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Application of a next generation risk assessment framework, integrated testing strategy defined approaches and read-across for evaluating the skin sensitization potency: Case studies with 5-hydroxymethylfurfural and 5,5'-oxydimethylenebis (2-furfural).

Regulatory toxicology and pharmacology : RTP · 2026

Evaluating skin sensitization is crucial for the safety of cosmetics and pharmaceuticals. Regulatory bans on animal testing have spurred the development of New Approach Methodologies (NAMs), Integrated Testing Strategies (ITS), and Next Generation Risk Assessment (NGRA). Defined Approaches (DAs) that combine various NAMs have been developed to assess skin sensitization hazards and potency, as… Read on PubMed →