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Histopathological evaluation of facial melasma treated with oral tranexamic acid alone and in combination with ketotifen.

Anais brasileiros de dermatologia · 2026

BACKGROUND: Tranexamic Acid (TA) has demonstrated effectiveness on melasma treatment, and Ketotifen (KET) may inhibit mast cell-mediated melanogenesis. The histologic basis of their depigmenting effects remains unclear. OBJECTIVES: To evaluate histopathological changes from TA with KET over a 3-month treatment. METHODS: In this randomized, double-blind trial, 50 women with facial melasma were… Read on PubMed →