagen builder are developed to support skin integrity by promoting collagen-associated protein expression. This study systematically evaluated these claims through a variety of biochemical and cellular assays. The… Read on PubMed →
Proteomic Analysis of the Metabolic Response of UVA-Exposed Melanocytes Following Co-Treatment with Cannabigerol and 3-O-Ethylascorbic Acid.
Cells · 2026
The aim of this study was to analyze the effect of concomitant use of cannabigerol (CBG) and 3-O-ethylascorbic acid (EAA) on changes in the proteome of UVA-irradiated skin melanocytes, with particular emphasis on adduct formation between lipid peroxidation products and metabolically important proteins. Proteomic analysis allowed the identification of 1248 proteins with statistically significantly… Read on PubMed →
A flexible multichannel wearable sensor for real-time monitoring of exercise-induced sweat composition.
Talanta · 2026
To address low sensitivity, severe environmental interference, single-analyte detection, and traditional rigid substrates' inability to adapt to dynamic skin deformation in surface metabolite detection, polyethylene terephthalate (PET) was selected as the flexible substrate. A multi-channel flexible wearable biosensor with mechanical adaptability and multi-parameter detection capability was… Read on PubMed →
Topical Vitamin C in the Prevention and Treatment of Actinic Keratoses and Nonmelanoma Skin Cancers: A Systematic Scoping Review.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2026
BACKGROUND: Vitamin C is an antioxidant that is involved in collagen synthesis, maintenance of the skin barrier, and neutralization of free oxygen radicals in the skin. The potential for use of topical vitamin C as a therapeutic and protective agent against actinic keratoses (AKs) and skin cancers has not been fully delineated. OBJECTIVE: To review the current evidence on topical vitamin C in the… Read on PubMed →
Comparison of Selected Pro-Health Biologically Active Chemical Compounds in Salviae herba from Selected Species.
Molecules (Basel, Switzerland) · 2026
Pharmaceutical, cosmetic, and food industries have contributed to the increasing interest in herbal phytochemicals. Salvia, a multifunctional culinary herb, meets phytotherapeutic requirements in the treatment of heartburn, excessive sweating, flatulence, and mouth, throat, and skin inflammatory conditions. Salviae folium is used in conductive education, i.e., a unique rehabilitation method for… Read on PubMed →
Novel Combination Of Antioxidants To Restore Healthy Intercellular Communication In An In vitro Model Using Conditioned Medium From Senescent Cells.
Journal of visualized experiments : JoVE · 2026
Skin aging is a multifactorial process driven by alterations at the molecular and cellular level, also known as hallmarks of aging. One of these alterations consists of altered intercellular communication, which contributes to skin tissue dysfunction and structural damage. Here, an in vitro model to mimic these skin aging features by incubating healthy fibroblasts with conditioned medium from… Read on PubMed →
The heterogeneity of dermal mesenchymal cells reproduced in skin equivalents regulates barrier function and elasticity.
EMBO reports · 2026
The heterogeneity of dermal mesenchymal cells, including perivascular mesenchymal cells and papillary and reticular fibroblasts, plays critical roles in skin homeostasis. Herein, we present human skin equivalents (HSEs), in which pericytes, papillary fibroblasts, and reticular fibroblasts are spatially organized through autonomous three-cell interactions among epidermal keratinocytes, dermal… Read on PubMed →
Skin cancer and vitamins: In theory and practice.
Clinics in dermatology · 2026
Skin cancers are common malignant tumors with an increasing incidence worldwide. The major types are cutaneous malignant melanoma and keratinocytic tumors, such as basal cell carcinoma and cutaneous squamous cell carcinoma. The first treatment of choice is complete surgical removal, but nonsurgical treatment options and primary prevention may be requested. Vitamins may play a role in skin cancer… Read on PubMed →
Study on the Multiple Efficacies of Vitamin C Serum in Anti-Glycation, Anti-Carbonylation, Antioxidation, and Anti-Inflammation of Human Skin Based on In Vivo Tests.
Journal of cosmetic dermatology · 2026
BACKGROUND: Skin glycation, oxidation, carbonylation, and excessive inflammation are well-recognized factors contributing to skin aging and pigmentation. Previous in vitro studies have confirmed vitamin C's antioxidant, anti-glycation, and anti-inflammatory properties, but its in vivo effects remain to be further verified. AIMS: To investigate the in vivo effects of topical vitamin C serum on… Read on PubMed →
A Narrative Review of Candidate Biomarkers of Total Fruit and Vegetable Intake.
Nutrition bulletin · 2026
While an abundance of cohort studies has suggested that greater consumption of fruits and vegetables (FVs) is associated with reduced risk of chronic diseases, current self-report based dietary assessment tools are susceptible to biases that can reduce their accuracy in estimating dietary intakes, and consequently, the risk estimates obtained from this research. As a result, considerable attention… Read on PubMed →
Establishing synergistic role of acacia honey and vitamin C: A promising strategy for faster wound tissue regeneration.
Injury · 2026
Being established as an important natural component for wound healing, acacia honey (AH) in combination with ascorbic acid (AA) was evaluated for its tissue regenerative properties to establish a synergistic effect. A thermosensitive hydrogel formulation was developed and characterized for viscosity, mucoadhesion, moisture retention, pH, and morphology, where the parameters were found to be… Read on PubMed →
Topical vitamins: Uses and limitations-part I.
Clinics in dermatology · 2026
Topical formulations of vitamins are increasingly used for dermatologic conditions and cosmetic indications, owing to their anti-inflammatory and antioxidant effects, modulation of cell proliferation and differentiation, wound-healing effects, and moisturizing and photoprotective properties. Apart from well-established uses in psoriasis and acne vulgaris, they are helpful for various new… Read on PubMed →
Vitamins and skin aging.
Clinics in dermatology · 2026
This comprehensive analysis sheds light on the crucial roles played by vitamins in anti-aging strategies across three key domains: topical care, cosmetic procedures, and systemic therapy. Vitamins significantly influence skin health, contributing to hydration, collagen synthesis, and protection against oxidative damage. In topical care, vitamins are harnessed in various formulations such as… Read on PubMed →
Design and evaluation of multi-target AGEs/ALEs inhibitors for potential application in skin anti-aging.
Future medicinal chemistry · 2026
The main causes of skin aging include both intrinsic and extrinsic factors such as oxidative stress triggered by reactive oxygen species (ROS), modification of collagen and elastin by reactive carbonyl species (RCS), UV exposure, lifestyle habits and environmental pollutants. Skin aging is the most visible manifestation of senescence and is unavoidable. In particular, delaying age-related changes… Read on PubMed →