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The hyaluronan receptor CD44 drives COVID-19 severity through its regulation of neutrophil migration.

PLoS pathogens · 2026

The novel respiratory disease COVID-19 caused by the coronavirus SARS-CoV-2 continues to be a public health emergency worldwide, and there is a need for more effective therapy for patients. The relationship between the extracellular matrix and the host immune response to infection is severely understudied. Deposition of the polysaccharide hyaluronan (HA) into the lungs is associated with more… Read on PubMed →