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Unexplained bleeding tendency and scleroderma-like skin changes: a diagnostic journey to vitamin C deficiency.

Research and practice in thrombosis and haemostasis · 2026

BACKGROUND: A subset of patients with a bleeding tendency undergoing hemostatic evaluation may be misdiagnosed as bleeding disorder of unknown cause (BDUC). KEY CLINICAL QUESTION: Should vitamin C deficiency be considered in patients with bleeding symptoms but normal hemostatic test results suggestive of BDUC? CLINICAL APPROACH: We report on a patient with bleeding symptoms despite normal… Read on PubMed →