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Genistein
In cosmetic formulas, Genistein leaves skin feeling smoother or better cared for.
What does Genistein do in a formula?
Genistein leaves skin feeling smoother or better cared for.
The listed functions explain its role in a formula. They do not establish whether a finished product will suit your skin.
No reviewed benefit claim is available here yet. Compare the complete formula, its directions, and your own skin preferences.
What a CosIng listing meansBeauty reading & sources
Beauty articles & blogs (1)
Further reading from beauty writers and cosmetic formulators.
- What’s the deal with fermented skincare? | Lab Muffin Beauty Science
Lab Muffin Beauty Science
Beauty science blog; affiliate links and sponsorships may be present.
Research papers (28)
Related papers naming this ingredient in their title or in a beauty-relevant abstract passage. Laboratory, clinical and exposure studies have different scopes; these links are not reviewed benefit claims.
- Endocrine Disrupting Chemicals, Hormone Receptors, and Acne Vulgaris: A Connecting Hypothesis.
Cells · 2021
- Dietary Management of Skin Health: The Role of Genistein.
Nutrients · 2017
Oral or dietary context; not evidence for topical use.
- Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy.
International journal of nanomedicine · 2016
See 25 more research papers
- Polyphenols: skin photoprotection and inhibition of photocarcinogenesis.
Mini reviews in medicinal chemistry · 2011
- Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms.
Archives of dermatological research · 2010
- Effect of vehicle on the in vitro penetration and metabolism of genistein and daidzein in ex vivo skin explants and the Phenion full-thickness skin model.
Journal of applied toxicology : JAT · 2025
- Application of a skin and liver Chip2 microphysiological model to investigate the route-dependent toxicokinetics and toxicodynamics of consumer-relevant doses of genistein.
Journal of applied toxicology : JAT · 2024
- ROS Scavenging Effect of Selected Isoflavones in Provoked Oxidative Stress Conditions in Human Skin Fibroblasts and Keratinocytes.
Molecules (Basel, Switzerland) · 2024
- Sophoricoside, a genistein glycoside from Fructus Sophorae, promotes hair growth via activation of M4 muscarinic AChR in dermal papilla cells.
Journal of ethnopharmacology · 2024
- Efficacy and Safety of the Genistein Nutraceutical Product Containing Vitamin E, Vitamin B3, and Ceramide on Skin Health in Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Journal of clinical medicine · 2023
- Enhancement of the Topical Bioavailability and Skin Whitening Effect of Genistein by Using Microemulsions as Drug Delivery Carriers.
Pharmaceuticals (Basel, Switzerland) · 2021
- Development and In Vitro Evaluation of Vitamin E-Enriched Nanoemulsion Vehicles Loaded with Genistein for Chemoprevention Against UVB-Induced Skin Damage.
Journal of pharmaceutical sciences · 2015
- Genistein prevents ultraviolet B radiation-induced nitrosative skin injury and promotes cell proliferation.
Journal of photochemistry and photobiology. B, Biology · 2015
- Influence of genistein on c-Jun, c-Fos and Fos-B of AP-1 subunits expression in skin keratinocytes, fibroblasts and keloid fibroblasts cultured in vitro.
Acta poloniae pharmaceutica · 2013
- Genistein aglycone, a soy-derived isoflavone, improves skin changes induced by ovariectomy in rats.
British journal of pharmacology · 2012
- Validation of an LC method to determine skin retention profile of genistein from nanoemulsions incorporated in hydrogels.
Journal of chromatographic science · 2012
- Synergic Effect of Genistein and Daidzein on UVB-Induced DNA Damage: An Effective Photoprotective Combination.
Journal of biomedicine & biotechnology · 2011
- Genistein aglycone improves skin repair in an incisional model of wound healing: a comparison with raloxifene and oestradiol in ovariectomized rats.
British journal of pharmacology · 2010
- In vitro and in vivo evaluation of topical delivery and potential dermal use of soy isoflavones genistein and daidzein.
International journal of pharmaceutics · 2008
- Topical isoflavones provide effective photoprotection to skin.
Photodermatology, photoimmunology & photomedicine · 2008
- Photoprotective effect of isoflavone genistein on ultraviolet B-induced pyrimidine dimer formation and PCNA expression in human reconstituted skin and its implications in dermatology and prevention of cutaneous carcinogenesis.
Carcinogenesis · 2006
- Contrasting action of flavonoids on phototoxic effects induced in human skin fibroblasts by UVA alone or UVA plus cyamemazine, a phototoxic neuroleptic.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2005
- Topical application of Bifidobacterium-fermented soy milk extract containing genistein and daidzein improves rheological and physiological properties of skin.
Journal of cosmetic science · 2004
- Dietary soy oil content and soy-derived phytoestrogen genistein increase resistance to alopecia areata onset in C3H/HeJ mice.
Experimental dermatology · 2003
Oral or dietary context; not evidence for topical use.
- Isoflavone genistein: photoprotection and clinical implications in dermatology.
The Journal of nutrition · 2003
- Topical N-acetyl cysteine and genistein prevent ultraviolet-light-induced signaling that leads to photoaging in human skin in vivo.
The Journal of investigative dermatology · 2003
- American Academy of Dermatology 1998 Awards for Young Investigators in Dermatology. Photoprotective action of isoflavone genistein: models, mechanisms, and relevance to clinical dermatology.
Journal of the American Academy of Dermatology · 1998
- Interleukin-1beta-induced inhibition of hair growth in vitro is mediated by cyclic AMP.
The Journal of investigative dermatology · 1997
PubMed is hosted by the U.S. National Library of Medicine. Listing there does not mean NIH authored or endorses a paper.
Cosmetic ingredient references
- Genistein in COSMILE Europe
Industry ingredient directory · matched to the publisher’s ingredient index.
- Genistein in INKEEDecoder
Commercial ingredient explainer directory, formerly INCIDecoder · matched to its publisher index; claims not independently reviewed.
- European Commission CosIng database
Catalog reference 85188. Database inclusion is not approval or proof of safety or effectiveness.
Which papers mention Genistein?
The research feed contains 1 linked papers (2026).
Highlights below name the ingredient or a recorded alias in their titles. A mention does not establish a skincare benefit: a paper may study oral use, a combination formula, or a different population. Reviewed ingredient claims, when available, are assessed separately for their stated scope.
- A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GEN<sup>+</sup>) Product for Male Facial Skin: Effects on Skin Appearance and Properties.
Title mentions Genistein.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2026
Where it fits in real formulas
Related ingredients, common formula neighbors, naming, and catalog context. This stays separate from evidence and personal-fit guidance.
Similar ingredients
related by documented function or concern
Hyaluronic Acid (salt form)Pulls water into the skin for immediate hydration and a plumper lookPro-vitamin B5Moisturizes and improves hydration by drawing and holding water in the skinAllantoinHelps condition and soften the skin surfaceCeramide NpHelps replenish surface lipids within an appropriately formulated moisturizerCicaFunctions as a botanical skin-conditioning ingredientHyaluronic AcidBinds water at the skin surface and supports short-term hydration. The widely repeated claim that it holds 1,000 times its weight in water is not supported by direct measurement. A 2025 review reported about 0.7–2 grams of water per gram of polysaccharide.
What kinds of products contain Genistein?
Real brands and product categories from the 3 decoded products listing Genistein — an observation of our catalog, not a claim about market share.
3 of 7,133 decoded products list this ingredient. Count calculated on (UTC). Counts describe our recorded labels, which may differ from current packaging; the public product list can be smaller than the decoded catalog.
How we collect ingredient listsBrands
Product categories
toners (2), serums (1)
Based on those categories, Genistein shows up mostly in leave-on products (3 of 3 classified) — derived from product category, not a label fact.
Commonly appears alongside
How often another ingredient appears in the same decoded products. This does not show routine compatibility.
Which products contain Genistein?
All 3 →3 public products list this ingredient.
Catalog preview
A compact look at the first products in this result set
1–1 / 3
About the sources
Ingredient lists show presence and order, not concentration, pH, ingredient grade, delivery system, or finished-formula performance.
Sources & methodologyCompiled from the EU CosIng database (ref 85188) · snapshot 16 June 2026. CosIng is an informational, non-legally-binding reference. Inclusion does not mean an ingredient is approved, safe, authorized for cosmetic use, or clinically effective. An INCI list does not reveal concentration, pH, ingredient grade, delivery system, or finished-formula performance.