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Evidence for this pairing is limited.
Plausible dual pigment-pathway hit — azelaic acid inhibits tyrosinase while vitamin C is both a tyrosinase inhibitor and a topical antioxidant — but a comprehensive 2025 review of azelaic acid states plainly that combining it with antioxidants like vitamin C is compatible while cautioning that synergistic effects have yet to be fully substantiated by direct trial evidence.
This describes a general ingredient interaction backed by the cited research below, not a diagnosis or a personalized skincare plan. Individual skin varies — introduce new actives gradually and talk to a dermatologist about your own routine.