benzoyl peroxidesalicylic acid
Cited benefitstrong evidence
Yes — a cited synergy.
A meta-analysis of 23 RCTs (7309 patients) found 5% benzoyl peroxide combined with a salicylic acid preparation out-performed benzoyl peroxide alone at every measured timepoint — at 2-4 weeks, inflammatory lesions fell 55.2% vs. 33.4% and noninflammatory lesions fell 42.7% vs. 19.1%; by 10-12 weeks the gap narrowed but BP+SA still edged out BP alone (51.8% vs. 43.7% inflammatory; 47.8% vs. 30.9% noninflammatory). The meta-analysis's senior author discloses general dermatology-industry consulting ties (not specific to a single BP or SA product); the first author declares no conflicts.